Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: NCOR1

Gene summary for NCOR1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

NCOR1

Gene ID

9611

Gene namenuclear receptor corepressor 1
Gene AliasN-CoR
Cytomap17p12-p11.2
Gene Typeprotein-coding
GO ID

GO:0000122

UniProtAcc

O75376


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
9611NCOR1male-WTAHumanThyroidPTC1.02e-443.32e-010.1037
9611NCOR1PTC01HumanThyroidPTC8.32e-317.73e-010.1899
9611NCOR1PTC03HumanThyroidPTC4.34e-176.53e-010.1784
9611NCOR1PTC04HumanThyroidPTC3.71e-377.36e-010.1927
9611NCOR1PTC05HumanThyroidPTC3.68e-291.32e+000.2065
9611NCOR1PTC06HumanThyroidPTC2.39e-641.63e+000.2057
9611NCOR1PTC07HumanThyroidPTC1.75e-691.29e+000.2044
9611NCOR1ATC09HumanThyroidATC2.59e-145.92e-010.2871
9611NCOR1ATC11HumanThyroidATC2.35e-069.11e-010.3386
9611NCOR1ATC12HumanThyroidATC1.44e-256.59e-010.34
9611NCOR1ATC13HumanThyroidATC1.10e-511.09e+000.34
9611NCOR1ATC1HumanThyroidATC2.08e-157.01e-010.2878
9611NCOR1ATC2HumanThyroidATC9.98e-161.53e+000.34
9611NCOR1ATC3HumanThyroidATC1.94e-136.72e-010.338
9611NCOR1ATC4HumanThyroidATC7.48e-308.33e-010.34
9611NCOR1ATC5HumanThyroidATC1.96e-581.17e+000.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0046034ColorectumADATP metabolic process142/3918277/187232.64e-298.26e-26142
GO:0006091ColorectumADgeneration of precursor metabolites and energy209/3918490/187233.17e-286.61e-25209
GO:0009150ColorectumADpurine ribonucleotide metabolic process142/3918368/187234.29e-151.17e-12142
GO:0006163ColorectumADpurine nucleotide metabolic process149/3918396/187231.08e-142.80e-12149
GO:0072521ColorectumADpurine-containing compound metabolic process153/3918416/187234.34e-141.01e-11153
GO:0009259ColorectumADribonucleotide metabolic process144/3918385/187235.25e-141.13e-11144
GO:0009895ColorectumADnegative regulation of catabolic process124/3918320/187231.66e-133.35e-11124
GO:0019693ColorectumADribose phosphate metabolic process145/3918396/187233.01e-135.71e-11145
GO:0009117ColorectumADnucleotide metabolic process168/3918489/187232.20e-123.36e-10168
GO:0006753ColorectumADnucleoside phosphate metabolic process169/3918497/187234.99e-126.98e-10169
GO:0009135ColorectumADpurine nucleoside diphosphate metabolic process47/3918103/187231.61e-089.22e-0747
GO:0009179ColorectumADpurine ribonucleoside diphosphate metabolic process47/3918103/187231.61e-089.22e-0747
GO:0006090ColorectumADpyruvate metabolic process47/3918106/187234.85e-082.55e-0647
GO:0009185ColorectumADribonucleoside diphosphate metabolic process47/3918106/187234.85e-082.55e-0647
GO:0046031ColorectumADADP metabolic process41/391890/187231.37e-076.42e-0641
GO:0006096ColorectumADglycolytic process38/391881/187231.52e-076.78e-0638
GO:0006757ColorectumADATP generation from ADP38/391882/187232.26e-079.37e-0638
GO:0071383ColorectumADcellular response to steroid hormone stimulus73/3918204/187236.31e-072.24e-0573
GO:0009132ColorectumADnucleoside diphosphate metabolic process49/3918124/187231.75e-065.31e-0549
GO:0046939ColorectumADnucleotide phosphorylation42/3918101/187231.99e-065.92e-0542
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04919ColorectumADThyroid hormone signaling pathway51/2092121/84651.71e-051.73e-041.10e-0451
hsa049191ColorectumADThyroid hormone signaling pathway51/2092121/84651.71e-051.73e-041.10e-0451
hsa049192ColorectumSERThyroid hormone signaling pathway40/1580121/84651.02e-041.06e-037.67e-0440
hsa04350ColorectumSERTGF-beta signaling pathway31/1580108/84657.00e-033.77e-022.74e-0231
