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Gene: ATP5J2 |
Gene summary for ATP5J2 |
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Gene information | Species | Human | Gene symbol | ATP5J2 | Gene ID | 9551 |
Gene name | ATP synthase membrane subunit f | |
Gene Alias | ATP5J2 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P56134 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9551 | ATP5J2 | SIM_3 | Human | Stomach | SIM | 3.84e-12 | -5.63e-01 | 0.0345 |
9551 | ATP5J2 | EGC | Human | Stomach | GC | 6.68e-20 | -5.32e-01 | 0.1683 |
9551 | ATP5J2 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 5.27e-05 | -3.84e-01 | 0.02 |
9551 | ATP5J2 | PTCwithHT_8 | Human | Thyroid | HT | 2.00e-03 | -2.78e-01 | 0.0351 |
9551 | ATP5J2 | PTCwithoutHT_2 | Human | Thyroid | PTC | 2.20e-05 | -3.40e-01 | 0.0419 |
9551 | ATP5J2 | male-WTA | Human | Thyroid | PTC | 1.04e-27 | -8.26e-01 | 0.1037 |
9551 | ATP5J2 | female-WTA | Human | Thyroid | PTC | 2.63e-09 | -8.26e-01 | 0.0726 |
9551 | ATP5J2 | nodule-WTA | Human | Thyroid | goiters | 2.68e-20 | -8.26e-01 | 0.0534 |
9551 | ATP5J2 | PTC01 | Human | Thyroid | PTC | 1.50e-26 | -8.26e-01 | 0.1899 |
9551 | ATP5J2 | PTC03 | Human | Thyroid | PTC | 3.84e-07 | -8.26e-01 | 0.1784 |
9551 | ATP5J2 | PTC04 | Human | Thyroid | PTC | 2.11e-25 | -8.26e-01 | 0.1927 |
9551 | ATP5J2 | PTC05 | Human | Thyroid | PTC | 1.85e-07 | -8.26e-01 | 0.2065 |
9551 | ATP5J2 | PTC06 | Human | Thyroid | PTC | 9.05e-16 | -8.26e-01 | 0.2057 |
9551 | ATP5J2 | PTC07 | Human | Thyroid | PTC | 2.34e-18 | -8.26e-01 | 0.2044 |
9551 | ATP5J2 | ATC08 | Human | Thyroid | ATC | 1.03e-06 | -8.26e-01 | 0.0541 |
9551 | ATP5J2 | ATC09 | Human | Thyroid | ATC | 8.95e-08 | -8.26e-01 | 0.2871 |
9551 | ATP5J2 | ATC12 | Human | Thyroid | ATC | 2.11e-25 | -8.26e-01 | 0.34 |
9551 | ATP5J2 | ATC13 | Human | Thyroid | ATC | 1.02e-18 | -8.26e-01 | 0.34 |
9551 | ATP5J2 | ATC1 | Human | Thyroid | ATC | 2.78e-06 | -8.26e-01 | 0.2878 |
9551 | ATP5J2 | ATC3 | Human | Thyroid | ATC | 3.11e-02 | -8.26e-01 | 0.338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0019023 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0471424 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0019033 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0471434 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0019043 | Breast | DCIS | Oxidative phosphorylation | 61/846 | 134/8465 | 9.84e-27 | 5.30e-25 | 3.90e-25 | 61 |
hsa0471443 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0019053 | Breast | DCIS | Oxidative phosphorylation | 61/846 | 134/8465 | 9.84e-27 | 5.30e-25 | 3.90e-25 | 61 |
hsa0471453 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0019018 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa0471420 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa0019019 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa04714110 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa00190 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa001901 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP5J2 | SNV | Missense_Mutation | c.275A>C | p.Lys92Thr | p.K92T | P56134 | protein_coding | deleterious(0) | possibly_damaging(0.649) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ATP5J2 | SNV | Missense_Mutation | rs11545970 | c.128N>T | p.Ala43Val | p.A43V | P56134 | protein_coding | tolerated(0.06) | benign(0.358) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | novel | c.50A>C | p.Lys17Thr | p.K17T | P56134 | protein_coding | deleterious(0.02) | possibly_damaging(0.461) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | rs762526939 | c.265C>T | p.Arg89Trp | p.R89W | P56134 | protein_coding | tolerated(0.06) | benign(0.125) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | novel | c.17N>T | p.Glu6Val | p.E6V | P56134 | protein_coding | tolerated(0.25) | possibly_damaging(0.661) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | novel | c.22N>T | p.Pro8Ser | p.P8S | P56134 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-56-8622-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | rs771516671 | c.149N>A | p.Arg50Gln | p.R50Q | P56134 | protein_coding | tolerated(0.32) | benign(0.015) | TCGA-D7-6520-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | epirubicin | SD |
ATP5J2 | SNV | Missense_Mutation | rs761746638 | c.220N>A | p.Val74Met | p.V74M | P56134 | protein_coding | tolerated(0.15) | benign(0.184) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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