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Gene: PPP1R14B |
Gene summary for PPP1R14B |
Gene summary. |
Gene information | Species | Human | Gene symbol | PPP1R14B | Gene ID | 26472 |
Gene name | protein phosphatase 1 regulatory inhibitor subunit 14B | |
Gene Alias | PHI-1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q96C90 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26472 | PPP1R14B | ATC09 | Human | Thyroid | ATC | 5.54e-12 | 5.17e-01 | 0.2871 |
26472 | PPP1R14B | ATC11 | Human | Thyroid | ATC | 6.30e-11 | 1.05e+00 | 0.3386 |
26472 | PPP1R14B | ATC12 | Human | Thyroid | ATC | 1.75e-48 | 1.27e+00 | 0.34 |
26472 | PPP1R14B | ATC13 | Human | Thyroid | ATC | 1.68e-53 | 1.47e+00 | 0.34 |
26472 | PPP1R14B | ATC1 | Human | Thyroid | ATC | 1.21e-10 | 6.65e-01 | 0.2878 |
26472 | PPP1R14B | ATC2 | Human | Thyroid | ATC | 9.25e-34 | 2.82e+00 | 0.34 |
26472 | PPP1R14B | ATC3 | Human | Thyroid | ATC | 1.86e-21 | 1.14e+00 | 0.338 |
26472 | PPP1R14B | ATC4 | Human | Thyroid | ATC | 8.92e-68 | 1.61e+00 | 0.34 |
26472 | PPP1R14B | ATC5 | Human | Thyroid | ATC | 5.24e-64 | 1.57e+00 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP1R14B | SNV | Missense_Mutation | novel | c.435N>C | p.Gln145His | p.Q145H | Q96C90 | protein_coding | deleterious(0.01) | possibly_damaging(0.864) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
PPP1R14B | SNV | Missense_Mutation | c.262N>A | p.Glu88Lys | p.E88K | Q96C90 | protein_coding | deleterious(0.02) | possibly_damaging(0.538) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
PPP1R14B | SNV | Missense_Mutation | novel | c.148N>C | p.Val50Leu | p.V50L | Q96C90 | protein_coding | tolerated(0.7) | benign(0.189) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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