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Gene: TMBIM4 |
Gene summary for TMBIM4 |
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Gene information | Species | Human | Gene symbol | TMBIM4 | Gene ID | 51643 |
Gene name | transmembrane BAX inhibitor motif containing 4 | |
Gene Alias | CGI-119 | |
Cytomap | 12q14.3 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | G3XAA5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51643 | TMBIM4 | Pat19-B | Human | Stomach | GC | 1.02e-18 | 2.65e-01 | 0.0826 |
51643 | TMBIM4 | Pat22-B | Human | Stomach | GC | 2.91e-43 | 3.58e-01 | -0.1042 |
51643 | TMBIM4 | Pat24-B | Human | Stomach | GC | 7.07e-14 | 2.16e-01 | -0.1184 |
51643 | TMBIM4 | Pat25-A | Human | Stomach | CAG with IM | 5.22e-59 | 4.54e-01 | -0.1648 |
51643 | TMBIM4 | Pat26-A | Human | Stomach | CSG | 1.05e-65 | 5.13e-01 | -0.2402 |
51643 | TMBIM4 | Pat28-A | Human | Stomach | CSG | 8.72e-27 | 4.50e-01 | -0.2594 |
51643 | TMBIM4 | Pat29-A | Human | Stomach | CAG with IM | 4.59e-17 | 3.47e-01 | -0.2769 |
51643 | TMBIM4 | NAG_1 | Human | Stomach | CSG | 2.25e-10 | -4.93e-01 | -0.3534 |
51643 | TMBIM4 | NAG_2 | Human | Stomach | CSG | 3.58e-09 | -4.93e-01 | -0.3324 |
51643 | TMBIM4 | NAG_3 | Human | Stomach | CSG | 6.08e-06 | -4.93e-01 | -0.2816 |
51643 | TMBIM4 | CAG_1 | Human | Stomach | CAG | 1.40e-02 | -4.93e-01 | -0.3206 |
51643 | TMBIM4 | CAG_2 | Human | Stomach | CAG | 8.72e-11 | -4.93e-01 | -0.2831 |
51643 | TMBIM4 | CAG_3 | Human | Stomach | CAG | 1.29e-12 | -4.93e-01 | -0.2766 |
51643 | TMBIM4 | WIM_1 | Human | Stomach | WIM | 3.58e-09 | -4.93e-01 | 0.0335 |
51643 | TMBIM4 | WIM_2 | Human | Stomach | WIM | 8.17e-06 | -4.93e-01 | 0.1159 |
51643 | TMBIM4 | SIM_1 | Human | Stomach | SIM | 8.72e-11 | -4.93e-01 | 0.3573 |
51643 | TMBIM4 | SIM_2 | Human | Stomach | SIM | 7.63e-13 | -4.93e-01 | 0.3139 |
51643 | TMBIM4 | SIM_3 | Human | Stomach | SIM | 6.05e-10 | -4.93e-01 | 0.0345 |
51643 | TMBIM4 | SIM_4 | Human | Stomach | SIM | 4.94e-14 | -4.93e-01 | 0.2664 |
51643 | TMBIM4 | EGC | Human | Stomach | GC | 1.91e-10 | -4.93e-01 | 0.1683 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00508481 | Breast | DCIS | regulation of calcium-mediated signaling | 12/1390 | 73/18723 | 7.17e-03 | 4.85e-02 | 12 |
GO:0050848 | Liver | Cyst | regulation of calcium-mediated signaling | 8/496 | 73/18723 | 6.81e-04 | 1.88e-02 | 8 |
GO:00508483 | Thyroid | ATC | regulation of calcium-mediated signaling | 36/6293 | 73/18723 | 3.91e-03 | 1.70e-02 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMBIM4 | SNV | Missense_Mutation | c.761N>A | p.Pro254His | p.P254H | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMBIM4 | SNV | Missense_Mutation | rs765685858 | c.691G>A | p.Ala231Thr | p.A231T | protein_coding | tolerated(0.06) | benign(0.065) | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
TMBIM4 | deletion | Frame_Shift_Del | novel | c.30delN | p.Ser11ProfsTer35 | p.S11Pfs*35 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
TMBIM4 | SNV | Missense_Mutation | c.244N>G | p.Leu82Val | p.L82V | protein_coding | deleterious(0.02) | benign(0.421) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | ||
TMBIM4 | SNV | Missense_Mutation | c.25N>T | p.Pro9Ser | p.P9S | protein_coding | tolerated(0.09) | benign(0.341) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
TMBIM4 | SNV | Missense_Mutation | novel | c.706N>T | p.Leu236Phe | p.L236F | protein_coding | deleterious(0.04) | possibly_damaging(0.734) | TCGA-VS-A9V5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
TMBIM4 | SNV | Missense_Mutation | c.458N>C | p.Leu153Pro | p.L153P | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-AA-3667-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TMBIM4 | SNV | Missense_Mutation | c.367T>C | p.Phe123Leu | p.F123L | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-AZ-4308-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Targeted Molecular therapy | avastin | CR | ||
TMBIM4 | SNV | Missense_Mutation | c.469N>G | p.Leu157Val | p.L157V | protein_coding | tolerated(0.18) | benign(0.011) | TCGA-AG-A00H-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | PD | ||
TMBIM4 | SNV | Missense_Mutation | c.711C>A | p.Phe237Leu | p.F237L | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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