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Gene: AMN |
Gene summary for AMN |
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Gene information | Species | Human | Gene symbol | AMN | Gene ID | 81693 |
Gene name | amnion associated transmembrane protein | |
Gene Alias | IGS2 | |
Cytomap | 14q32.32 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9BXJ7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81693 | AMN | LZE24T | Human | Esophagus | ESCC | 5.01e-24 | 5.47e-01 | 0.0596 |
81693 | AMN | P1T-E | Human | Esophagus | ESCC | 7.43e-09 | 4.96e-01 | 0.0875 |
81693 | AMN | P2T-E | Human | Esophagus | ESCC | 4.78e-07 | 1.29e-01 | 0.1177 |
81693 | AMN | P4T-E | Human | Esophagus | ESCC | 1.26e-16 | 3.79e-01 | 0.1323 |
81693 | AMN | P5T-E | Human | Esophagus | ESCC | 6.22e-07 | 2.45e-01 | 0.1327 |
81693 | AMN | P8T-E | Human | Esophagus | ESCC | 5.44e-06 | 1.80e-01 | 0.0889 |
81693 | AMN | P9T-E | Human | Esophagus | ESCC | 9.50e-13 | 2.58e-01 | 0.1131 |
81693 | AMN | P10T-E | Human | Esophagus | ESCC | 9.45e-05 | 1.64e-01 | 0.116 |
81693 | AMN | P12T-E | Human | Esophagus | ESCC | 2.56e-14 | 2.97e-01 | 0.1122 |
81693 | AMN | P15T-E | Human | Esophagus | ESCC | 1.83e-09 | 2.28e-01 | 0.1149 |
81693 | AMN | P16T-E | Human | Esophagus | ESCC | 7.17e-05 | 9.45e-02 | 0.1153 |
81693 | AMN | P17T-E | Human | Esophagus | ESCC | 8.50e-05 | 2.40e-01 | 0.1278 |
81693 | AMN | P20T-E | Human | Esophagus | ESCC | 6.15e-13 | 2.94e-01 | 0.1124 |
81693 | AMN | P21T-E | Human | Esophagus | ESCC | 4.77e-13 | 2.38e-01 | 0.1617 |
81693 | AMN | P23T-E | Human | Esophagus | ESCC | 6.97e-41 | 9.57e-01 | 0.108 |
81693 | AMN | P26T-E | Human | Esophagus | ESCC | 7.12e-11 | 2.34e-01 | 0.1276 |
81693 | AMN | P27T-E | Human | Esophagus | ESCC | 1.24e-14 | 3.14e-01 | 0.1055 |
81693 | AMN | P28T-E | Human | Esophagus | ESCC | 3.69e-69 | 1.23e+00 | 0.1149 |
81693 | AMN | P30T-E | Human | Esophagus | ESCC | 3.47e-36 | 9.39e-01 | 0.137 |
81693 | AMN | P31T-E | Human | Esophagus | ESCC | 4.00e-22 | 5.09e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:0061951 | Colorectum | AD | establishment of protein localization to plasma membrane | 31/3918 | 60/18723 | 1.37e-07 | 6.42e-06 | 31 |
GO:0006892 | Colorectum | AD | post-Golgi vesicle-mediated transport | 45/3918 | 104/18723 | 2.22e-07 | 9.26e-06 | 45 |
GO:0043001 | Colorectum | AD | Golgi to plasma membrane protein transport | 21/3918 | 40/18723 | 1.03e-05 | 2.40e-04 | 21 |
GO:0006893 | Colorectum | AD | Golgi to plasma membrane transport | 27/3918 | 60/18723 | 2.41e-05 | 4.66e-04 | 27 |
GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
GO:00726591 | Colorectum | SER | protein localization to plasma membrane | 92/2897 | 284/18723 | 6.36e-13 | 1.86e-10 | 92 |
GO:19907781 | Colorectum | SER | protein localization to cell periphery | 98/2897 | 333/18723 | 6.09e-11 | 9.57e-09 | 98 |
GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
GO:00901501 | Colorectum | SER | establishment of protein localization to membrane | 68/2897 | 260/18723 | 5.55e-06 | 2.01e-04 | 68 |
GO:00068921 | Colorectum | SER | post-Golgi vesicle-mediated transport | 31/2897 | 104/18723 | 1.59e-04 | 3.08e-03 | 31 |
GO:00988761 | Colorectum | SER | vesicle-mediated transport to the plasma membrane | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
GO:00619511 | Colorectum | SER | establishment of protein localization to plasma membrane | 20/2897 | 60/18723 | 4.60e-04 | 6.65e-03 | 20 |
GO:00430011 | Colorectum | SER | Golgi to plasma membrane protein transport | 14/2897 | 40/18723 | 1.88e-03 | 1.90e-02 | 14 |
GO:00726592 | Colorectum | MSS | protein localization to plasma membrane | 113/3467 | 284/18723 | 3.23e-17 | 1.55e-14 | 113 |
GO:19907782 | Colorectum | MSS | protein localization to cell periphery | 120/3467 | 333/18723 | 2.02e-14 | 5.47e-12 | 120 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AMN | SNV | Missense_Mutation | c.391N>A | p.Asp131Asn | p.D131N | Q9BXJ7 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
AMN | deletion | Frame_Shift_Del | novel | c.409delN | p.Cys137AlafsTer62 | p.C137Afs*62 | Q9BXJ7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
AMN | SNV | Missense_Mutation | rs866956966 | c.193N>A | p.Ala65Thr | p.A65T | Q9BXJ7 | protein_coding | tolerated(0.21) | benign(0.09) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AMN | SNV | Missense_Mutation | c.86N>G | p.Asp29Gly | p.D29G | Q9BXJ7 | protein_coding | tolerated(0.06) | benign(0.086) | TCGA-EI-6511-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatinum+5-fu | SD | |
AMN | SNV | Missense_Mutation | c.56N>T | p.Ala19Val | p.A19V | Q9BXJ7 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
AMN | SNV | Missense_Mutation | novel | c.211C>A | p.Leu71Met | p.L71M | Q9BXJ7 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AMN | SNV | Missense_Mutation | novel | c.709N>A | p.Ala237Thr | p.A237T | Q9BXJ7 | protein_coding | tolerated(0.36) | benign(0.297) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AMN | SNV | Missense_Mutation | novel | c.763N>A | p.Ala255Thr | p.A255T | Q9BXJ7 | protein_coding | deleterious(0) | benign(0.346) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AMN | SNV | Missense_Mutation | c.401N>A | p.Arg134His | p.R134H | Q9BXJ7 | protein_coding | deleterious(0) | probably_damaging(0.933) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AMN | SNV | Missense_Mutation | c.86N>T | p.Asp29Val | p.D29V | Q9BXJ7 | protein_coding | deleterious(0) | benign(0.39) | TCGA-D1-A2G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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