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Gene: TMEM141 |
Gene summary for TMEM141 |
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Gene information | Species | Human | Gene symbol | TMEM141 | Gene ID | 85014 |
Gene name | transmembrane protein 141 | |
Gene Alias | TMEM141 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96I45 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85014 | TMEM141 | ATC12 | Human | Thyroid | ATC | 1.14e-07 | 2.52e-01 | 0.34 |
85014 | TMEM141 | ATC13 | Human | Thyroid | ATC | 1.70e-16 | -1.50e-03 | 0.34 |
85014 | TMEM141 | ATC2 | Human | Thyroid | ATC | 9.91e-07 | 4.21e-01 | 0.34 |
85014 | TMEM141 | ATC3 | Human | Thyroid | ATC | 1.58e-02 | 7.95e-02 | 0.338 |
85014 | TMEM141 | ATC4 | Human | Thyroid | ATC | 2.01e-11 | 4.23e-01 | 0.34 |
85014 | TMEM141 | ATC5 | Human | Thyroid | ATC | 2.80e-16 | 2.53e-02 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM141 | SNV | Missense_Mutation | novel | c.182N>G | p.Gln61Arg | p.Q61R | Q96I45 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-AA-3955-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | capecitabine | CR |
TMEM141 | SNV | Missense_Mutation | c.176N>A | p.Pro59His | p.P59H | Q96I45 | protein_coding | deleterious(0.03) | benign(0.292) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM141 | SNV | Missense_Mutation | c.93C>A | p.Phe31Leu | p.F31L | Q96I45 | protein_coding | tolerated(0.3) | probably_damaging(0.971) | TCGA-EY-A1GS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |
TMEM141 | SNV | Missense_Mutation | novel | c.83N>T | p.Ser28Leu | p.S28L | Q96I45 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
TMEM141 | SNV | Missense_Mutation | novel | c.160A>G | p.Arg54Gly | p.R54G | Q96I45 | protein_coding | deleterious(0) | possibly_damaging(0.501) | TCGA-VQ-A91S-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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