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Gene: HNRNPC |
Gene summary for HNRNPC |
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Gene information | Species | Human | Gene symbol | HNRNPC | Gene ID | 3183 |
Gene name | heterogeneous nuclear ribonucleoprotein C | |
Gene Alias | C1 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P07910 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3183 | HNRNPC | Pat02-B | Human | Stomach | GC | 1.86e-71 | -1.82e-01 | 0.0368 |
3183 | HNRNPC | Pat03-B | Human | Stomach | GC | 5.84e-51 | -2.97e-01 | 0.3693 |
3183 | HNRNPC | Pat04-B | Human | Stomach | GC | 1.22e-52 | -7.36e-04 | -0.1483 |
3183 | HNRNPC | Pat05-B | Human | Stomach | GC | 5.91e-24 | -2.23e-01 | -0.0353 |
3183 | HNRNPC | Pat06-B | Human | Stomach | GC | 6.34e-74 | -5.08e-02 | -0.1961 |
3183 | HNRNPC | Pat07-B | Human | Stomach | GC | 2.07e-05 | -2.41e-01 | 0.0935 |
3183 | HNRNPC | Pat08-B | Human | Stomach | GC | 3.81e-05 | -2.21e-01 | 0.0182 |
3183 | HNRNPC | Pat09-B | Human | Stomach | GC | 2.39e-15 | -2.74e-02 | -0.0359 |
3183 | HNRNPC | Pat10-B | Human | Stomach | GC | 2.98e-07 | -5.13e-01 | 0.084 |
3183 | HNRNPC | Pat11-B | Human | Stomach | GC | 1.43e-31 | 1.74e-02 | -0.182 |
3183 | HNRNPC | Pat12-B | Human | Stomach | GC | 1.33e-49 | -1.84e-01 | 0.0325 |
3183 | HNRNPC | Pat13-B | Human | Stomach | GC | 6.14e-16 | -6.51e-02 | 0.0555 |
3183 | HNRNPC | Pat15-B | Human | Stomach | GC | 5.04e-29 | -1.00e-01 | -0.0778 |
3183 | HNRNPC | Pat16-B | Human | Stomach | GC | 1.32e-17 | -2.74e-01 | 0.1918 |
3183 | HNRNPC | Pat17-B | Human | Stomach | GC | 4.35e-10 | -3.36e-01 | 0.3109 |
3183 | HNRNPC | Pat18-B | Human | Stomach | GC | 4.91e-31 | -2.68e-01 | -0.0432 |
3183 | HNRNPC | Pat19-B | Human | Stomach | GC | 4.38e-30 | -3.04e-01 | 0.0826 |
3183 | HNRNPC | Pat22-B | Human | Stomach | GC | 1.38e-59 | -9.17e-02 | -0.1042 |
3183 | HNRNPC | Pat24-B | Human | Stomach | GC | 5.29e-26 | -1.71e-01 | -0.1184 |
3183 | HNRNPC | Pat25-A | Human | Stomach | CAG with IM | 3.63e-60 | -1.26e-01 | -0.1648 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:19033118 | Breast | Precancer | regulation of mRNA metabolic process | 38/1080 | 288/18723 | 1.63e-06 | 5.97e-05 | 38 |
GO:00313309 | Breast | Precancer | negative regulation of cellular catabolic process | 34/1080 | 262/18723 | 8.16e-06 | 2.20e-04 | 34 |
GO:00064028 | Breast | Precancer | mRNA catabolic process | 31/1080 | 232/18723 | 1.12e-05 | 2.93e-04 | 31 |
GO:00064018 | Breast | Precancer | RNA catabolic process | 34/1080 | 278/18723 | 2.88e-05 | 6.39e-04 | 34 |
GO:00108338 | Breast | Precancer | telomere maintenance via telomere lengthening | 15/1080 | 81/18723 | 5.31e-05 | 1.11e-03 | 15 |
GO:00007238 | Breast | Precancer | telomere maintenance | 20/1080 | 131/18723 | 6.10e-05 | 1.25e-03 | 20 |
GO:19033129 | Breast | Precancer | negative regulation of mRNA metabolic process | 16/1080 | 92/18723 | 6.70e-05 | 1.35e-03 | 16 |
GO:00098959 | Breast | Precancer | negative regulation of catabolic process | 36/1080 | 320/18723 | 9.92e-05 | 1.83e-03 | 36 |
GO:00070047 | Breast | Precancer | telomere maintenance via telomerase | 13/1080 | 69/18723 | 1.37e-04 | 2.38e-03 | 13 |
GO:19043567 | Breast | Precancer | regulation of telomere maintenance via telomere lengthening | 12/1080 | 61/18723 | 1.61e-04 | 2.69e-03 | 12 |
GO:00346558 | Breast | Precancer | nucleobase-containing compound catabolic process | 42/1080 | 407/18723 | 1.91e-04 | 3.06e-03 | 42 |
GO:00062786 | Breast | Precancer | RNA-dependent DNA biosynthetic process | 13/1080 | 75/18723 | 3.27e-04 | 4.64e-03 | 13 |
GO:00016496 | Breast | Precancer | osteoblast differentiation | 27/1080 | 229/18723 | 3.35e-04 | 4.73e-03 | 27 |
GO:00467007 | Breast | Precancer | heterocycle catabolic process | 44/1080 | 445/18723 | 3.49e-04 | 4.88e-03 | 44 |
GO:20002788 | Breast | Precancer | regulation of DNA biosynthetic process | 16/1080 | 106/18723 | 3.68e-04 | 5.03e-03 | 16 |
GO:00442708 | Breast | Precancer | cellular nitrogen compound catabolic process | 44/1080 | 451/18723 | 4.64e-04 | 6.12e-03 | 44 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030408 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304013 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304023 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304033 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304043 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa0304053 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030404 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030405 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304024 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304034 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPC | SNV | Missense_Mutation | rs199624650 | c.742N>C | p.Asn248His | p.N248H | P07910 | protein_coding | tolerated(0.21) | benign(0) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HNRNPC | SNV | Missense_Mutation | c.571G>A | p.Asp191Asn | p.D191N | P07910 | protein_coding | tolerated(0.15) | probably_damaging(0.94) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
HNRNPC | SNV | Missense_Mutation | c.545N>A | p.Ser182Tyr | p.S182Y | P07910 | protein_coding | deleterious(0.01) | probably_damaging(0.949) | TCGA-OL-A5D6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HNRNPC | SNV | Missense_Mutation | novel | c.188C>G | p.Ala63Gly | p.A63G | P07910 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
HNRNPC | SNV | Missense_Mutation | c.913N>A | p.Asp305Asn | p.D305N | P07910 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.971) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HNRNPC | SNV | Missense_Mutation | novel | c.309N>T | p.Glu103Asp | p.E103D | P07910 | protein_coding | tolerated(0.41) | benign(0.003) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HNRNPC | SNV | Missense_Mutation | c.299C>A | p.Ser100Tyr | p.S100Y | P07910 | protein_coding | deleterious(0) | benign(0.009) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HNRNPC | SNV | Missense_Mutation | c.32N>T | p.Pro11Leu | p.P11L | P07910 | protein_coding | deleterious(0) | benign(0.414) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HNRNPC | SNV | Missense_Mutation | novel | c.793N>A | p.Asp265Asn | p.D265N | P07910 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HNRNPC | insertion | Frame_Shift_Ins | novel | c.440_441insC | p.Pro148SerfsTer29 | p.P148Sfs*29 | P07910 | protein_coding | TCGA-AD-6548-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3183 | HNRNPC | NA | DABIGATRAN | DABIGATRAN | 22494098 |
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