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Gene: USMG5 |
Gene summary for USMG5 |
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Gene information | Species | Human | Gene symbol | USMG5 | Gene ID | 84833 |
Gene name | ATP synthase membrane subunit k | |
Gene Alias | AGP | |
Cytomap | 10q24.33 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96IX5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84833 | USMG5 | female-WTA | Human | Thyroid | PTC | 3.73e-14 | -1.05e+00 | 0.0726 |
84833 | USMG5 | nodule-WTA | Human | Thyroid | goiters | 4.71e-29 | -1.05e+00 | 0.0534 |
84833 | USMG5 | PTC01 | Human | Thyroid | PTC | 3.07e-41 | -1.05e+00 | 0.1899 |
84833 | USMG5 | PTC03 | Human | Thyroid | PTC | 3.33e-11 | -1.05e+00 | 0.1784 |
84833 | USMG5 | PTC04 | Human | Thyroid | PTC | 7.21e-44 | -1.05e+00 | 0.1927 |
84833 | USMG5 | PTC05 | Human | Thyroid | PTC | 1.23e-11 | -1.05e+00 | 0.2065 |
84833 | USMG5 | PTC06 | Human | Thyroid | PTC | 6.20e-23 | -1.05e+00 | 0.2057 |
84833 | USMG5 | PTC07 | Human | Thyroid | PTC | 3.04e-38 | -1.05e+00 | 0.2044 |
84833 | USMG5 | ATC08 | Human | Thyroid | ATC | 1.28e-10 | -1.05e+00 | 0.0541 |
84833 | USMG5 | ATC09 | Human | Thyroid | ATC | 4.57e-12 | -1.05e+00 | 0.2871 |
84833 | USMG5 | ATC11 | Human | Thyroid | ATC | 3.09e-02 | -1.05e+00 | 0.3386 |
84833 | USMG5 | ATC12 | Human | Thyroid | ATC | 7.21e-44 | -1.05e+00 | 0.34 |
84833 | USMG5 | ATC13 | Human | Thyroid | ATC | 5.57e-37 | -1.05e+00 | 0.34 |
84833 | USMG5 | ATC1 | Human | Thyroid | ATC | 4.99e-10 | -1.05e+00 | 0.2878 |
84833 | USMG5 | ATC2 | Human | Thyroid | ATC | 3.09e-02 | -1.05e+00 | 0.34 |
84833 | USMG5 | ATC3 | Human | Thyroid | ATC | 1.73e-04 | -1.05e+00 | 0.338 |
84833 | USMG5 | ATC4 | Human | Thyroid | ATC | 9.58e-32 | -1.05e+00 | 0.34 |
84833 | USMG5 | ATC5 | Human | Thyroid | ATC | 6.03e-40 | -1.05e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USMG5 | deletion | Frame_Shift_Del | c.154delN | p.Thr52LeufsTer4 | p.T52Lfs*4 | Q96IX5 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
USMG5 | deletion | Frame_Shift_Del | c.51delN | p.Lys17AsnfsTer12 | p.K17Nfs*12 | Q96IX5 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
USMG5 | SNV | Missense_Mutation | novel | c.36N>A | p.Phe12Leu | p.F12L | Q96IX5 | protein_coding | tolerated(0.39) | probably_damaging(0.987) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
USMG5 | SNV | Missense_Mutation | novel | c.104N>G | p.Tyr35Cys | p.Y35C | Q96IX5 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EY-A1H0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
USMG5 | deletion | Frame_Shift_Del | c.154delN | p.Thr52LeufsTer4 | p.T52Lfs*4 | Q96IX5 | protein_coding | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |||
USMG5 | deletion | Frame_Shift_Del | c.51delA | p.Lys17AsnfsTer12 | p.K17Nfs*12 | Q96IX5 | protein_coding | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |||
USMG5 | insertion | Frame_Shift_Ins | novel | c.154dupA | p.Thr52AsnfsTer12 | p.T52Nfs*12 | Q96IX5 | protein_coding | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
USMG5 | SNV | Missense_Mutation | novel | c.57N>A | p.Phe19Leu | p.F19L | Q96IX5 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-98-8022-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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