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Gene: MYL12B |
Gene summary for MYL12B |
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Gene information | Species | Human | Gene symbol | MYL12B | Gene ID | 103910 |
Gene name | myosin light chain 12B | |
Gene Alias | MLC-B | |
Cytomap | 18p11.31 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O14950 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
103910 | MYL12B | LP16 | Human | Oral cavity | LP | 1.21e-03 | 1.74e+00 | 0.1055 |
103910 | MYL12B | LP17 | Human | Oral cavity | LP | 3.92e-19 | 2.54e+00 | 0.2349 |
103910 | MYL12B | EOLP-1 | Human | Oral cavity | EOLP | 1.82e-05 | -1.12e-01 | -0.0202 |
103910 | MYL12B | EOLP-2 | Human | Oral cavity | EOLP | 4.24e-03 | 1.52e-01 | -0.0203 |
103910 | MYL12B | NEOLP-3 | Human | Oral cavity | NEOLP | 1.02e-05 | -9.26e-02 | -0.0191 |
103910 | MYL12B | SYSMH1 | Human | Oral cavity | OSCC | 4.79e-30 | 1.14e+00 | 0.1127 |
103910 | MYL12B | SYSMH2 | Human | Oral cavity | OSCC | 1.44e-47 | 3.23e+00 | 0.2326 |
103910 | MYL12B | SYSMH3 | Human | Oral cavity | OSCC | 9.30e-55 | 3.42e+00 | 0.2442 |
103910 | MYL12B | SYSMH4 | Human | Oral cavity | OSCC | 1.67e-49 | 1.15e+00 | 0.1226 |
103910 | MYL12B | SYSMH5 | Human | Oral cavity | OSCC | 2.13e-22 | 1.25e+00 | 0.0647 |
103910 | MYL12B | SYSMH6 | Human | Oral cavity | OSCC | 2.34e-46 | 2.16e+00 | 0.1275 |
103910 | MYL12B | GSM5252126_BPH283PrGF_Via | Human | Prostate | BPH | 3.92e-23 | 6.41e-01 | -0.1771 |
103910 | MYL12B | GSM5252127_BPH283PrSF_Via | Human | Prostate | BPH | 1.14e-02 | 3.07e-01 | -0.1453 |
103910 | MYL12B | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 7.74e-10 | 2.45e-01 | -0.1688 |
103910 | MYL12B | GSM5252129_BPH327PrSF_Via | Human | Prostate | BPH | 1.25e-13 | 4.92e-01 | -0.1697 |
103910 | MYL12B | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 1.02e-29 | 1.25e+00 | -0.1972 |
103910 | MYL12B | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 2.94e-30 | 1.02e+00 | -0.2126 |
103910 | MYL12B | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 1.62e-10 | 1.20e+00 | -0.2247 |
103910 | MYL12B | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 4.60e-21 | 1.29e+00 | -0.2027 |
103910 | MYL12B | GSM5252134_BPH511PrG_Fcol_3GEX | Human | Prostate | BPH | 2.44e-14 | 8.74e-01 | -0.1433 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226049 | Breast | Precancer | regulation of cell morphogenesis | 29/1080 | 309/18723 | 6.88e-03 | 4.67e-02 | 29 |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:00083608 | Cervix | CC | regulation of cell shape | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:002260414 | Cervix | HSIL_HPV | regulation of cell morphogenesis | 25/737 | 309/18723 | 5.58e-04 | 7.93e-03 | 25 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0008360 | Colorectum | AD | regulation of cell shape | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:00226041 | Colorectum | SER | regulation of cell morphogenesis | 89/2897 | 309/18723 | 1.51e-09 | 1.52e-07 | 89 |
GO:00083601 | Colorectum | SER | regulation of cell shape | 43/2897 | 154/18723 | 5.47e-05 | 1.30e-03 | 43 |
GO:00226042 | Colorectum | MSS | regulation of cell morphogenesis | 103/3467 | 309/18723 | 2.70e-10 | 2.56e-08 | 103 |
GO:00083602 | Colorectum | MSS | regulation of cell shape | 52/3467 | 154/18723 | 4.40e-06 | 1.24e-04 | 52 |
GO:00226043 | Colorectum | MSI-H | regulation of cell morphogenesis | 45/1319 | 309/18723 | 2.70e-06 | 1.54e-04 | 45 |
GO:00226044 | Colorectum | FAP | regulation of cell morphogenesis | 87/2622 | 309/18723 | 4.89e-11 | 1.87e-08 | 87 |
GO:00083603 | Colorectum | FAP | regulation of cell shape | 43/2622 | 154/18723 | 4.55e-06 | 1.52e-04 | 43 |
GO:00226045 | Colorectum | CRC | regulation of cell morphogenesis | 74/2078 | 309/18723 | 9.25e-11 | 5.04e-08 | 74 |
