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Gene: LDHB |
Gene summary for LDHB |
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Gene information | Species | Human | Gene symbol | LDHB | Gene ID | 3945 |
Gene name | lactate dehydrogenase B | |
Gene Alias | HEL-S-281 | |
Cytomap | 12p12.1 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | P07195 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3945 | LDHB | Pat12-B | Human | Stomach | GC | 7.45e-31 | -1.98e-01 | 0.0325 |
3945 | LDHB | Pat13-B | Human | Stomach | GC | 5.81e-12 | -5.58e-01 | 0.0555 |
3945 | LDHB | Pat15-B | Human | Stomach | GC | 4.52e-25 | -4.60e-01 | -0.0778 |
3945 | LDHB | Pat16-B | Human | Stomach | GC | 1.91e-16 | -5.56e-01 | 0.1918 |
3945 | LDHB | Pat17-B | Human | Stomach | GC | 1.65e-03 | -4.31e-01 | 0.3109 |
3945 | LDHB | Pat18-B | Human | Stomach | GC | 4.22e-33 | -6.98e-01 | -0.0432 |
3945 | LDHB | Pat19-B | Human | Stomach | GC | 2.06e-20 | -7.42e-01 | 0.0826 |
3945 | LDHB | Pat22-B | Human | Stomach | GC | 2.52e-44 | -6.95e-01 | -0.1042 |
3945 | LDHB | Pat24-B | Human | Stomach | GC | 1.77e-21 | -5.98e-01 | -0.1184 |
3945 | LDHB | Pat25-A | Human | Stomach | CAG with IM | 1.90e-57 | -4.77e-01 | -0.1648 |
3945 | LDHB | Pat26-A | Human | Stomach | CSG | 8.81e-62 | -5.71e-01 | -0.2402 |
3945 | LDHB | Pat28-A | Human | Stomach | CSG | 1.17e-30 | -2.17e-01 | -0.2594 |
3945 | LDHB | Pat29-A | Human | Stomach | CAG with IM | 1.03e-17 | -3.76e-01 | -0.2769 |
3945 | LDHB | NAG_1 | Human | Stomach | CSG | 1.81e-21 | -9.95e-01 | -0.3534 |
3945 | LDHB | NAG_2 | Human | Stomach | CSG | 1.72e-20 | -9.90e-01 | -0.3324 |
3945 | LDHB | NAG_3 | Human | Stomach | CSG | 3.31e-13 | -9.52e-01 | -0.2816 |
3945 | LDHB | CAG_1 | Human | Stomach | CAG | 8.97e-05 | -8.40e-01 | -0.3206 |
3945 | LDHB | CAG_2 | Human | Stomach | CAG | 1.01e-19 | -7.46e-01 | -0.2831 |
3945 | LDHB | CAG_3 | Human | Stomach | CAG | 6.94e-30 | -1.04e+00 | -0.2766 |
3945 | LDHB | WIM_1 | Human | Stomach | WIM | 1.35e-13 | -7.99e-01 | 0.0335 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0406616 | Breast | Precancer | HIF-1 signaling pathway | 23/684 | 109/8465 | 1.51e-05 | 1.59e-04 | 1.22e-04 | 23 |
hsa052309 | Breast | Precancer | Central carbon metabolism in cancer | 13/684 | 70/8465 | 3.57e-03 | 2.17e-02 | 1.66e-02 | 13 |
hsa0406617 | Breast | Precancer | HIF-1 signaling pathway | 23/684 | 109/8465 | 1.51e-05 | 1.59e-04 | 1.22e-04 | 23 |
hsa0523012 | Breast | Precancer | Central carbon metabolism in cancer | 13/684 | 70/8465 | 3.57e-03 | 2.17e-02 | 1.66e-02 | 13 |
hsa0406623 | Breast | IDC | HIF-1 signaling pathway | 22/867 | 109/8465 | 1.36e-03 | 1.00e-02 | 7.50e-03 | 22 |
hsa0406633 | Breast | IDC | HIF-1 signaling pathway | 22/867 | 109/8465 | 1.36e-03 | 1.00e-02 | 7.50e-03 | 22 |
hsa0406642 | Breast | DCIS | HIF-1 signaling pathway | 22/846 | 109/8465 | 9.83e-04 | 7.05e-03 | 5.20e-03 | 22 |
hsa0406652 | Breast | DCIS | HIF-1 signaling pathway | 22/846 | 109/8465 | 9.83e-04 | 7.05e-03 | 5.20e-03 | 22 |
hsa0406618 | Cervix | CC | HIF-1 signaling pathway | 27/1267 | 109/8465 | 4.72e-03 | 1.64e-02 | 9.72e-03 | 27 |
hsa0523010 | Cervix | CC | Central carbon metabolism in cancer | 18/1267 | 70/8465 | 1.29e-02 | 3.87e-02 | 2.29e-02 | 18 |
hsa0406619 | Cervix | CC | HIF-1 signaling pathway | 27/1267 | 109/8465 | 4.72e-03 | 1.64e-02 | 9.72e-03 | 27 |
hsa0523013 | Cervix | CC | Central carbon metabolism in cancer | 18/1267 | 70/8465 | 1.29e-02 | 3.87e-02 | 2.29e-02 | 18 |
hsa00620 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa05230 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa00640 | Colorectum | AD | Propanoate metabolism | 18/2092 | 32/8465 | 1.33e-04 | 1.11e-03 | 7.08e-04 | 18 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa006201 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LDHB | SNV | Missense_Mutation | novel | c.750N>A | p.Asn250Lys | p.N250K | P07195 | protein_coding | deleterious(0.04) | probably_damaging(0.955) | TCGA-OL-A66P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
LDHB | SNV | Missense_Mutation | c.425N>G | p.Asp142Gly | p.D142G | P07195 | protein_coding | deleterious(0.04) | probably_damaging(0.995) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
LDHB | SNV | Missense_Mutation | novel | c.182N>A | p.Gly61Glu | p.G61E | P07195 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LDHB | SNV | Missense_Mutation | novel | c.610N>T | p.Gly204Cys | p.G204C | P07195 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LDHB | SNV | Missense_Mutation | rs200163319 | c.473G>A | p.Arg158His | p.R158H | P07195 | protein_coding | tolerated(0.12) | benign(0.318) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LDHB | SNV | Missense_Mutation | novel | c.503N>A | p.Ser168Tyr | p.S168Y | P07195 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LDHB | SNV | Missense_Mutation | c.832G>T | p.Val278Leu | p.V278L | P07195 | protein_coding | tolerated(0.08) | benign(0.175) | TCGA-G5-6233-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
LDHB | insertion | Frame_Shift_Ins | novel | c.833dupT | p.Met281AspfsTer5 | p.M281Dfs*5 | P07195 | protein_coding | TCGA-G5-6233-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | ||
LDHB | SNV | Missense_Mutation | c.104N>T | p.Ala35Val | p.A35V | P07195 | protein_coding | deleterious(0.04) | possibly_damaging(0.461) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
LDHB | SNV | Missense_Mutation | rs532712842 | c.472C>T | p.Arg158Cys | p.R158C | P07195 | protein_coding | tolerated(0.08) | possibly_damaging(0.51) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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