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Gene: SERP1 |
Gene summary for SERP1 |
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Gene information | Species | Human | Gene symbol | SERP1 | Gene ID | 27230 |
Gene name | stress associated endoplasmic reticulum protein 1 | |
Gene Alias | RAMP4 | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q9Y6X1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27230 | SERP1 | cSCC_p1 | Human | Skin | cSCC | 8.60e-03 | -1.45e-01 | -0.1916 |
27230 | SERP1 | cSCC_p11 | Human | Skin | cSCC | 5.59e-03 | -1.83e-01 | -0.2102 |
27230 | SERP1 | cSCC_p4 | Human | Skin | cSCC | 1.32e-10 | -1.69e-01 | -0.2022 |
27230 | SERP1 | cSCC_p7 | Human | Skin | cSCC | 4.85e-07 | -3.76e-01 | -0.2332 |
27230 | SERP1 | cSCC_p8 | Human | Skin | cSCC | 5.67e-12 | -1.58e-01 | -0.1971 |
27230 | SERP1 | cSCC_p9 | Human | Skin | cSCC | 1.18e-11 | -2.35e-01 | -0.1991 |
27230 | SERP1 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 1.58e-03 | -1.95e-01 | 0.02 |
27230 | SERP1 | PTCwithHT_6 | Human | Thyroid | HT | 1.57e-03 | -3.05e-01 | 0.02 |
27230 | SERP1 | PTCwithHT_8 | Human | Thyroid | HT | 2.58e-06 | -4.49e-01 | 0.0351 |
27230 | SERP1 | PTCwithoutHT_2 | Human | Thyroid | PTC | 1.92e-05 | -4.64e-01 | 0.0419 |
27230 | SERP1 | male-WTA | Human | Thyroid | PTC | 1.70e-64 | 1.13e-01 | 0.1037 |
27230 | SERP1 | PTC01 | Human | Thyroid | PTC | 1.07e-10 | 5.23e-01 | 0.1899 |
27230 | SERP1 | PTC05 | Human | Thyroid | PTC | 9.02e-21 | 1.36e+00 | 0.2065 |
27230 | SERP1 | PTC06 | Human | Thyroid | PTC | 3.95e-33 | 1.11e+00 | 0.2057 |
27230 | SERP1 | PTC07 | Human | Thyroid | PTC | 1.81e-49 | 1.16e+00 | 0.2044 |
27230 | SERP1 | ATC08 | Human | Thyroid | ATC | 3.10e-08 | -2.17e-01 | 0.0541 |
27230 | SERP1 | ATC09 | Human | Thyroid | ATC | 1.36e-09 | 5.00e-01 | 0.2871 |
27230 | SERP1 | ATC12 | Human | Thyroid | ATC | 1.44e-05 | 3.20e-01 | 0.34 |
27230 | SERP1 | ATC13 | Human | Thyroid | ATC | 2.04e-19 | 8.41e-01 | 0.34 |
27230 | SERP1 | ATC1 | Human | Thyroid | ATC | 2.72e-08 | 6.13e-01 | 0.2878 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064179 | Breast | Precancer | regulation of translation | 67/1080 | 468/18723 | 4.71e-12 | 7.64e-10 | 67 |
GO:00457279 | Breast | Precancer | positive regulation of translation | 32/1080 | 136/18723 | 5.89e-12 | 9.27e-10 | 32 |
GO:00342509 | Breast | Precancer | positive regulation of cellular amide metabolic process | 33/1080 | 162/18723 | 1.72e-10 | 1.77e-08 | 33 |
GO:00069869 | Breast | Precancer | response to unfolded protein | 28/1080 | 137/18723 | 3.81e-09 | 3.00e-07 | 28 |
GO:00359669 | Breast | Precancer | response to topologically incorrect protein | 29/1080 | 159/18723 | 3.00e-08 | 1.89e-06 | 29 |
GO:00349769 | Breast | Precancer | response to endoplasmic reticulum stress | 38/1080 | 256/18723 | 7.89e-08 | 4.60e-06 | 38 |
GO:00346209 | Breast | Precancer | cellular response to unfolded protein | 21/1080 | 96/18723 | 9.80e-08 | 5.46e-06 | 21 |
GO:00359679 | Breast | Precancer | cellular response to topologically incorrect protein | 22/1080 | 116/18723 | 6.84e-07 | 2.80e-05 | 22 |
GO:00075688 | Breast | Precancer | aging | 41/1080 | 339/18723 | 5.95e-06 | 1.71e-04 | 41 |
GO:00309687 | Breast | Precancer | endoplasmic reticulum unfolded protein response | 15/1080 | 74/18723 | 1.74e-05 | 4.17e-04 | 15 |
GO:19049519 | Breast | Precancer | positive regulation of establishment of protein localization | 36/1080 | 319/18723 | 9.30e-05 | 1.75e-03 | 36 |
GO:00060066 | Breast | Precancer | glucose metabolic process | 23/1080 | 196/18723 | 9.54e-04 | 1.07e-02 | 23 |
GO:00512229 | Breast | Precancer | positive regulation of protein transport | 31/1080 | 303/18723 | 1.44e-03 | 1.50e-02 | 31 |
GO:00507086 | Breast | Precancer | regulation of protein secretion | 28/1080 | 268/18723 | 1.76e-03 | 1.74e-02 | 28 |
GO:00059966 | Breast | Precancer | monosaccharide metabolic process | 27/1080 | 257/18723 | 1.94e-03 | 1.88e-02 | 27 |
GO:00193186 | Breast | Precancer | hexose metabolic process | 25/1080 | 237/18723 | 2.64e-03 | 2.36e-02 | 25 |
GO:00158336 | Breast | Precancer | peptide transport | 27/1080 | 264/18723 | 2.84e-03 | 2.49e-02 | 27 |
GO:00900875 | Breast | Precancer | regulation of peptide transport | 22/1080 | 202/18723 | 3.14e-03 | 2.65e-02 | 22 |
GO:00300736 | Breast | Precancer | insulin secretion | 21/1080 | 195/18723 | 4.38e-03 | 3.42e-02 | 21 |
GO:00716926 | Breast | Precancer | protein localization to extracellular region | 34/1080 | 368/18723 | 4.65e-03 | 3.58e-02 | 34 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SERP1 | SNV | Missense_Mutation | c.194N>T | p.Gly65Val | p.G65V | Q9Y6X1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SERP1 | SNV | Missense_Mutation | c.86G>T | p.Arg29Ile | p.R29I | Q9Y6X1 | protein_coding | deleterious(0.03) | benign(0.017) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SERP1 | SNV | Missense_Mutation | novel | c.130N>A | p.Ala44Thr | p.A44T | Q9Y6X1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SERP1 | SNV | Missense_Mutation | novel | c.50N>G | p.Asn17Ser | p.N17S | Q9Y6X1 | protein_coding | deleterious(0.03) | possibly_damaging(0.484) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
SERP1 | SNV | Missense_Mutation | novel | c.143N>C | p.Phe48Ser | p.F48S | Q9Y6X1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SERP1 | SNV | Missense_Mutation | novel | c.163N>G | p.Ile55Val | p.I55V | Q9Y6X1 | protein_coding | tolerated(0.54) | benign(0.011) | TCGA-DD-AAE7-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SERP1 | SNV | Missense_Mutation | c.39G>T | p.Lys13Asn | p.K13N | Q9Y6X1 | protein_coding | deleterious(0.01) | probably_damaging(0.911) | TCGA-85-6560-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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