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Gene: AHCYL1 |
Gene summary for AHCYL1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | AHCYL1 | Gene ID | 10768 |
Gene name | adenosylhomocysteinase like 1 | |
Gene Alias | DCAL | |
Cytomap | 1p13.3 | |
Gene Type | protein-coding | GO ID | GO:0002028 | UniProtAcc | O43865 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10768 | AHCYL1 | A002-C-016 | Human | Colorectum | FAP | 2.95e-10 | -2.16e-01 | 0.0521 |
10768 | AHCYL1 | A015-C-002 | Human | Colorectum | FAP | 2.06e-05 | -2.98e-01 | -0.0763 |
10768 | AHCYL1 | A001-C-203 | Human | Colorectum | FAP | 7.63e-03 | -2.23e-01 | -0.0481 |
10768 | AHCYL1 | A002-C-116 | Human | Colorectum | FAP | 1.39e-10 | -3.02e-01 | -0.0452 |
10768 | AHCYL1 | A014-C-008 | Human | Colorectum | FAP | 7.24e-07 | -3.03e-01 | -0.191 |
10768 | AHCYL1 | A018-E-020 | Human | Colorectum | FAP | 1.09e-08 | -2.69e-01 | -0.2034 |
10768 | AHCYL1 | F034 | Human | Colorectum | FAP | 4.44e-10 | -2.92e-01 | -0.0665 |
10768 | AHCYL1 | F072B | Human | Colorectum | FAP | 1.81e-03 | -2.10e-01 | 0.257 |
10768 | AHCYL1 | CRC-1-8810 | Human | Colorectum | CRC | 2.27e-03 | -1.94e-01 | 0.6257 |
10768 | AHCYL1 | CRC-3-11773 | Human | Colorectum | CRC | 6.40e-06 | -2.35e-01 | 0.2564 |
10768 | AHCYL1 | EEC-subject1 | Human | Endometrium | EEC | 2.32e-02 | 1.01e-03 | -0.2682 |
10768 | AHCYL1 | EEC-subject3 | Human | Endometrium | EEC | 9.63e-20 | -2.86e-01 | -0.2525 |
10768 | AHCYL1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.41e-24 | 2.64e-01 | -0.1869 |
10768 | AHCYL1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 6.92e-28 | 3.11e-01 | -0.1875 |
10768 | AHCYL1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.98e-31 | 3.41e-01 | -0.1883 |
10768 | AHCYL1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.26e-28 | 3.04e-01 | -0.1934 |
10768 | AHCYL1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.37e-44 | 2.71e-01 | -0.1917 |
10768 | AHCYL1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.12e-38 | 2.21e-01 | -0.1916 |
10768 | AHCYL1 | LZE4T | Human | Esophagus | ESCC | 7.48e-07 | 3.11e-01 | 0.0811 |
10768 | AHCYL1 | LZE20T | Human | Esophagus | ESCC | 8.97e-09 | 2.54e-02 | 0.0662 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0050684 | Colorectum | AD | regulation of mRNA processing | 61/3918 | 137/18723 | 4.23e-10 | 3.58e-08 | 61 |
GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0002028 | Colorectum | AD | regulation of sodium ion transport | 36/3918 | 90/18723 | 2.89e-05 | 5.37e-04 | 36 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0051168 | Colorectum | AD | nuclear export | 53/3918 | 154/18723 | 6.89e-05 | 1.11e-03 | 53 |
GO:0010765 | Colorectum | AD | positive regulation of sodium ion transport | 17/3918 | 35/18723 | 2.48e-04 | 3.13e-03 | 17 |
GO:0010038 | Colorectum | AD | response to metal ion | 106/3918 | 373/18723 | 3.22e-04 | 3.83e-03 | 106 |
GO:0006730 | Colorectum | AD | one-carbon metabolic process | 18/3918 | 40/18723 | 5.36e-04 | 5.74e-03 | 18 |
GO:0006611 | Colorectum | AD | protein export from nucleus | 23/3918 | 57/18723 | 6.62e-04 | 6.80e-03 | 23 |
GO:0022406 | Colorectum | AD | membrane docking | 31/3918 | 86/18723 | 8.67e-04 | 8.45e-03 | 31 |
GO:0140056 | Colorectum | AD | organelle localization by membrane tethering | 28/3918 | 77/18723 | 1.29e-03 | 1.14e-02 | 28 |
GO:19033111 | Colorectum | SER | regulation of mRNA metabolic process | 78/2897 | 288/18723 | 2.61e-07 | 1.43e-05 | 78 |
GO:00069131 | Colorectum | SER | nucleocytoplasmic transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00511691 | Colorectum | SER | nuclear transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00506841 | Colorectum | SER | regulation of mRNA processing | 42/2897 | 137/18723 | 5.57e-06 | 2.01e-04 | 42 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa002704 | Endometrium | EEC | Cysteine and methionine metabolism | 15/1237 | 52/8465 | 6.02e-03 | 3.12e-02 | 2.33e-02 | 15 |
hsa0027011 | Endometrium | EEC | Cysteine and methionine metabolism | 15/1237 | 52/8465 | 6.02e-03 | 3.12e-02 | 2.33e-02 | 15 |
hsa00270 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002701 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002702 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
hsa002703 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AHCYL1 | SNV | Missense_Mutation | novel | c.1148N>T | p.Glu383Val | p.E383V | O43865 | protein_coding | deleterious(0) | benign(0.062) | TCGA-B6-A3ZX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
AHCYL1 | SNV | Missense_Mutation | c.909N>T | p.Arg303Ser | p.R303S | O43865 | protein_coding | deleterious(0.02) | possibly_damaging(0.458) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
AHCYL1 | insertion | Frame_Shift_Ins | novel | c.899_899+1insCTCTCTTACTAGTACAGAAAGT | p.Leu301SerfsTer28 | p.L301Sfs*28 | O43865 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
AHCYL1 | SNV | Missense_Mutation | rs538566120 | c.1213N>A | p.Asp405Asn | p.D405N | O43865 | protein_coding | deleterious(0.03) | benign(0.429) | TCGA-C5-A1ME-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AHCYL1 | SNV | Missense_Mutation | novel | c.305N>A | p.Ser102Asn | p.S102N | O43865 | protein_coding | tolerated(0.51) | benign(0) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AHCYL1 | SNV | Missense_Mutation | novel | c.766G>A | p.Val256Met | p.V256M | O43865 | protein_coding | deleterious(0.03) | probably_damaging(0.92) | TCGA-VS-A950-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
AHCYL1 | SNV | Missense_Mutation | c.361G>A | p.Glu121Lys | p.E121K | O43865 | protein_coding | tolerated(0.07) | possibly_damaging(0.706) | TCGA-ZX-AA5X-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
AHCYL1 | SNV | Missense_Mutation | novel | c.821N>T | p.Pro274Leu | p.P274L | O43865 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
AHCYL1 | SNV | Missense_Mutation | c.409N>A | p.Ala137Thr | p.A137T | O43865 | protein_coding | tolerated(0.36) | benign(0.39) | TCGA-AA-3530-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AHCYL1 | SNV | Missense_Mutation | rs756700510 | c.641G>A | p.Arg214His | p.R214H | O43865 | protein_coding | deleterious(0.03) | benign(0.022) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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