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Gene: ANKRD36B |
Gene summary for ANKRD36B |
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Gene information | Species | Human | Gene symbol | ANKRD36B | Gene ID | 57730 |
Gene name | ankyrin repeat domain 36B | |
Gene Alias | KIAA1641 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8N2N9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57730 | ANKRD36B | LZE8T | Human | Esophagus | ESCC | 7.12e-06 | 2.80e-01 | 0.067 |
57730 | ANKRD36B | LZE21D1 | Human | Esophagus | HGIN | 4.37e-04 | 3.68e-01 | 0.0632 |
57730 | ANKRD36B | LZE22D1 | Human | Esophagus | HGIN | 8.48e-06 | 2.47e-01 | 0.0595 |
57730 | ANKRD36B | LZE22T | Human | Esophagus | ESCC | 3.19e-02 | 3.09e-01 | 0.068 |
57730 | ANKRD36B | LZE24T | Human | Esophagus | ESCC | 1.67e-18 | 2.39e-01 | 0.0596 |
57730 | ANKRD36B | LZE21T | Human | Esophagus | ESCC | 1.35e-04 | 4.02e-01 | 0.0655 |
57730 | ANKRD36B | LZE6T | Human | Esophagus | ESCC | 9.72e-06 | 1.46e-01 | 0.0845 |
57730 | ANKRD36B | P1T-E | Human | Esophagus | ESCC | 2.92e-06 | 3.55e-01 | 0.0875 |
57730 | ANKRD36B | P2T-E | Human | Esophagus | ESCC | 7.98e-13 | 1.83e-01 | 0.1177 |
57730 | ANKRD36B | P4T-E | Human | Esophagus | ESCC | 1.28e-22 | 4.44e-01 | 0.1323 |
57730 | ANKRD36B | P5T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.58e-01 | 0.1327 |
57730 | ANKRD36B | P8T-E | Human | Esophagus | ESCC | 1.35e-07 | 9.10e-02 | 0.0889 |
57730 | ANKRD36B | P9T-E | Human | Esophagus | ESCC | 4.09e-07 | 1.09e-01 | 0.1131 |
57730 | ANKRD36B | P10T-E | Human | Esophagus | ESCC | 1.01e-31 | 5.19e-01 | 0.116 |
57730 | ANKRD36B | P11T-E | Human | Esophagus | ESCC | 2.35e-06 | 1.36e-01 | 0.1426 |
57730 | ANKRD36B | P12T-E | Human | Esophagus | ESCC | 2.60e-10 | 2.45e-01 | 0.1122 |
57730 | ANKRD36B | P15T-E | Human | Esophagus | ESCC | 7.67e-18 | 2.37e-01 | 0.1149 |
57730 | ANKRD36B | P16T-E | Human | Esophagus | ESCC | 6.37e-17 | 2.75e-01 | 0.1153 |
57730 | ANKRD36B | P20T-E | Human | Esophagus | ESCC | 4.38e-10 | 2.06e-01 | 0.1124 |
57730 | ANKRD36B | P21T-E | Human | Esophagus | ESCC | 1.13e-16 | 2.64e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD36B | SNV | Missense_Mutation | novel | c.1319A>G | p.Lys440Arg | p.K440R | Q8N2N9 | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-A2-A0EP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
ANKRD36B | SNV | Missense_Mutation | novel | c.843N>C | p.Lys281Asn | p.K281N | Q8N2N9 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ANKRD36B | SNV | Missense_Mutation | novel | c.550N>T | p.Leu184Phe | p.L184F | Q8N2N9 | protein_coding | tolerated(0.15) | benign(0.205) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ANKRD36B | SNV | Missense_Mutation | novel | c.788N>G | p.Glu263Gly | p.E263G | Q8N2N9 | protein_coding | tolerated(0.51) | benign(0) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
ANKRD36B | insertion | In_Frame_Ins | novel | c.786_787insTTG | p.Ala262_Glu263insLeu | p.A262_E263insL | Q8N2N9 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
ANKRD36B | insertion | Frame_Shift_Ins | novel | c.1997_1998insTA | p.Gln666HisfsTer18 | p.Q666Hfs*18 | Q8N2N9 | protein_coding | TCGA-BH-A0HN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
ANKRD36B | insertion | In_Frame_Ins | novel | c.1995_1996insTTC | p.Pro665_Gln666insPhe | p.P665_Q666insF | Q8N2N9 | protein_coding | TCGA-BH-A0HN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
ANKRD36B | SNV | Missense_Mutation | novel | c.1906G>A | p.Ala636Thr | p.A636T | Q8N2N9 | protein_coding | tolerated(0.23) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ANKRD36B | SNV | Missense_Mutation | novel | c.2216N>T | p.Ser739Leu | p.S739L | Q8N2N9 | protein_coding | deleterious(0) | benign(0.031) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD36B | SNV | Missense_Mutation | novel | c.97N>G | p.Leu33Val | p.L33V | Q8N2N9 | protein_coding | tolerated(1) | benign(0.007) | TCGA-VS-A8EC-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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