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Gene: ARPC2 |
Gene summary for ARPC2 |
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Gene information | Species | Human | Gene symbol | ARPC2 | Gene ID | 10109 |
Gene name | actin related protein 2/3 complex subunit 2 | |
Gene Alias | ARC34 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O15144 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10109 | ARPC2 | GSM5353247_PA_PR5269_3_S27_L002 | Human | Prostate | Tumor | 3.76e-02 | -8.82e-01 | 0.1532 |
10109 | ARPC2 | GSM5353248_PA_PR5269_4_S28_L002 | Human | Prostate | Tumor | 1.26e-03 | -2.33e-01 | 0.1541 |
10109 | ARPC2 | P1_S1_AK | Human | Skin | AK | 1.85e-02 | 1.17e-02 | -0.3399 |
10109 | ARPC2 | P4_S8_cSCC | Human | Skin | cSCC | 1.73e-08 | 1.59e-01 | -0.3095 |
10109 | ARPC2 | P5_S10_cSCC | Human | Skin | cSCC | 1.80e-09 | 1.45e-01 | -0.299 |
10109 | ARPC2 | P1_cSCC | Human | Skin | cSCC | 4.21e-67 | 3.18e+00 | 0.0292 |
10109 | ARPC2 | P2_cSCC | Human | Skin | cSCC | 4.41e-54 | 2.25e+00 | -0.024 |
10109 | ARPC2 | P4_cSCC | Human | Skin | cSCC | 1.62e-82 | 2.93e+00 | -0.00290000000000005 |
10109 | ARPC2 | P10_cSCC | Human | Skin | cSCC | 3.28e-62 | 3.37e+00 | 0.1017 |
10109 | ARPC2 | cSCC_p1 | Human | Skin | cSCC | 5.27e-16 | 4.18e-01 | -0.1916 |
10109 | ARPC2 | cSCC_p10 | Human | Skin | cSCC | 2.07e-17 | 4.44e-01 | -0.2095 |
10109 | ARPC2 | cSCC_p11 | Human | Skin | cSCC | 4.67e-08 | 2.91e-01 | -0.2102 |
10109 | ARPC2 | cSCC_p4 | Human | Skin | cSCC | 5.53e-03 | 1.12e-01 | -0.2022 |
10109 | ARPC2 | cSCC_p8 | Human | Skin | cSCC | 3.93e-20 | 4.24e-01 | -0.1971 |
10109 | ARPC2 | cSCC_p9 | Human | Skin | cSCC | 2.87e-30 | 4.76e-01 | -0.1991 |
10109 | ARPC2 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 1.62e-13 | 6.54e-01 | 0.02 |
10109 | ARPC2 | PTCwithHT_6 | Human | Thyroid | HT | 4.29e-08 | 5.24e-01 | 0.02 |
10109 | ARPC2 | male-WTA | Human | Thyroid | PTC | 1.13e-60 | 5.30e-01 | 0.1037 |
10109 | ARPC2 | PTC01 | Human | Thyroid | PTC | 8.42e-25 | 8.17e-01 | 0.1899 |
10109 | ARPC2 | PTC03 | Human | Thyroid | PTC | 2.12e-05 | 5.52e-01 | 0.1784 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457859 | Breast | Precancer | positive regulation of cell adhesion | 52/1080 | 437/18723 | 5.74e-07 | 2.49e-05 | 52 |
GO:00432549 | Breast | Precancer | regulation of protein-containing complex assembly | 50/1080 | 428/18723 | 1.63e-06 | 5.97e-05 | 50 |
GO:00313349 | Breast | Precancer | positive regulation of protein-containing complex assembly | 33/1080 | 237/18723 | 2.39e-06 | 8.21e-05 | 33 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00514959 | Breast | Precancer | positive regulation of cytoskeleton organization | 28/1080 | 226/18723 | 1.13e-04 | 2.04e-03 | 28 |
GO:00070159 | Breast | Precancer | actin filament organization | 44/1080 | 442/18723 | 3.02e-04 | 4.35e-03 | 44 |
GO:00329569 | Breast | Precancer | regulation of actin cytoskeleton organization | 36/1080 | 358/18723 | 8.56e-04 | 9.88e-03 | 36 |
GO:00322739 | Breast | Precancer | positive regulation of protein polymerization | 18/1080 | 138/18723 | 9.85e-04 | 1.11e-02 | 18 |
GO:01100539 | Breast | Precancer | regulation of actin filament organization | 29/1080 | 278/18723 | 1.50e-03 | 1.55e-02 | 29 |
GO:19000268 | Breast | Precancer | positive regulation of substrate adhesion-dependent cell spreading | 8/1080 | 41/18723 | 2.08e-03 | 1.97e-02 | 8 |
GO:00108119 | Breast | Precancer | positive regulation of cell-substrate adhesion | 15/1080 | 123/18723 | 4.80e-03 | 3.64e-02 | 15 |
GO:19000248 | Breast | Precancer | regulation of substrate adhesion-dependent cell spreading | 9/1080 | 57/18723 | 5.04e-03 | 3.80e-02 | 9 |
