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Gene: ADAT3 |
Gene summary for ADAT3 |
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Gene information | Species | Human | Gene symbol | ADAT3 | Gene ID | 113179 |
Gene name | adenosine deaminase tRNA specific 3 | |
Gene Alias | FWP005 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96EY9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
113179 | ADAT3 | P31T-E | Human | Esophagus | ESCC | 1.47e-11 | 2.63e-01 | 0.1251 |
113179 | ADAT3 | P32T-E | Human | Esophagus | ESCC | 1.03e-12 | 2.49e-01 | 0.1666 |
113179 | ADAT3 | P36T-E | Human | Esophagus | ESCC | 5.94e-05 | 1.57e-01 | 0.1187 |
113179 | ADAT3 | P37T-E | Human | Esophagus | ESCC | 1.96e-06 | 1.72e-01 | 0.1371 |
113179 | ADAT3 | P39T-E | Human | Esophagus | ESCC | 1.75e-07 | 1.26e-01 | 0.0894 |
113179 | ADAT3 | P40T-E | Human | Esophagus | ESCC | 1.27e-04 | 1.81e-01 | 0.109 |
113179 | ADAT3 | P42T-E | Human | Esophagus | ESCC | 1.86e-13 | 3.55e-01 | 0.1175 |
113179 | ADAT3 | P44T-E | Human | Esophagus | ESCC | 5.66e-05 | 1.71e-01 | 0.1096 |
113179 | ADAT3 | P47T-E | Human | Esophagus | ESCC | 8.42e-06 | 1.48e-01 | 0.1067 |
113179 | ADAT3 | P48T-E | Human | Esophagus | ESCC | 9.41e-06 | 1.92e-01 | 0.0959 |
113179 | ADAT3 | P49T-E | Human | Esophagus | ESCC | 2.53e-03 | 3.43e-01 | 0.1768 |
113179 | ADAT3 | P52T-E | Human | Esophagus | ESCC | 1.97e-13 | 2.36e-01 | 0.1555 |
113179 | ADAT3 | P54T-E | Human | Esophagus | ESCC | 2.25e-09 | 2.72e-01 | 0.0975 |
113179 | ADAT3 | P57T-E | Human | Esophagus | ESCC | 2.57e-05 | 1.84e-01 | 0.0926 |
113179 | ADAT3 | P61T-E | Human | Esophagus | ESCC | 3.44e-05 | 1.65e-01 | 0.099 |
113179 | ADAT3 | P62T-E | Human | Esophagus | ESCC | 4.13e-26 | 4.73e-01 | 0.1302 |
113179 | ADAT3 | P65T-E | Human | Esophagus | ESCC | 5.94e-03 | 1.34e-01 | 0.0978 |
113179 | ADAT3 | P74T-E | Human | Esophagus | ESCC | 2.15e-07 | 2.56e-01 | 0.1479 |
113179 | ADAT3 | P75T-E | Human | Esophagus | ESCC | 1.60e-19 | 3.81e-01 | 0.1125 |
113179 | ADAT3 | P76T-E | Human | Esophagus | ESCC | 2.38e-13 | 2.39e-01 | 0.1207 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAT3 | SNV | Missense_Mutation | novel | c.190N>T | p.Ala64Ser | p.A64S | protein_coding | deleterious(0.02) | possibly_damaging(0.726) | TCGA-A2-A3XS-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD | |
ADAT3 | SNV | Missense_Mutation | novel | c.1043N>T | p.Arg348Leu | p.R348L | protein_coding | deleterious(0.01) | possibly_damaging(0.548) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ADAT3 | SNV | Missense_Mutation | rs773656522 | c.1030N>A | p.Asp344Asn | p.D344N | protein_coding | tolerated(0.12) | benign(0.185) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
ADAT3 | SNV | Missense_Mutation | novel | c.832N>A | p.Ala278Thr | p.A278T | protein_coding | tolerated(0.55) | benign(0.131) | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | |
ADAT3 | SNV | Missense_Mutation | novel | c.868N>A | p.Gly290Ser | p.G290S | protein_coding | tolerated(0.16) | benign(0.019) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADAT3 | SNV | Missense_Mutation | novel | c.137N>T | p.Pro46Leu | p.P46L | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADAT3 | SNV | Missense_Mutation | rs756591965 | c.845N>A | p.Arg282His | p.R282H | protein_coding | tolerated(0.13) | benign(0.043) | TCGA-BB-A6UO-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ADAT3 | SNV | Missense_Mutation | c.1063N>A | p.Val355Met | p.V355M | protein_coding | deleterious(0) | benign(0.396) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ADAT3 | SNV | Missense_Mutation | c.931N>A | p.Ala311Thr | p.A311T | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ADAT3 | SNV | Missense_Mutation | novel | c.1027C>T | p.Pro343Ser | p.P343S | protein_coding | tolerated(0.13) | benign(0.056) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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