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Gene: ACAP3 |
Gene summary for ACAP3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ACAP3 | Gene ID | 116983 |
Gene name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | |
Gene Alias | CENTB5 | |
Cytomap | 1p36.33 | |
Gene Type | protein-coding | GO ID | GO:0001764 | UniProtAcc | Q8WTZ1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116983 | ACAP3 | P23T-E | Human | Esophagus | ESCC | 1.99e-06 | 1.97e-01 | 0.108 |
116983 | ACAP3 | P24T-E | Human | Esophagus | ESCC | 2.25e-08 | 1.25e-01 | 0.1287 |
116983 | ACAP3 | P26T-E | Human | Esophagus | ESCC | 2.76e-11 | 1.19e-01 | 0.1276 |
116983 | ACAP3 | P27T-E | Human | Esophagus | ESCC | 2.55e-21 | 2.36e-01 | 0.1055 |
116983 | ACAP3 | P28T-E | Human | Esophagus | ESCC | 7.15e-21 | 3.53e-01 | 0.1149 |
116983 | ACAP3 | P30T-E | Human | Esophagus | ESCC | 8.41e-08 | 4.56e-01 | 0.137 |
116983 | ACAP3 | P31T-E | Human | Esophagus | ESCC | 6.51e-24 | 2.81e-01 | 0.1251 |
116983 | ACAP3 | P32T-E | Human | Esophagus | ESCC | 4.67e-10 | 1.95e-01 | 0.1666 |
116983 | ACAP3 | P37T-E | Human | Esophagus | ESCC | 1.06e-07 | 2.14e-01 | 0.1371 |
116983 | ACAP3 | P39T-E | Human | Esophagus | ESCC | 9.07e-16 | 1.61e-01 | 0.0894 |
116983 | ACAP3 | P40T-E | Human | Esophagus | ESCC | 2.27e-07 | 1.85e-01 | 0.109 |
116983 | ACAP3 | P42T-E | Human | Esophagus | ESCC | 7.63e-13 | 2.82e-01 | 0.1175 |
116983 | ACAP3 | P44T-E | Human | Esophagus | ESCC | 1.38e-04 | 1.27e-01 | 0.1096 |
116983 | ACAP3 | P47T-E | Human | Esophagus | ESCC | 6.31e-05 | 6.29e-02 | 0.1067 |
116983 | ACAP3 | P48T-E | Human | Esophagus | ESCC | 5.83e-14 | 1.80e-01 | 0.0959 |
116983 | ACAP3 | P49T-E | Human | Esophagus | ESCC | 1.83e-08 | 1.09e+00 | 0.1768 |
116983 | ACAP3 | P52T-E | Human | Esophagus | ESCC | 3.12e-23 | 4.44e-01 | 0.1555 |
116983 | ACAP3 | P54T-E | Human | Esophagus | ESCC | 3.04e-10 | 2.05e-01 | 0.0975 |
116983 | ACAP3 | P56T-E | Human | Esophagus | ESCC | 3.63e-03 | 3.37e-01 | 0.1613 |
116983 | ACAP3 | P57T-E | Human | Esophagus | ESCC | 1.66e-12 | 1.73e-01 | 0.0926 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:001097511 | Liver | HCC | regulation of neuron projection development | 220/7958 | 445/18723 | 1.68e-03 | 8.78e-03 | 220 |
GO:001097510 | Oral cavity | OSCC | regulation of neuron projection development | 210/7305 | 445/18723 | 2.35e-04 | 1.52e-03 | 210 |
GO:001097522 | Skin | cSCC | regulation of neuron projection development | 141/4864 | 445/18723 | 3.72e-03 | 1.99e-02 | 141 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414429 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144113 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACAP3 | SNV | Missense_Mutation | novel | c.391N>T | p.Asp131Tyr | p.D131Y | Q96P50 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
ACAP3 | SNV | Missense_Mutation | c.2152G>A | p.Val718Ile | p.V718I | Q96P50 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ACAP3 | SNV | Missense_Mutation | c.211N>A | p.Asp71Asn | p.D71N | Q96P50 | protein_coding | deleterious(0) | possibly_damaging(0.613) | TCGA-EW-A1IY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
ACAP3 | SNV | Missense_Mutation | rs532645854 | c.217N>A | p.Val73Ile | p.V73I | Q96P50 | protein_coding | tolerated(0.08) | benign(0.042) | TCGA-GM-A2DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
ACAP3 | SNV | Missense_Mutation | c.1687G>C | p.Val563Leu | p.V563L | Q96P50 | protein_coding | tolerated(0.48) | benign(0) | TCGA-DG-A2KL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ACAP3 | SNV | Missense_Mutation | c.680N>G | p.Ile227Ser | p.I227S | Q96P50 | protein_coding | tolerated(0.11) | benign(0.118) | TCGA-HM-A3JK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ACAP3 | SNV | Missense_Mutation | c.247N>A | p.Asp83Asn | p.D83N | Q96P50 | protein_coding | tolerated(0.12) | benign(0.197) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
ACAP3 | SNV | Missense_Mutation | rs765208758 | c.1099N>T | p.Arg367Cys | p.R367C | Q96P50 | protein_coding | deleterious(0) | possibly_damaging(0.794) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ACAP3 | SNV | Missense_Mutation | novel | c.1454C>T | p.Ala485Val | p.A485V | Q96P50 | protein_coding | deleterious(0) | benign(0.033) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
ACAP3 | SNV | Missense_Mutation | c.2096C>T | p.Ala699Val | p.A699V | Q96P50 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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