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Gene: ARGLU1 |
Gene summary for ARGLU1 |
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Gene information | Species | Human | Gene symbol | ARGLU1 | Gene ID | 55082 |
Gene name | arginine and glutamate rich 1 | |
Gene Alias | ARGLU1 | |
Cytomap | 13q33.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024RDW4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55082 | ARGLU1 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 8.12e-15 | -5.12e-01 | 0.1569 |
55082 | ARGLU1 | GSM5353247_PA_PR5269_3_S27_L002 | Human | Prostate | Tumor | 4.11e-02 | -7.95e-01 | 0.1532 |
55082 | ARGLU1 | P1_S1_AK | Human | Skin | AK | 9.50e-05 | 3.09e-01 | -0.3399 |
55082 | ARGLU1 | P2_S3_AK | Human | Skin | AK | 5.23e-04 | 2.39e-01 | -0.3287 |
55082 | ARGLU1 | P2_S4_SCCIS | Human | Skin | SCCIS | 2.51e-06 | 3.49e-01 | -0.3043 |
55082 | ARGLU1 | P4_S8_cSCC | Human | Skin | cSCC | 2.65e-11 | 2.61e-01 | -0.3095 |
55082 | ARGLU1 | P5_S10_cSCC | Human | Skin | cSCC | 5.20e-17 | 2.53e-01 | -0.299 |
55082 | ARGLU1 | P1_cSCC | Human | Skin | cSCC | 3.62e-22 | 1.04e+00 | 0.0292 |
55082 | ARGLU1 | P2_cSCC | Human | Skin | cSCC | 6.20e-25 | 8.98e-01 | -0.024 |
55082 | ARGLU1 | P4_cSCC | Human | Skin | cSCC | 8.71e-35 | 9.52e-01 | -0.00290000000000005 |
55082 | ARGLU1 | P10_cSCC | Human | Skin | cSCC | 1.17e-31 | 1.05e+00 | 0.1017 |
55082 | ARGLU1 | cSCC_p4 | Human | Skin | cSCC | 3.84e-03 | -7.64e-02 | -0.2022 |
55082 | ARGLU1 | cSCC_p8 | Human | Skin | cSCC | 4.20e-06 | -4.97e-04 | -0.1971 |
55082 | ARGLU1 | cSCC_p9 | Human | Skin | cSCC | 4.83e-04 | -5.57e-02 | -0.1991 |
55082 | ARGLU1 | Pat01-B | Human | Stomach | GC | 5.35e-16 | 2.47e-01 | 0.5754 |
55082 | ARGLU1 | Pat02-B | Human | Stomach | GC | 1.75e-48 | 3.26e-01 | 0.0368 |
55082 | ARGLU1 | Pat03-B | Human | Stomach | GC | 3.97e-25 | 2.67e-01 | 0.3693 |
55082 | ARGLU1 | Pat04-B | Human | Stomach | GC | 4.29e-26 | 3.43e-01 | -0.1483 |
55082 | ARGLU1 | Pat05-B | Human | Stomach | GC | 1.60e-15 | 2.81e-01 | -0.0353 |
55082 | ARGLU1 | Pat06-B | Human | Stomach | GC | 1.26e-45 | 3.47e-01 | -0.1961 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARGLU1 | SNV | Missense_Mutation | novel | c.736N>A | p.Arg246Ser | p.R246S | Q9NWB6 | protein_coding | deleterious(0) | benign(0.106) | TCGA-AC-A3BB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
ARGLU1 | SNV | Missense_Mutation | novel | c.476N>A | p.Arg159Gln | p.R159Q | Q9NWB6 | protein_coding | deleterious(0.01) | possibly_damaging(0.644) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARGLU1 | SNV | Missense_Mutation | c.289N>A | p.Glu97Lys | p.E97K | Q9NWB6 | protein_coding | deleterious(0.02) | benign(0.117) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ARGLU1 | SNV | Missense_Mutation | novel | c.35N>T | p.Ser12Phe | p.S12F | Q9NWB6 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.983) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARGLU1 | SNV | Missense_Mutation | c.661N>A | p.Glu221Lys | p.E221K | Q9NWB6 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ARGLU1 | SNV | Missense_Mutation | c.473T>A | p.Leu158His | p.L158H | Q9NWB6 | protein_coding | tolerated(0.06) | probably_damaging(0.993) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ARGLU1 | SNV | Missense_Mutation | c.731G>A | p.Arg244Gln | p.R244Q | Q9NWB6 | protein_coding | tolerated(0.75) | probably_damaging(0.947) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ARGLU1 | SNV | Missense_Mutation | c.692N>T | p.Arg231Ile | p.R231I | Q9NWB6 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARGLU1 | SNV | Missense_Mutation | c.734A>C | p.Gln245Pro | p.Q245P | Q9NWB6 | protein_coding | deleterious(0.02) | probably_damaging(0.923) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ARGLU1 | SNV | Missense_Mutation | novel | c.56N>C | p.Lys19Thr | p.K19T | Q9NWB6 | protein_coding | deleterious(0) | possibly_damaging(0.859) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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