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Gene: A1BG |
Gene summary for A1BG |
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Gene information | Species | Human | Gene symbol | A1BG | Gene ID | 1 |
Gene name | alpha-1-B glycoprotein | |
Gene Alias | A1B | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P04217 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1 | A1BG | P28T-E | Human | Esophagus | ESCC | 5.30e-21 | 4.01e-01 | 0.1149 |
1 | A1BG | P32T-E | Human | Esophagus | ESCC | 9.74e-22 | 3.98e-01 | 0.1666 |
1 | A1BG | P36T-E | Human | Esophagus | ESCC | 2.82e-02 | 1.18e-01 | 0.1187 |
1 | A1BG | P37T-E | Human | Esophagus | ESCC | 2.65e-33 | 8.05e-01 | 0.1371 |
1 | A1BG | P38T-E | Human | Esophagus | ESCC | 7.90e-12 | 4.23e-01 | 0.127 |
1 | A1BG | P42T-E | Human | Esophagus | ESCC | 2.42e-06 | 2.02e-01 | 0.1175 |
1 | A1BG | P44T-E | Human | Esophagus | ESCC | 3.00e-10 | 2.81e-01 | 0.1096 |
1 | A1BG | P48T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.27e-01 | 0.0959 |
1 | A1BG | P49T-E | Human | Esophagus | ESCC | 1.13e-17 | 1.36e+00 | 0.1768 |
1 | A1BG | P52T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.60e-01 | 0.1555 |
1 | A1BG | P56T-E | Human | Esophagus | ESCC | 5.32e-14 | 1.00e+00 | 0.1613 |
1 | A1BG | P57T-E | Human | Esophagus | ESCC | 9.67e-18 | 4.33e-01 | 0.0926 |
1 | A1BG | P61T-E | Human | Esophagus | ESCC | 5.03e-35 | 6.55e-01 | 0.099 |
1 | A1BG | P62T-E | Human | Esophagus | ESCC | 1.21e-03 | 1.05e-01 | 0.1302 |
1 | A1BG | P65T-E | Human | Esophagus | ESCC | 2.24e-16 | 3.35e-01 | 0.0978 |
1 | A1BG | P74T-E | Human | Esophagus | ESCC | 1.63e-30 | 6.79e-01 | 0.1479 |
1 | A1BG | P75T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.00e-01 | 0.1125 |
1 | A1BG | P76T-E | Human | Esophagus | ESCC | 3.52e-19 | 4.12e-01 | 0.1207 |
1 | A1BG | P79T-E | Human | Esophagus | ESCC | 2.78e-38 | 6.41e-01 | 0.1154 |
1 | A1BG | P82T-E | Human | Esophagus | ESCC | 8.26e-10 | 6.21e-01 | 0.1072 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
A1BG | SNV | Missense_Mutation | novel | c.327N>T | p.Glu109Asp | p.E109D | P04217 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |
A1BG | SNV | Missense_Mutation | rs151098196 | c.268C>T | p.Arg90Cys | p.R90C | P04217 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-E9-A1NH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
A1BG | insertion | In_Frame_Ins | novel | c.423_424insACCGGCTGCATGACA | p.Gly141_Val142insThrGlyCysMetThr | p.G141_V142insTGCMT | P04217 | protein_coding | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
A1BG | SNV | Missense_Mutation | rs533605370 | c.281G>A | p.Arg94His | p.R94H | P04217 | protein_coding | deleterious(0.03) | possibly_damaging(0.793) | TCGA-BI-A0VS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
A1BG | SNV | Missense_Mutation | c.1354N>A | p.Ala452Thr | p.A452T | P04217 | protein_coding | tolerated(0.15) | benign(0.028) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
A1BG | SNV | Missense_Mutation | rs375725715 | c.365N>T | p.Ser122Leu | p.S122L | P04217 | protein_coding | deleterious(0.03) | benign(0.267) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
A1BG | SNV | Missense_Mutation | rs540868706 | c.571N>A | p.Ala191Thr | p.A191T | P04217 | protein_coding | tolerated(0.64) | benign(0.011) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
A1BG | SNV | Missense_Mutation | rs770480372 | c.781C>T | p.Arg261Cys | p.R261C | P04217 | protein_coding | deleterious(0.01) | probably_damaging(0.982) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
A1BG | SNV | Missense_Mutation | c.545N>A | p.Cys182Tyr | p.C182Y | P04217 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
A1BG | SNV | Missense_Mutation | rs540868706 | c.571N>A | p.Ala191Thr | p.A191T | P04217 | protein_coding | tolerated(0.64) | benign(0.011) | TCGA-D5-6531-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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