GO:00083604 | Colorectum | CRC | regulation of cell shape | 38/2078 | 154/18723 | 1.51e-06 | 8.15e-05 | 38 |
GO:002260415 | Endometrium | AEH | regulation of cell morphogenesis | 79/2100 | 309/18723 | 1.04e-12 | 2.24e-10 | 79 |
GO:00083609 | Endometrium | AEH | regulation of cell shape | 34/2100 | 154/18723 | 7.85e-05 | 1.18e-03 | 34 |
GO:002260416 | Endometrium | EEC | regulation of cell morphogenesis | 78/2168 | 309/18723 | 1.45e-11 | 2.28e-09 | 78 |
GO:000836014 | Endometrium | EEC | regulation of cell shape | 34/2168 | 154/18723 | 1.47e-04 | 1.87e-03 | 34 |
GO:002260420 | Esophagus | ESCC | regulation of cell morphogenesis | 180/8552 | 309/18723 | 5.19e-06 | 5.45e-05 | 180 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513118 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0453018 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0467018 | Breast | Precancer | Leukocyte transendothelial migration | 20/684 | 114/8465 | 7.26e-04 | 5.33e-03 | 4.09e-03 | 20 |
hsa0452018 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513119 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0453019 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0467019 | Breast | Precancer | Leukocyte transendothelial migration | 20/684 | 114/8465 | 7.26e-04 | 5.33e-03 | 4.09e-03 | 20 |
hsa0452019 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0453024 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513124 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0467024 | Breast | IDC | Leukocyte transendothelial migration | 21/867 | 114/8465 | 5.41e-03 | 3.13e-02 | 2.34e-02 | 21 |
hsa0481014 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa045109 | Breast | IDC | Focal adhesion | 32/867 | 203/8465 | 8.60e-03 | 4.23e-02 | 3.17e-02 | 32 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0453034 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513134 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0467034 | Breast | IDC | Leukocyte transendothelial migration | 21/867 | 114/8465 | 5.41e-03 | 3.13e-02 | 2.34e-02 | 21 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYL12B | SNV | Missense_Mutation | rs752956376 | c.176N>T | p.Ala59Val | p.A59V | O14950 | protein_coding | tolerated(0.06) | benign(0.018) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYL12B | SNV | Missense_Mutation | c.292N>T | p.Asp98Tyr | p.D98Y | O14950 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MYL12B | SNV | Missense_Mutation | novel | c.21N>T | p.Lys7Asn | p.K7N | O14950 | protein_coding | tolerated(0.06) | possibly_damaging(0.701) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MYL12B | SNV | Missense_Mutation | c.272N>A | p.Gly91Asp | p.G91D | O14950 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYL12B | SNV | Missense_Mutation | novel | c.101T>G | p.Phe34Cys | p.F34C | O14950 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MYL12B | SNV | Missense_Mutation | novel | c.179N>A | p.Ser60Tyr | p.S60Y | O14950 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MYL12B | SNV | Missense_Mutation | c.5C>T | p.Ser2Leu | p.S2L | O14950 | protein_coding | tolerated(0.08) | probably_damaging(0.996) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
MYL12B | SNV | Missense_Mutation | novel | c.386N>T | p.Thr129Ile | p.T129I | O14950 | protein_coding | deleterious(0) | possibly_damaging(0.601) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
MYL12B | SNV | Missense_Mutation | c.472N>A | p.Glu158Lys | p.E158K | O14950 | protein_coding | tolerated(0.2) | benign(0.007) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYL12B | SNV | Missense_Mutation | novel | c.431G>T | p.Arg144Ile | p.R144I | O14950 | protein_coding | deleterious(0.03) | benign(0.197) | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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