hsa049193ColorectumSERThyroid hormone signaling pathway40/1580121/84651.02e-041.06e-037.67e-0440
hsa043501ColorectumSERTGF-beta signaling pathway31/1580108/84657.00e-033.77e-022.74e-0231
hsa049194ColorectumMSSThyroid hormone signaling pathway46/1875121/84655.04e-054.97e-043.05e-0446
hsa049195ColorectumMSSThyroid hormone signaling pathway46/1875121/84655.04e-054.97e-043.05e-0446
hsa049196ColorectumMSI-HThyroid hormone signaling pathway21/797121/84654.18e-034.10e-023.44e-0221
hsa049197ColorectumMSI-HThyroid hormone signaling pathway21/797121/84654.18e-034.10e-023.44e-0221
hsa049198ColorectumFAPThyroid hormone signaling pathway41/1404121/84652.28e-064.28e-052.60e-0541
hsa05202ColorectumFAPTranscriptional misregulation in cancer45/1404193/84659.19e-033.33e-022.03e-0245
hsa049199ColorectumFAPThyroid hormone signaling pathway41/1404121/84652.28e-064.28e-052.60e-0541
hsa052021ColorectumFAPTranscriptional misregulation in cancer45/1404193/84659.19e-033.33e-022.03e-0245
hsa0491910ColorectumCRCThyroid hormone signaling pathway35/1091121/84652.05e-066.85e-054.64e-0535
hsa0491911ColorectumCRCThyroid hormone signaling pathway35/1091121/84652.05e-066.85e-054.64e-0535
hsa0491928EsophagusESCCThyroid hormone signaling pathway78/4205121/84656.79e-042.23e-031.14e-0378
hsa043507EsophagusESCCTGF-beta signaling pathway69/4205108/84651.92e-035.54e-032.84e-0369
hsa052028EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa015227EsophagusESCCEndocrine resistance63/420598/84652.38e-036.58e-033.37e-0363
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
NCOR1STMLiverCirrhoticSLC2A9,MARCH6,THOC1, etc.3.10e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
NCOR1STMLiverHCCSLC2A9,MARCH6,THOC1, etc.1.89e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
NCOR1SNVMissense_Mutationnovelc.19C>Tp.Pro7Serp.P7SO75376protein_codingdeleterious(0)possibly_damaging(0.621)TCGA-3C-AALK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydocetaxelSD
NCOR1SNVMissense_Mutationc.1591N>Cp.Glu531Glnp.E531QO75376protein_codingtolerated(0.07)benign(0.042)TCGA-A1-A0SN-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyacSD
NCOR1SNVMissense_Mutationc.3488N>Ap.Gly1163Aspp.G1163DO75376protein_codingdeleterious(0)probably_damaging(0.998)TCGA-A2-A0CU-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
NCOR1SNVMissense_Mutationc.7010N>Tp.Ser2337Phep.S2337FO75376protein_codingdeleterious(0)probably_damaging(0.991)TCGA-A8-A08R-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
NCOR1SNVMissense_Mutationnovelc.2161G>Ap.Glu721Lysp.E721KO75376protein_codingdeleterious(0.02)probably_damaging(0.971)TCGA-AC-A8OP-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
NCOR1SNVMissense_Mutationrs367758096c.451N>Ap.Gly151Serp.G151SO75376protein_codingtolerated(0.18)benign(0.001)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
NCOR1SNVMissense_Mutationc.5725N>Tp.Pro1909Serp.P1909SO75376protein_codingtolerated(0.09)benign(0.162)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
NCOR1SNVMissense_Mutationc.5263N>Tp.Arg1755Cysp.R1755CO75376protein_codingdeleterious(0)probably_damaging(0.925)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
NCOR1SNVMissense_Mutationrs754505756c.4882N>Tp.Arg1628Cysp.R1628CO75376protein_codingdeleterious(0)probably_damaging(0.99)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
NCOR1SNVMissense_Mutationc.3644N>Gp.Lys1215Argp.K1215RO75376protein_codingdeleterious(0.03)probably_damaging(0.985)TCGA-AR-A0TV-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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