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Gene: ACAA2 |
Gene summary for ACAA2 |
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Gene information | Species | Human | Gene symbol | ACAA2 | Gene ID | 10449 |
Gene name | acetyl-CoA acyltransferase 2 | |
Gene Alias | DSAEC | |
Cytomap | 18q21.1 | |
Gene Type | protein-coding | GO ID | GO:0001666 | UniProtAcc | B3KNP8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10449 | ACAA2 | P2T-E | Human | Esophagus | ESCC | 5.59e-08 | 4.38e-02 | 0.1177 |
10449 | ACAA2 | P4T-E | Human | Esophagus | ESCC | 3.57e-17 | 4.28e-01 | 0.1323 |
10449 | ACAA2 | P8T-E | Human | Esophagus | ESCC | 3.12e-03 | -4.47e-02 | 0.0889 |
10449 | ACAA2 | P9T-E | Human | Esophagus | ESCC | 3.32e-02 | 7.92e-02 | 0.1131 |
10449 | ACAA2 | P10T-E | Human | Esophagus | ESCC | 3.57e-43 | 7.86e-01 | 0.116 |
10449 | ACAA2 | P16T-E | Human | Esophagus | ESCC | 5.87e-19 | 4.31e-01 | 0.1153 |
10449 | ACAA2 | P19T-E | Human | Esophagus | ESCC | 4.60e-07 | 6.29e-01 | 0.1662 |
10449 | ACAA2 | P21T-E | Human | Esophagus | ESCC | 1.21e-21 | 2.70e-01 | 0.1617 |
10449 | ACAA2 | P22T-E | Human | Esophagus | ESCC | 4.08e-02 | -4.87e-02 | 0.1236 |
10449 | ACAA2 | P24T-E | Human | Esophagus | ESCC | 2.73e-08 | 8.19e-02 | 0.1287 |
10449 | ACAA2 | P26T-E | Human | Esophagus | ESCC | 6.76e-36 | 7.25e-01 | 0.1276 |
10449 | ACAA2 | P28T-E | Human | Esophagus | ESCC | 2.95e-02 | -6.11e-02 | 0.1149 |
10449 | ACAA2 | P32T-E | Human | Esophagus | ESCC | 1.27e-06 | 2.62e-01 | 0.1666 |
10449 | ACAA2 | P37T-E | Human | Esophagus | ESCC | 1.16e-04 | 8.27e-02 | 0.1371 |
10449 | ACAA2 | P44T-E | Human | Esophagus | ESCC | 2.04e-04 | 1.24e-01 | 0.1096 |
10449 | ACAA2 | P56T-E | Human | Esophagus | ESCC | 1.05e-10 | 1.06e+00 | 0.1613 |
10449 | ACAA2 | P57T-E | Human | Esophagus | ESCC | 1.45e-04 | 1.30e-01 | 0.0926 |
10449 | ACAA2 | P74T-E | Human | Esophagus | ESCC | 2.88e-45 | 1.24e+00 | 0.1479 |
10449 | ACAA2 | P76T-E | Human | Esophagus | ESCC | 1.62e-22 | 3.33e-01 | 0.1207 |
10449 | ACAA2 | P79T-E | Human | Esophagus | ESCC | 1.84e-32 | 7.46e-01 | 0.1154 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0010821 | Colorectum | AD | regulation of mitochondrion organization | 57/3918 | 144/18723 | 2.43e-07 | 9.92e-06 | 57 |
GO:0007006 | Colorectum | AD | mitochondrial membrane organization | 48/3918 | 116/18723 | 4.53e-07 | 1.72e-05 | 48 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0006635 | Colorectum | AD | fatty acid beta-oxidation | 33/3918 | 74/18723 | 3.98e-06 | 1.09e-04 | 33 |
GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
GO:0008637 | Colorectum | AD | apoptotic mitochondrial changes | 42/3918 | 107/18723 | 1.13e-05 | 2.56e-04 | 42 |
GO:2001234 | Colorectum | AD | negative regulation of apoptotic signaling pathway | 74/3918 | 224/18723 | 1.49e-05 | 3.18e-04 | 74 |
GO:0019395 | Colorectum | AD | fatty acid oxidation | 40/3918 | 103/18723 | 2.43e-05 | 4.69e-04 | 40 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0072329 | Colorectum | AD | monocarboxylic acid catabolic process | 44/3918 | 122/18723 | 8.05e-05 | 1.28e-03 | 44 |
GO:0034440 | Colorectum | AD | lipid oxidation | 40/3918 | 108/18723 | 8.52e-05 | 1.32e-03 | 40 |
GO:0090559 | Colorectum | AD | regulation of membrane permeability | 31/3918 | 78/18723 | 1.16e-04 | 1.72e-03 | 31 |
GO:0030258 | Colorectum | AD | lipid modification | 67/3918 | 212/18723 | 1.66e-04 | 2.27e-03 | 67 |
