![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TCEB2 |
Gene summary for TCEB2 |
![]() |
Gene information | Species | Human | Gene symbol | TCEB2 | Gene ID | 6923 |
Gene name | elongin B | |
Gene Alias | SIII | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q15370 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6923 | TCEB2 | PTCwithHT_6 | Human | Thyroid | HT | 1.55e-03 | -2.71e-01 | 0.02 |
6923 | TCEB2 | PTCwithHT_8 | Human | Thyroid | HT | 3.84e-05 | -2.95e-01 | 0.0351 |
6923 | TCEB2 | PTCwithoutHT_2 | Human | Thyroid | PTC | 1.54e-04 | -1.51e-01 | 0.0419 |
6923 | TCEB2 | male-WTA | Human | Thyroid | PTC | 6.99e-29 | -9.35e-01 | 0.1037 |
6923 | TCEB2 | female-WTA | Human | Thyroid | PTC | 6.26e-11 | -9.35e-01 | 0.0726 |
6923 | TCEB2 | nodule-WTA | Human | Thyroid | goiters | 3.04e-23 | -9.35e-01 | 0.0534 |
6923 | TCEB2 | PTC01 | Human | Thyroid | PTC | 4.60e-30 | -9.35e-01 | 0.1899 |
6923 | TCEB2 | PTC03 | Human | Thyroid | PTC | 1.68e-08 | -9.35e-01 | 0.1784 |
6923 | TCEB2 | PTC04 | Human | Thyroid | PTC | 1.14e-29 | -9.35e-01 | 0.1927 |
6923 | TCEB2 | PTC05 | Human | Thyroid | PTC | 7.39e-09 | -9.35e-01 | 0.2065 |
6923 | TCEB2 | PTC06 | Human | Thyroid | PTC | 3.55e-18 | -9.35e-01 | 0.2057 |
6923 | TCEB2 | PTC07 | Human | Thyroid | PTC | 6.99e-29 | -9.35e-01 | 0.2044 |
6923 | TCEB2 | ATC08 | Human | Thyroid | ATC | 5.07e-08 | -9.35e-01 | 0.0541 |
6923 | TCEB2 | ATC09 | Human | Thyroid | ATC | 3.28e-09 | -9.35e-01 | 0.2871 |
6923 | TCEB2 | ATC12 | Human | Thyroid | ATC | 1.17e-31 | -9.35e-01 | 0.34 |
6923 | TCEB2 | ATC13 | Human | Thyroid | ATC | 6.99e-29 | -9.35e-01 | 0.34 |
6923 | TCEB2 | ATC1 | Human | Thyroid | ATC | 1.55e-07 | -9.35e-01 | 0.2878 |
6923 | TCEB2 | ATC3 | Human | Thyroid | ATC | 5.49e-03 | -9.35e-01 | 0.338 |
6923 | TCEB2 | ATC4 | Human | Thyroid | ATC | 1.78e-25 | -9.35e-01 | 0.34 |
6923 | TCEB2 | ATC5 | Human | Thyroid | ATC | 4.23e-28 | -9.35e-01 | 0.34 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0406616 | Breast | Precancer | HIF-1 signaling pathway | 23/684 | 109/8465 | 1.51e-05 | 1.59e-04 | 1.22e-04 | 23 |
hsa0406617 | Breast | Precancer | HIF-1 signaling pathway | 23/684 | 109/8465 | 1.51e-05 | 1.59e-04 | 1.22e-04 | 23 |
hsa0406623 | Breast | IDC | HIF-1 signaling pathway | 22/867 | 109/8465 | 1.36e-03 | 1.00e-02 | 7.50e-03 | 22 |
hsa0517014 | Breast | IDC | Human immunodeficiency virus 1 infection | 33/867 | 212/8465 | 9.28e-03 | 4.37e-02 | 3.27e-02 | 33 |
hsa0406633 | Breast | IDC | HIF-1 signaling pathway | 22/867 | 109/8465 | 1.36e-03 | 1.00e-02 | 7.50e-03 | 22 |
hsa0517015 | Breast | IDC | Human immunodeficiency virus 1 infection | 33/867 | 212/8465 | 9.28e-03 | 4.37e-02 | 3.27e-02 | 33 |
hsa0406642 | Breast | DCIS | HIF-1 signaling pathway | 22/846 | 109/8465 | 9.83e-04 | 7.05e-03 | 5.20e-03 | 22 |
hsa0517024 | Breast | DCIS | Human immunodeficiency virus 1 infection | 33/846 | 212/8465 | 6.49e-03 | 3.22e-02 | 2.37e-02 | 33 |
hsa0521123 | Breast | DCIS | Renal cell carcinoma | 14/846 | 69/8465 | 7.42e-03 | 3.48e-02 | 2.56e-02 | 14 |
hsa0406652 | Breast | DCIS | HIF-1 signaling pathway | 22/846 | 109/8465 | 9.83e-04 | 7.05e-03 | 5.20e-03 | 22 |
hsa0517034 | Breast | DCIS | Human immunodeficiency virus 1 infection | 33/846 | 212/8465 | 6.49e-03 | 3.22e-02 | 2.37e-02 | 33 |
hsa0521133 | Breast | DCIS | Renal cell carcinoma | 14/846 | 69/8465 | 7.42e-03 | 3.48e-02 | 2.56e-02 | 14 |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0517016 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa052119 | Cervix | CC | Renal cell carcinoma | 20/1267 | 69/8465 | 2.07e-03 | 8.17e-03 | 4.83e-03 | 20 |
hsa0406618 | Cervix | CC | HIF-1 signaling pathway | 27/1267 | 109/8465 | 4.72e-03 | 1.64e-02 | 9.72e-03 | 27 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0517017 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa0521114 | Cervix | CC | Renal cell carcinoma | 20/1267 | 69/8465 | 2.07e-03 | 8.17e-03 | 4.83e-03 | 20 |
hsa0406619 | Cervix | CC | HIF-1 signaling pathway | 27/1267 | 109/8465 | 4.72e-03 | 1.64e-02 | 9.72e-03 | 27 |
Page: 1 2 3 4 5 6 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |