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Gene: ACBD6 |
Gene summary for ACBD6 |
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Gene information | Species | Human | Gene symbol | ACBD6 | Gene ID | 84320 |
Gene name | acyl-CoA binding domain containing 6 | |
Gene Alias | ACBD6 | |
Cytomap | 1q25.2-q25.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R915 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84320 | ACBD6 | A001-C-119 | Human | Colorectum | FAP | 1.85e-16 | -6.75e-01 | -0.1557 |
84320 | ACBD6 | A001-C-108 | Human | Colorectum | FAP | 5.96e-14 | -3.23e-01 | -0.0272 |
84320 | ACBD6 | A002-C-205 | Human | Colorectum | FAP | 3.37e-25 | -4.50e-01 | -0.1236 |
84320 | ACBD6 | A001-C-104 | Human | Colorectum | FAP | 1.42e-02 | -2.45e-01 | 0.0184 |
84320 | ACBD6 | A015-C-005 | Human | Colorectum | FAP | 1.55e-03 | -2.07e-01 | -0.0336 |
84320 | ACBD6 | A015-C-006 | Human | Colorectum | FAP | 3.13e-17 | -4.03e-01 | -0.0994 |
84320 | ACBD6 | A015-C-106 | Human | Colorectum | FAP | 4.72e-14 | -3.16e-01 | -0.0511 |
84320 | ACBD6 | A002-C-114 | Human | Colorectum | FAP | 6.61e-20 | -3.53e-01 | -0.1561 |
84320 | ACBD6 | A015-C-104 | Human | Colorectum | FAP | 2.43e-25 | -4.29e-01 | -0.1899 |
84320 | ACBD6 | A001-C-014 | Human | Colorectum | FAP | 5.38e-15 | -3.78e-01 | 0.0135 |
84320 | ACBD6 | A002-C-016 | Human | Colorectum | FAP | 4.80e-27 | -4.69e-01 | 0.0521 |
84320 | ACBD6 | A015-C-002 | Human | Colorectum | FAP | 1.20e-15 | -5.45e-01 | -0.0763 |
84320 | ACBD6 | A001-C-203 | Human | Colorectum | FAP | 4.02e-09 | -1.96e-01 | -0.0481 |
84320 | ACBD6 | A002-C-116 | Human | Colorectum | FAP | 1.07e-33 | -5.99e-01 | -0.0452 |
84320 | ACBD6 | A014-C-008 | Human | Colorectum | FAP | 6.17e-16 | -4.14e-01 | -0.191 |
84320 | ACBD6 | A018-E-020 | Human | Colorectum | FAP | 1.83e-23 | -4.55e-01 | -0.2034 |
84320 | ACBD6 | F034 | Human | Colorectum | FAP | 1.21e-20 | -3.42e-01 | -0.0665 |
84320 | ACBD6 | F072B | Human | Colorectum | FAP | 1.03e-10 | -3.46e-01 | 0.257 |
84320 | ACBD6 | CRC-1-8810 | Human | Colorectum | CRC | 1.82e-02 | 5.52e-02 | 0.6257 |
84320 | ACBD6 | CRC-3-11773 | Human | Colorectum | CRC | 3.54e-09 | -2.34e-01 | 0.2564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACBD6 | SNV | Missense_Mutation | rs762191597 | c.346G>A | p.Ala116Thr | p.A116T | Q9BR61 | protein_coding | tolerated(0.41) | possibly_damaging(0.849) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ACBD6 | SNV | Missense_Mutation | rs777457819 | c.539C>T | p.Ser180Leu | p.S180L | Q9BR61 | protein_coding | deleterious(0.03) | benign(0.005) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACBD6 | SNV | Missense_Mutation | c.659G>A | p.Cys220Tyr | p.C220Y | Q9BR61 | protein_coding | tolerated(0.81) | possibly_damaging(0.686) | TCGA-DC-6683-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
ACBD6 | insertion | Frame_Shift_Ins | novel | c.482_483insA | p.Asn161LysfsTer4 | p.N161Kfs*4 | Q9BR61 | protein_coding | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
ACBD6 | SNV | Missense_Mutation | novel | c.43A>G | p.Ser15Gly | p.S15G | Q9BR61 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACBD6 | SNV | Missense_Mutation | c.298A>G | p.Lys100Glu | p.K100E | Q9BR61 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ACBD6 | SNV | Missense_Mutation | c.610N>T | p.His204Tyr | p.H204Y | Q9BR61 | protein_coding | tolerated(0.09) | probably_damaging(0.996) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACBD6 | SNV | Missense_Mutation | novel | c.674N>A | p.Gly225Asp | p.G225D | Q9BR61 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACBD6 | SNV | Missense_Mutation | rs563966405 | c.761G>A | p.Arg254Gln | p.R254Q | Q9BR61 | protein_coding | tolerated(0.38) | probably_damaging(0.914) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
ACBD6 | SNV | Missense_Mutation | novel | c.277N>G | p.Lys93Glu | p.K93E | Q9BR61 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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