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Gene: C19orf53 |
Gene summary for C19ORF53 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C19orf53 | Gene ID | 28974 |
Gene name | chromosome 19 open reading frame 53 | |
Gene Alias | HSPC023 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q9UNZ5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28974 | C19orf53 | Pat07-B | Human | Stomach | GC | 1.12e-08 | 3.41e-01 | 0.0935 |
28974 | C19orf53 | Pat08-B | Human | Stomach | GC | 2.33e-03 | 2.78e-01 | 0.0182 |
28974 | C19orf53 | Pat09-B | Human | Stomach | GC | 8.11e-14 | 3.49e-01 | -0.0359 |
28974 | C19orf53 | Pat10-B | Human | Stomach | GC | 1.41e-03 | 2.77e-01 | 0.084 |
28974 | C19orf53 | Pat11-B | Human | Stomach | GC | 1.59e-25 | 4.82e-01 | -0.182 |
28974 | C19orf53 | Pat12-B | Human | Stomach | GC | 1.62e-33 | 4.34e-01 | 0.0325 |
28974 | C19orf53 | Pat13-B | Human | Stomach | GC | 1.45e-19 | 4.66e-01 | 0.0555 |
28974 | C19orf53 | Pat15-B | Human | Stomach | GC | 9.20e-16 | 2.69e-01 | -0.0778 |
28974 | C19orf53 | Pat16-B | Human | Stomach | GC | 1.27e-18 | 3.52e-01 | 0.1918 |
28974 | C19orf53 | Pat17-B | Human | Stomach | GC | 2.23e-09 | 3.73e-01 | 0.3109 |
28974 | C19orf53 | Pat18-B | Human | Stomach | GC | 8.95e-20 | 1.93e-01 | -0.0432 |
28974 | C19orf53 | Pat19-B | Human | Stomach | GC | 2.27e-13 | 1.85e-01 | 0.0826 |
28974 | C19orf53 | Pat22-B | Human | Stomach | GC | 1.03e-47 | 3.98e-01 | -0.1042 |
28974 | C19orf53 | Pat24-B | Human | Stomach | GC | 9.06e-11 | 2.31e-01 | -0.1184 |
28974 | C19orf53 | Pat25-A | Human | Stomach | CAG with IM | 4.38e-64 | 5.40e-01 | -0.1648 |
28974 | C19orf53 | Pat26-A | Human | Stomach | CSG | 5.44e-66 | 6.14e-01 | -0.2402 |
28974 | C19orf53 | Pat28-A | Human | Stomach | CSG | 2.89e-18 | 3.95e-01 | -0.2594 |
28974 | C19orf53 | Pat29-A | Human | Stomach | CAG with IM | 3.65e-17 | 5.91e-01 | -0.2769 |
28974 | C19orf53 | CAG_3 | Human | Stomach | CAG | 7.73e-09 | 3.43e-01 | -0.2766 |
28974 | C19orf53 | SIM_2 | Human | Stomach | SIM | 2.72e-12 | 3.35e-01 | 0.3139 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C19orf53 | SNV | Missense_Mutation | c.206N>G | p.Ala69Gly | p.A69G | Q9UNZ5 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-A2-A0SU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
C19orf53 | SNV | Missense_Mutation | novel | c.201G>A | p.Met67Ile | p.M67I | Q9UNZ5 | protein_coding | tolerated(0.11) | benign(0.012) | TCGA-ZJ-AAXT-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
C19orf53 | SNV | Missense_Mutation | c.250G>A | p.Ala84Thr | p.A84T | Q9UNZ5 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C19orf53 | SNV | Missense_Mutation | novel | c.4N>A | p.Ala2Thr | p.A2T | Q9UNZ5 | protein_coding | tolerated(0.14) | probably_damaging(0.999) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
C19orf53 | SNV | Missense_Mutation | rs746221045 | c.122C>T | p.Ala41Val | p.A41V | Q9UNZ5 | protein_coding | tolerated(0.1) | possibly_damaging(0.462) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C19orf53 | insertion | Frame_Shift_Ins | novel | c.33_34insA | p.Pro13ThrfsTer5 | p.P13Tfs*5 | Q9UNZ5 | protein_coding | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C19orf53 | SNV | Missense_Mutation | c.49A>G | p.Lys17Glu | p.K17E | Q9UNZ5 | protein_coding | deleterious(0.01) | benign(0.399) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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