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Gene: DBI |
Gene summary for DBI |
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Gene information | Species | Human | Gene symbol | DBI | Gene ID | 1622 |
Gene name | diazepam binding inhibitor, acyl-CoA binding protein | |
Gene Alias | ACBD1 | |
Cytomap | 2q14.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | P07108 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1622 | DBI | Pat26-A | Human | Stomach | CSG | 2.10e-81 | -8.51e-02 | -0.2402 |
1622 | DBI | Pat28-A | Human | Stomach | CSG | 4.89e-31 | 4.11e-03 | -0.2594 |
1622 | DBI | Pat29-A | Human | Stomach | CAG with IM | 2.04e-23 | -5.07e-02 | -0.2769 |
1622 | DBI | NAG_1 | Human | Stomach | CSG | 7.33e-10 | -5.10e-01 | -0.3534 |
1622 | DBI | NAG_2 | Human | Stomach | CSG | 1.69e-14 | -2.77e-01 | -0.3324 |
1622 | DBI | NAG_3 | Human | Stomach | CSG | 5.76e-06 | -2.19e-01 | -0.2816 |
1622 | DBI | CAG_1 | Human | Stomach | CAG | 1.66e-07 | -8.86e-01 | -0.3206 |
1622 | DBI | CAG_2 | Human | Stomach | CAG | 3.08e-14 | -4.85e-01 | -0.2831 |
1622 | DBI | CAG_3 | Human | Stomach | CAG | 1.26e-17 | -3.54e-01 | -0.2766 |
1622 | DBI | WIM_1 | Human | Stomach | WIM | 3.08e-09 | -2.48e-01 | 0.0335 |
1622 | DBI | WIM_2 | Human | Stomach | WIM | 3.53e-10 | -4.51e-01 | 0.1159 |
1622 | DBI | SIM_1 | Human | Stomach | SIM | 4.53e-08 | -1.45e-01 | 0.3573 |
1622 | DBI | SIM_2 | Human | Stomach | SIM | 4.61e-15 | -2.01e-01 | 0.3139 |
1622 | DBI | SIM_3 | Human | Stomach | SIM | 2.79e-18 | -6.43e-01 | 0.0345 |
1622 | DBI | SIM_4 | Human | Stomach | SIM | 6.67e-14 | -5.79e-01 | 0.2664 |
1622 | DBI | EGC | Human | Stomach | GC | 2.67e-27 | -7.13e-01 | 0.1683 |
1622 | DBI | Pt1_Superficial | Human | Stomach | GC | 6.63e-07 | -5.65e-01 | 0.1036 |
1622 | DBI | Adj_PTCwithHT_6 | Human | Thyroid | HT | 1.90e-02 | -2.77e-01 | 0.02 |
1622 | DBI | PTCwithoutHT_2 | Human | Thyroid | PTC | 9.20e-06 | -5.31e-01 | 0.0419 |
1622 | DBI | male-WTA | Human | Thyroid | PTC | 7.47e-68 | -3.55e-01 | 0.1037 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00066501 | Colorectum | SER | glycerophospholipid metabolic process | 64/2897 | 306/18723 | 6.41e-03 | 4.60e-02 | 64 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00421573 | Esophagus | ESCC | lipoprotein metabolic process | 86/8552 | 135/18723 | 1.78e-05 | 1.57e-04 | 86 |
GO:00064973 | Esophagus | ESCC | protein lipidation | 62/8552 | 92/18723 | 2.08e-05 | 1.80e-04 | 62 |
GO:00421583 | Esophagus | ESCC | lipoprotein biosynthetic process | 64/8552 | 96/18723 | 2.61e-05 | 2.20e-04 | 64 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:0042157 | Liver | Cirrhotic | lipoprotein metabolic process | 53/4634 | 135/18723 | 1.32e-04 | 1.29e-03 | 53 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
GO:19059521 | Liver | Cirrhotic | regulation of lipid localization | 62/4634 | 181/18723 | 2.53e-03 | 1.51e-02 | 62 |
GO:0042158 | Liver | Cirrhotic | lipoprotein biosynthetic process | 36/4634 | 96/18723 | 3.69e-03 | 2.03e-02 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0332021 | Liver | Cirrhotic | PPAR signaling pathway | 32/2530 | 75/8465 | 1.24e-02 | 3.92e-02 | 2.42e-02 | 32 |
hsa0332031 | Liver | Cirrhotic | PPAR signaling pathway | 32/2530 | 75/8465 | 1.24e-02 | 3.92e-02 | 2.42e-02 | 32 |
hsa033204 | Liver | HCC | PPAR signaling pathway | 48/4020 | 75/8465 | 2.83e-03 | 9.37e-03 | 5.21e-03 | 48 |
hsa033205 | Liver | HCC | PPAR signaling pathway | 48/4020 | 75/8465 | 2.83e-03 | 9.37e-03 | 5.21e-03 | 48 |
hsa03320 | Stomach | GC | PPAR signaling pathway | 18/708 | 75/8465 | 3.26e-05 | 4.01e-04 | 2.82e-04 | 18 |
hsa033201 | Stomach | GC | PPAR signaling pathway | 18/708 | 75/8465 | 3.26e-05 | 4.01e-04 | 2.82e-04 | 18 |
hsa033202 | Stomach | SIM | PPAR signaling pathway | 15/465 | 75/8465 | 1.08e-05 | 1.42e-04 | 1.14e-04 | 15 |
hsa033203 | Stomach | SIM | PPAR signaling pathway | 15/465 | 75/8465 | 1.08e-05 | 1.42e-04 | 1.14e-04 | 15 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DBI | SNV | Missense_Mutation | c.429N>T | p.Lys143Asn | p.K143N | P07108 | protein_coding | tolerated(0.12) | possibly_damaging(0.895) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DBI | SNV | Missense_Mutation | novel | c.202N>C | p.Glu68Gln | p.E68Q | P07108 | protein_coding | deleterious(0.04) | benign(0.261) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DBI | SNV | Missense_Mutation | rs772399235 | c.132G>T | p.Gln44His | p.Q44H | P07108 | protein_coding | tolerated_low_confidence(0.14) | benign(0.364) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DBI | SNV | Missense_Mutation | c.429N>T | p.Lys143Asn | p.K143N | P07108 | protein_coding | tolerated(0.12) | possibly_damaging(0.895) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
DBI | deletion | Frame_Shift_Del | c.435delA | p.Lys145AsnfsTer27 | p.K145Nfs*27 | P07108 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
DBI | insertion | Frame_Shift_Ins | novel | c.435dupA | p.Tyr146IlefsTer19 | p.Y146Ifs*19 | P07108 | protein_coding | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | ||
DBI | SNV | Missense_Mutation | novel | c.362A>C | p.Asn121Thr | p.N121T | P07108 | protein_coding | deleterious(0.02) | possibly_damaging(0.574) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
DBI | SNV | Missense_Mutation | novel | c.49N>G | p.Ser17Ala | p.S17A | P07108 | protein_coding | unknown(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DBI | SNV | Missense_Mutation | c.431N>C | p.Lys144Thr | p.K144T | P07108 | protein_coding | tolerated(0.08) | benign(0.18) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DBI | SNV | Missense_Mutation | novel | c.71N>T | p.Arg24Met | p.R24M | P07108 | protein_coding | deleterious_low_confidence(0) | benign(0.157) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1622 | DBI | NA | HORMONES | 9712181 |
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