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Gene: PRRC2C |
Gene summary for PRRC2C |
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Gene information | Species | Human | Gene symbol | PRRC2C | Gene ID | 23215 |
Gene name | proline rich coiled-coil 2C | |
Gene Alias | BAT2-iso | |
Cytomap | 1q24.3 | |
Gene Type | protein-coding | GO ID | GO:0002244 | UniProtAcc | Q9Y520 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23215 | PRRC2C | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.18e-36 | 5.23e-01 | 0.1569 |
23215 | PRRC2C | GSM5353247_PA_PR5269_3_S27_L002 | Human | Prostate | Tumor | 9.50e-12 | 6.41e-01 | 0.1532 |
23215 | PRRC2C | GSM5353248_PA_PR5269_4_S28_L002 | Human | Prostate | Tumor | 4.03e-11 | 3.23e-01 | 0.1541 |
23215 | PRRC2C | P1_S1_AK | Human | Skin | AK | 5.67e-18 | 6.28e-01 | -0.3399 |
23215 | PRRC2C | P2_S3_AK | Human | Skin | AK | 1.20e-05 | 4.13e-01 | -0.3287 |
23215 | PRRC2C | P2_S4_SCCIS | Human | Skin | SCCIS | 1.90e-04 | 3.66e-01 | -0.3043 |
23215 | PRRC2C | P3_S6_AK | Human | Skin | AK | 1.55e-09 | 4.08e-01 | -0.3256 |
23215 | PRRC2C | P4_S8_cSCC | Human | Skin | cSCC | 8.94e-23 | 5.10e-01 | -0.3095 |
23215 | PRRC2C | P5_S10_cSCC | Human | Skin | cSCC | 3.92e-14 | 4.60e-01 | -0.299 |
23215 | PRRC2C | P1_cSCC | Human | Skin | cSCC | 1.25e-54 | 1.83e+00 | 0.0292 |
23215 | PRRC2C | P2_cSCC | Human | Skin | cSCC | 1.03e-45 | 1.14e+00 | -0.024 |
23215 | PRRC2C | P4_cSCC | Human | Skin | cSCC | 2.88e-40 | 1.19e+00 | -0.00290000000000005 |
23215 | PRRC2C | P10_cSCC | Human | Skin | cSCC | 5.89e-51 | 1.74e+00 | 0.1017 |
23215 | PRRC2C | cSCC_p8 | Human | Skin | cSCC | 7.88e-08 | 2.66e-01 | -0.1971 |
23215 | PRRC2C | cSCC_p9 | Human | Skin | cSCC | 2.21e-03 | 1.40e-01 | -0.1991 |
23215 | PRRC2C | Pat01-B | Human | Stomach | GC | 2.86e-11 | 3.13e-01 | 0.5754 |
23215 | PRRC2C | Pat02-B | Human | Stomach | GC | 2.64e-38 | 3.56e-01 | 0.0368 |
23215 | PRRC2C | Pat03-B | Human | Stomach | GC | 2.11e-15 | 2.03e-01 | 0.3693 |
23215 | PRRC2C | Pat04-B | Human | Stomach | GC | 5.01e-14 | 1.75e-01 | -0.1483 |
23215 | PRRC2C | Pat05-B | Human | Stomach | GC | 1.38e-10 | 2.45e-01 | -0.0353 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00340635 | Breast | Precancer | stress granule assembly | 6/1080 | 26/18723 | 3.09e-03 | 2.62e-02 | 6 |
GO:00022443 | Cervix | CC | hematopoietic progenitor cell differentiation | 26/2311 | 114/18723 | 1.30e-03 | 1.03e-02 | 26 |
GO:00022441 | Colorectum | FAP | hematopoietic progenitor cell differentiation | 29/2622 | 114/18723 | 8.35e-04 | 8.71e-03 | 29 |
GO:0034063 | Colorectum | FAP | stress granule assembly | 10/2622 | 26/18723 | 1.77e-03 | 1.53e-02 | 10 |
GO:00022442 | Colorectum | CRC | hematopoietic progenitor cell differentiation | 23/2078 | 114/18723 | 3.20e-03 | 2.79e-02 | 23 |
GO:00340631 | Colorectum | CRC | stress granule assembly | 8/2078 | 26/18723 | 5.65e-03 | 4.24e-02 | 8 |
GO:00340638 | Esophagus | HGIN | stress granule assembly | 10/2587 | 26/18723 | 1.60e-03 | 1.79e-02 | 10 |
GO:003406315 | Esophagus | ESCC | stress granule assembly | 23/8552 | 26/18723 | 6.82e-06 | 6.90e-05 | 23 |