GO:0016054 | Colorectum | AD | organic acid catabolic process | 73/3918 | 240/18723 | 3.20e-04 | 3.81e-03 | 73 |
GO:0044242 | Colorectum | AD | cellular lipid catabolic process | 66/3918 | 214/18723 | 3.96e-04 | 4.50e-03 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012129 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa0121214 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa0028021 | Liver | Cirrhotic | Valine, leucine and isoleucine degradation | 32/2530 | 48/8465 | 1.45e-07 | 2.02e-06 | 1.24e-06 | 32 |
hsa0007121 | Liver | Cirrhotic | Fatty acid degradation | 29/2530 | 43/8465 | 3.87e-07 | 4.95e-06 | 3.05e-06 | 29 |
hsa012122 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa0028031 | Liver | Cirrhotic | Valine, leucine and isoleucine degradation | 32/2530 | 48/8465 | 1.45e-07 | 2.02e-06 | 1.24e-06 | 32 |
hsa0007131 | Liver | Cirrhotic | Fatty acid degradation | 29/2530 | 43/8465 | 3.87e-07 | 4.95e-06 | 3.05e-06 | 29 |
hsa012123 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa0028041 | Liver | HCC | Valine, leucine and isoleucine degradation | 41/4020 | 48/8465 | 4.84e-08 | 7.05e-07 | 3.92e-07 | 41 |
hsa012124 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa0007141 | Liver | HCC | Fatty acid degradation | 33/4020 | 43/8465 | 8.41e-05 | 4.27e-04 | 2.37e-04 | 33 |
hsa0028051 | Liver | HCC | Valine, leucine and isoleucine degradation | 41/4020 | 48/8465 | 4.84e-08 | 7.05e-07 | 3.92e-07 | 41 |
hsa012125 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa0007151 | Liver | HCC | Fatty acid degradation | 33/4020 | 43/8465 | 8.41e-05 | 4.27e-04 | 2.37e-04 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACAA2 | SNV | Missense_Mutation | c.807N>C | p.Lys269Asn | p.K269N | P42765 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
ACAA2 | SNV | Missense_Mutation | c.41G>T | p.Arg14Leu | p.R14L | P42765 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A15M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ACAA2 | SNV | Missense_Mutation | c.1027N>A | p.Val343Met | p.V343M | P42765 | protein_coding | deleterious(0.05) | benign(0.257) | TCGA-EW-A1PB-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ACAA2 | SNV | Missense_Mutation | novel | c.17N>C | p.Gly6Ala | p.G6A | P42765 | protein_coding | tolerated(0.17) | benign(0.168) | TCGA-VS-A9U5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ACAA2 | SNV | Missense_Mutation | c.896N>T | p.Ala299Val | p.A299V | P42765 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ACAA2 | SNV | Missense_Mutation | rs745865904 | c.1102N>A | p.Glu368Lys | p.E368K | P42765 | protein_coding | deleterious(0.02) | possibly_damaging(0.477) | TCGA-F5-6813-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ACAA2 | SNV | Missense_Mutation | novel | c.633N>T | p.Lys211Asn | p.K211N | P42765 | protein_coding | deleterious(0) | possibly_damaging(0.846) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ACAA2 | SNV | Missense_Mutation | novel | c.800C>A | p.Ala267Asp | p.A267D | P42765 | protein_coding | tolerated(0.09) | possibly_damaging(0.866) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ACAA2 | SNV | Missense_Mutation | novel | c.317T>A | p.Ile106Asn | p.I106N | P42765 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACAA2 | SNV | Missense_Mutation | rs748770671 | c.752C>T | p.Ser251Leu | p.S251L | P42765 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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