GO:00343146 | Breast | Precancer | Arp2/3 complex-mediated actin nucleation | 7/1080 | 39/18723 | 6.32e-03 | 4.43e-02 | 7 |
GO:00226049 | Breast | Precancer | regulation of cell morphogenesis | 29/1080 | 309/18723 | 6.88e-03 | 4.67e-02 | 29 |
GO:190290514 | Breast | IDC | positive regulation of supramolecular fiber organization | 37/1434 | 209/18723 | 1.33e-06 | 5.75e-05 | 37 |
GO:004578514 | Breast | IDC | positive regulation of cell adhesion | 62/1434 | 437/18723 | 1.70e-06 | 7.16e-05 | 62 |
GO:004325414 | Breast | IDC | regulation of protein-containing complex assembly | 61/1434 | 428/18723 | 1.77e-06 | 7.31e-05 | 61 |
GO:003133414 | Breast | IDC | positive regulation of protein-containing complex assembly | 40/1434 | 237/18723 | 1.77e-06 | 7.31e-05 | 40 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513018 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0513118 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0453018 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0510018 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513019 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0513119 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0453019 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0510019 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0453024 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513024 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513124 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0510024 | Breast | IDC | Bacterial invasion of epithelial cells | 17/867 | 77/8465 | 1.69e-03 | 1.19e-02 | 8.93e-03 | 17 |
hsa0481014 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0453034 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513034 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513134 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARPC2 | SNV | Missense_Mutation | c.442N>A | p.Asp148Asn | p.D148N | O15144 | protein_coding | tolerated(0.08) | benign(0.01) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ARPC2 | SNV | Missense_Mutation | c.836N>A | p.Arg279His | p.R279H | O15144 | protein_coding | deleterious(0.01) | possibly_damaging(0.808) | TCGA-D8-A145-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
ARPC2 | SNV | Missense_Mutation | c.57N>G | p.Phe19Leu | p.F19L | O15144 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-C5-A7CL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
ARPC2 | SNV | Missense_Mutation | c.130N>T | p.His44Tyr | p.H44Y | O15144 | protein_coding | deleterious(0) | benign(0.33) | TCGA-MU-A5YI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ARPC2 | SNV | Missense_Mutation | c.137N>T | p.Ser46Leu | p.S46L | O15144 | protein_coding | deleterious(0) | benign(0.134) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ARPC2 | SNV | Missense_Mutation | c.836N>A | p.Arg279His | p.R279H | O15144 | protein_coding | deleterious(0.01) | possibly_damaging(0.808) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARPC2 | SNV | Missense_Mutation | c.304N>A | p.Leu102Ile | p.L102I | O15144 | protein_coding | tolerated(0.27) | benign(0.013) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ARPC2 | SNV | Missense_Mutation | c.186N>C | p.Lys62Asn | p.K62N | O15144 | protein_coding | tolerated(0.05) | benign(0.421) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ARPC2 | SNV | Missense_Mutation | c.679N>A | p.Leu227Met | p.L227M | O15144 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARPC2 | SNV | Missense_Mutation | c.434N>G | p.His145Arg | p.H145R | O15144 | protein_coding | tolerated(0.08) | benign(0.015) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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