GO:00022446 | Esophagus | ESCC | hematopoietic progenitor cell differentiation | 66/8552 | 114/18723 | 5.74e-03 | 2.13e-02 | 66 |
GO:003406311 | Liver | Cirrhotic | stress granule assembly | 18/4634 | 26/18723 | 2.21e-06 | 4.10e-05 | 18 |
GO:00340632 | Liver | HCC | stress granule assembly | 24/7958 | 26/18723 | 1.35e-07 | 2.57e-06 | 24 |
GO:00340634 | Lung | IAC | stress granule assembly | 8/2061 | 26/18723 | 5.38e-03 | 4.03e-02 | 8 |
GO:003406312 | Lung | AIS | stress granule assembly | 8/1849 | 26/18723 | 2.74e-03 | 2.75e-02 | 8 |
GO:003406321 | Lung | MIAC | stress granule assembly | 7/967 | 26/18723 | 2.66e-04 | 8.61e-03 | 7 |
GO:00340637 | Oral cavity | OSCC | stress granule assembly | 21/7305 | 26/18723 | 1.66e-05 | 1.64e-04 | 21 |
GO:00022445 | Oral cavity | OSCC | hematopoietic progenitor cell differentiation | 57/7305 | 114/18723 | 1.09e-02 | 3.71e-02 | 57 |
GO:003406314 | Oral cavity | LP | stress granule assembly | 14/4623 | 26/18723 | 1.33e-03 | 1.07e-02 | 14 |
GO:003406322 | Oral cavity | EOLP | stress granule assembly | 11/2218 | 26/18723 | 8.86e-05 | 1.04e-03 | 11 |
GO:003406331 | Oral cavity | NEOLP | stress granule assembly | 11/2005 | 26/18723 | 3.46e-05 | 5.12e-04 | 11 |
GO:000224412 | Oral cavity | NEOLP | hematopoietic progenitor cell differentiation | 24/2005 | 114/18723 | 8.82e-04 | 6.94e-03 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRRC2C | SNV | Missense_Mutation | novel | c.158G>A | p.Arg53His | p.R53H | Q9Y520 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-A8-A0A9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
PRRC2C | SNV | Missense_Mutation | rs148915470 | c.1346G>A | p.Arg449Gln | p.R449Q | Q9Y520 | protein_coding | tolerated(0.12) | probably_damaging(0.997) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PRRC2C | SNV | Missense_Mutation | c.1468G>A | p.Glu490Lys | p.E490K | Q9Y520 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PRRC2C | SNV | Missense_Mutation | c.3196C>G | p.Gln1066Glu | p.Q1066E | Q9Y520 | protein_coding | tolerated_low_confidence(0.52) | benign(0.092) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PRRC2C | SNV | Missense_Mutation | rs778086980 | c.3118G>A | p.Glu1040Lys | p.E1040K | Q9Y520 | protein_coding | tolerated(0.11) | benign(0.024) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRRC2C | SNV | Missense_Mutation | rs141606555 | c.4661N>A | p.Arg1554Gln | p.R1554Q | Q9Y520 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRRC2C | SNV | Missense_Mutation | c.3634N>G | p.Arg1212Gly | p.R1212G | Q9Y520 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PRRC2C | SNV | Missense_Mutation | rs769715490 | c.6461N>T | p.Thr2154Met | p.T2154M | Q9Y520 | protein_coding | deleterious(0.04) | possibly_damaging(0.534) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PRRC2C | SNV | Missense_Mutation | c.3634N>G | p.Arg1212Gly | p.R1212G | Q9Y520 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | |
PRRC2C | SNV | Missense_Mutation | novel | c.5146G>A | p.Glu1716Lys | p.E1716K | Q9Y520 | protein_coding | tolerated(0.12) | possibly_damaging(0.511) | TCGA-AR-A5QN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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