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Gene: MZT2B |
Gene summary for MZT2B |
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Gene information | Species | Human | Gene symbol | MZT2B | Gene ID | 80097 |
Gene name | mitotic spindle organizing protein 2B | |
Gene Alias | FAM128B | |
Cytomap | 2q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000930 | UniProtAcc | B8ZZ87 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80097 | MZT2B | WIM_2 | Human | Stomach | WIM | 5.49e-07 | 6.26e-01 | 0.1159 |
80097 | MZT2B | SIM_2 | Human | Stomach | SIM | 7.17e-17 | 6.14e-01 | 0.3139 |
80097 | MZT2B | male-WTA | Human | Thyroid | PTC | 1.06e-62 | 3.26e-01 | 0.1037 |
80097 | MZT2B | PTC01 | Human | Thyroid | PTC | 7.68e-36 | 1.23e+00 | 0.1899 |
80097 | MZT2B | PTC03 | Human | Thyroid | PTC | 3.06e-02 | 1.09e+00 | 0.1784 |
80097 | MZT2B | PTC04 | Human | Thyroid | PTC | 3.63e-12 | 6.63e-01 | 0.1927 |
80097 | MZT2B | PTC05 | Human | Thyroid | PTC | 6.84e-34 | 2.08e+00 | 0.2065 |
80097 | MZT2B | PTC06 | Human | Thyroid | PTC | 8.25e-55 | 2.18e+00 | 0.2057 |
80097 | MZT2B | PTC07 | Human | Thyroid | PTC | 1.37e-84 | 1.93e+00 | 0.2044 |
80097 | MZT2B | ATC08 | Human | Thyroid | ATC | 1.26e-13 | 2.96e-01 | 0.0541 |
80097 | MZT2B | ATC09 | Human | Thyroid | ATC | 1.89e-16 | 3.34e-01 | 0.2871 |
80097 | MZT2B | ATC11 | Human | Thyroid | ATC | 3.90e-14 | 2.27e+00 | 0.3386 |
80097 | MZT2B | ATC12 | Human | Thyroid | ATC | 5.06e-51 | 1.17e+00 | 0.34 |
80097 | MZT2B | ATC13 | Human | Thyroid | ATC | 1.27e-46 | 1.80e+00 | 0.34 |
80097 | MZT2B | ATC1 | Human | Thyroid | ATC | 1.83e-06 | 4.00e-01 | 0.2878 |
80097 | MZT2B | ATC2 | Human | Thyroid | ATC | 1.10e-32 | 4.10e+00 | 0.34 |
80097 | MZT2B | ATC3 | Human | Thyroid | ATC | 3.61e-15 | 1.84e+00 | 0.338 |
80097 | MZT2B | ATC4 | Human | Thyroid | ATC | 3.28e-56 | 1.49e+00 | 0.34 |
80097 | MZT2B | ATC5 | Human | Thyroid | ATC | 5.23e-56 | 1.95e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MZT2B | SNV | Missense_Mutation | rs773776345 | c.550N>T | p.Arg184Cys | p.R184C | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MZT2B | insertion | Frame_Shift_Ins | rs772879277 | c.614_615insG | p.Gly208ArgfsTer34 | p.G208Rfs*34 | protein_coding | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
MZT2B | insertion | Frame_Shift_Ins | novel | c.29_30insG | p.Ser12ValfsTer106 | p.S12Vfs*106 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
MZT2B | SNV | Missense_Mutation | rs773776345 | c.550N>T | p.Arg184Cys | p.R184C | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
MZT2B | SNV | Missense_Mutation | novel | c.466N>T | p.Arg156Cys | p.R156C | protein_coding | tolerated(0.13) | possibly_damaging(0.685) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
MZT2B | SNV | Missense_Mutation | novel | c.275N>A | p.Pro92His | p.P92H | protein_coding | deleterious(0.01) | probably_damaging(0.937) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MZT2B | SNV | Missense_Mutation | rs1043073 | c.560N>A | p.Arg187His | p.R187H | protein_coding | deleterious(0.01) | possibly_damaging(0.86) | TCGA-BS-A0V4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MZT2B | SNV | Missense_Mutation | novel | c.427N>G | p.Thr143Ala | p.T143A | protein_coding | tolerated(0.58) | benign(0.224) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
MZT2B | insertion | Frame_Shift_Ins | rs772879277 | c.614_615insG | p.Gly208ArgfsTer34 | p.G208Rfs*34 | protein_coding | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
MZT2B | insertion | Frame_Shift_Ins | novel | c.455_456insT | p.Ser154PhefsTer88 | p.S154Ffs*88 | protein_coding | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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