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Gene: ACBD5 |
Gene summary for ACBD5 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ACBD5 | Gene ID | 91452 |
Gene name | acyl-CoA binding domain containing 5 | |
Gene Alias | RDLKD | |
Cytomap | 10p12.1 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | B7Z2A7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91452 | ACBD5 | P1T-E | Human | Esophagus | ESCC | 6.99e-09 | 3.42e-01 | 0.0875 |
91452 | ACBD5 | P2T-E | Human | Esophagus | ESCC | 1.43e-12 | 2.28e-01 | 0.1177 |
91452 | ACBD5 | P4T-E | Human | Esophagus | ESCC | 4.50e-16 | 3.58e-01 | 0.1323 |
91452 | ACBD5 | P5T-E | Human | Esophagus | ESCC | 1.71e-13 | 2.17e-01 | 0.1327 |
91452 | ACBD5 | P8T-E | Human | Esophagus | ESCC | 1.56e-11 | 2.50e-01 | 0.0889 |
91452 | ACBD5 | P9T-E | Human | Esophagus | ESCC | 2.44e-08 | 2.05e-01 | 0.1131 |
91452 | ACBD5 | P10T-E | Human | Esophagus | ESCC | 3.42e-10 | 1.50e-01 | 0.116 |
91452 | ACBD5 | P11T-E | Human | Esophagus | ESCC | 2.79e-12 | 4.30e-01 | 0.1426 |
91452 | ACBD5 | P12T-E | Human | Esophagus | ESCC | 1.24e-15 | 3.33e-01 | 0.1122 |
91452 | ACBD5 | P15T-E | Human | Esophagus | ESCC | 2.32e-15 | 3.63e-01 | 0.1149 |
91452 | ACBD5 | P16T-E | Human | Esophagus | ESCC | 3.22e-14 | 2.68e-01 | 0.1153 |
91452 | ACBD5 | P17T-E | Human | Esophagus | ESCC | 8.24e-05 | 2.61e-01 | 0.1278 |
91452 | ACBD5 | P19T-E | Human | Esophagus | ESCC | 1.12e-06 | 3.82e-01 | 0.1662 |
91452 | ACBD5 | P20T-E | Human | Esophagus | ESCC | 1.67e-09 | 2.45e-01 | 0.1124 |
91452 | ACBD5 | P21T-E | Human | Esophagus | ESCC | 2.44e-24 | 4.94e-01 | 0.1617 |
91452 | ACBD5 | P22T-E | Human | Esophagus | ESCC | 6.84e-14 | 1.09e-01 | 0.1236 |
91452 | ACBD5 | P23T-E | Human | Esophagus | ESCC | 1.77e-07 | 2.26e-01 | 0.108 |
91452 | ACBD5 | P24T-E | Human | Esophagus | ESCC | 1.94e-07 | 1.62e-01 | 0.1287 |
91452 | ACBD5 | P26T-E | Human | Esophagus | ESCC | 6.51e-17 | 2.47e-01 | 0.1276 |
91452 | ACBD5 | P27T-E | Human | Esophagus | ESCC | 1.89e-13 | 2.53e-01 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACBD5 | SNV | Missense_Mutation | novel | c.347N>G | p.Met116Arg | p.M116R | Q5T8D3 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-A1-A0SK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ACBD5 | SNV | Missense_Mutation | novel | c.785N>T | p.Glu262Val | p.E262V | Q5T8D3 | protein_coding | tolerated(0.09) | benign(0.075) | TCGA-A7-A4SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ACBD5 | SNV | Missense_Mutation | novel | c.316N>A | p.Ser106Thr | p.S106T | Q5T8D3 | protein_coding | deleterious(0) | benign(0.281) | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
ACBD5 | SNV | Missense_Mutation | novel | c.314N>T | p.Ser105Ile | p.S105I | Q5T8D3 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
ACBD5 | SNV | Missense_Mutation | c.277T>C | p.Trp93Arg | p.W93R | Q5T8D3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ACBD5 | SNV | Missense_Mutation | novel | c.1099N>A | p.Glu367Lys | p.E367K | Q5T8D3 | protein_coding | tolerated(0.16) | probably_damaging(0.999) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ACBD5 | SNV | Missense_Mutation | c.1094N>T | p.Lys365Ile | p.K365I | Q5T8D3 | protein_coding | deleterious(0.01) | probably_damaging(0.957) | TCGA-A6-5662-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD | |
ACBD5 | SNV | Missense_Mutation | c.110N>G | p.Ala37Gly | p.A37G | Q5T8D3 | protein_coding | tolerated(0.13) | benign(0.089) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
ACBD5 | SNV | Missense_Mutation | novel | c.1180N>A | p.Phe394Ile | p.F394I | Q5T8D3 | protein_coding | tolerated(0.12) | benign(0.023) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ACBD5 | SNV | Missense_Mutation | rs755306488 | c.1024N>T | p.Arg342Cys | p.R342C | Q5T8D3 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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