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Gene: ABO |
Gene summary for ABO |
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Gene information | Species | Human | Gene symbol | ABO | Gene ID | 28 |
Gene name | ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase | |
Gene Alias | A3GALNT | |
Cytomap | 9q34.2 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A0A089QDC1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28 | ABO | A002-C-021 | Human | Colorectum | FAP | 3.16e-02 | -7.79e-02 | 0.1171 |
28 | ABO | A002-C-205 | Human | Colorectum | FAP | 2.19e-31 | -6.63e-01 | -0.1236 |
28 | ABO | A001-C-104 | Human | Colorectum | FAP | 1.74e-06 | -4.62e-01 | 0.0184 |
28 | ABO | A015-C-005 | Human | Colorectum | FAP | 3.92e-03 | -2.96e-01 | -0.0336 |
28 | ABO | A015-C-006 | Human | Colorectum | FAP | 3.13e-24 | -7.12e-01 | -0.0994 |
28 | ABO | A015-C-106 | Human | Colorectum | FAP | 6.29e-12 | -4.14e-01 | -0.0511 |
28 | ABO | A002-C-114 | Human | Colorectum | FAP | 1.43e-29 | -6.56e-01 | -0.1561 |
28 | ABO | A015-C-104 | Human | Colorectum | FAP | 3.12e-36 | -5.42e-01 | -0.1899 |
28 | ABO | A001-C-014 | Human | Colorectum | FAP | 1.64e-25 | -6.82e-01 | 0.0135 |
28 | ABO | A002-C-016 | Human | Colorectum | FAP | 4.79e-40 | -7.21e-01 | 0.0521 |
28 | ABO | A015-C-002 | Human | Colorectum | FAP | 1.23e-25 | -9.06e-01 | -0.0763 |
28 | ABO | A001-C-007 | Human | Colorectum | CRC | 5.15e-15 | -9.02e-01 | 0.1899 |
28 | ABO | A001-C-203 | Human | Colorectum | FAP | 2.09e-17 | -4.38e-01 | -0.0481 |
28 | ABO | A002-C-116 | Human | Colorectum | FAP | 3.52e-50 | -7.30e-01 | -0.0452 |
28 | ABO | A014-C-008 | Human | Colorectum | FAP | 8.13e-19 | -5.93e-01 | -0.191 |
28 | ABO | A018-E-020 | Human | Colorectum | FAP | 4.35e-29 | -6.05e-01 | -0.2034 |
28 | ABO | F034 | Human | Colorectum | FAP | 1.01e-28 | -5.10e-01 | -0.0665 |
28 | ABO | F072B | Human | Colorectum | FAP | 3.29e-12 | -4.00e-01 | 0.257 |
28 | ABO | CRC-1-8810 | Human | Colorectum | CRC | 5.39e-04 | -2.66e-01 | 0.6257 |
28 | ABO | CRC-3-11773 | Human | Colorectum | CRC | 1.50e-24 | -6.29e-01 | 0.2564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030258 | Colorectum | AD | lipid modification | 67/3918 | 212/18723 | 1.66e-04 | 2.27e-03 | 67 |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:00302581 | Colorectum | SER | lipid modification | 47/2897 | 212/18723 | 6.01e-03 | 4.38e-02 | 47 |
GO:00302582 | Colorectum | MSS | lipid modification | 57/3467 | 212/18723 | 1.64e-03 | 1.49e-02 | 57 |
GO:00302583 | Colorectum | FAP | lipid modification | 52/2622 | 212/18723 | 2.84e-05 | 6.49e-04 | 52 |
GO:00064861 | Colorectum | FAP | protein glycosylation | 48/2622 | 226/18723 | 1.85e-03 | 1.57e-02 | 48 |
GO:00434131 | Colorectum | FAP | macromolecule glycosylation | 48/2622 | 226/18723 | 1.85e-03 | 1.57e-02 | 48 |
GO:00700851 | Colorectum | FAP | glycosylation | 50/2622 | 240/18723 | 2.30e-03 | 1.85e-02 | 50 |
GO:0009101 | Colorectum | FAP | glycoprotein biosynthetic process | 63/2622 | 317/18723 | 2.31e-03 | 1.86e-02 | 63 |
GO:00302584 | Colorectum | CRC | lipid modification | 41/2078 | 212/18723 | 2.73e-04 | 4.38e-03 | 41 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00302586 | Esophagus | ESCC | lipid modification | 116/8552 | 212/18723 | 4.90e-03 | 1.89e-02 | 116 |
GO:00091001 | Oral cavity | OSCC | glycoprotein metabolic process | 185/7305 | 387/18723 | 2.37e-04 | 1.54e-03 | 185 |
GO:00091011 | Oral cavity | OSCC | glycoprotein biosynthetic process | 151/7305 | 317/18723 | 1.01e-03 | 5.26e-03 | 151 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABO | SNV | Missense_Mutation | novel | c.906N>T | p.Glu302Asp | p.E302D | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABO | SNV | Missense_Mutation | rs377147187 | c.434N>A | p.Arg145His | p.R145H | protein_coding | deleterious(0.02) | probably_damaging(0.981) | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ABO | insertion | In_Frame_Ins | novel | c.403_404insAGTACT | p.Thr135delinsLysTyrSer | p.T135delinsKYS | protein_coding | TCGA-A8-A090-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ABO | SNV | Missense_Mutation | rs370138477 | c.886N>A | p.Glu296Lys | p.E296K | protein_coding | deleterious(0.01) | possibly_damaging(0.686) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ABO | SNV | Missense_Mutation | novel | c.362N>A | p.Ala121Asp | p.A121D | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ABO | SNV | Missense_Mutation | novel | c.929N>C | p.Leu310Pro | p.L310P | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ABO | SNV | Missense_Mutation | rs866584466 | c.556N>T | p.Arg186Cys | p.R186C | protein_coding | deleterious(0.01) | probably_damaging(0.939) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABO | SNV | Missense_Mutation | rs781789696 | c.868N>A | p.Asp290Asn | p.D290N | protein_coding | deleterious(0.01) | probably_damaging(0.911) | TCGA-AD-A5EK-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ABO | SNV | Missense_Mutation | novel | c.586N>A | p.Glu196Lys | p.E196K | protein_coding | tolerated(0.41) | benign(0.043) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABO | SNV | Missense_Mutation | novel | c.481N>A | p.Val161Met | p.V161M | protein_coding | tolerated(0.07) | possibly_damaging(0.601) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
28 | ABO | NA | Ace Inhibitors, Plain | 21832968 | ||
28 | ABO | NA | hormonal contraceptives for systemic use | 28750087 |
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