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Gene: TBCA |
Gene summary for TBCA |
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Gene information | Species | Human | Gene symbol | TBCA | Gene ID | 6902 |
Gene name | tubulin folding cofactor A | |
Gene Alias | TBCA | |
Cytomap | 5q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | O75347 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6902 | TBCA | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 3.89e-05 | -7.45e-01 | 0.1608 |
6902 | TBCA | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 1.58e-21 | -7.22e-01 | 0.1575 |
6902 | TBCA | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 1.79e-31 | -8.05e-01 | 0.1545 |
6902 | TBCA | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 2.35e-27 | -8.09e-01 | 0.1569 |
6902 | TBCA | GSM5353248_PA_PR5269_4_S28_L002 | Human | Prostate | Tumor | 1.30e-03 | -7.69e-01 | 0.1541 |
6902 | TBCA | P4_S8_cSCC | Human | Skin | cSCC | 1.94e-09 | 1.64e-01 | -0.3095 |
6902 | TBCA | P5_S10_cSCC | Human | Skin | cSCC | 9.77e-11 | 2.46e-01 | -0.299 |
6902 | TBCA | P1_cSCC | Human | Skin | cSCC | 1.58e-55 | 2.12e+00 | 0.0292 |
6902 | TBCA | P2_cSCC | Human | Skin | cSCC | 1.17e-44 | 1.42e+00 | -0.024 |
6902 | TBCA | P4_cSCC | Human | Skin | cSCC | 1.04e-51 | 1.40e+00 | -0.00290000000000005 |
6902 | TBCA | P10_cSCC | Human | Skin | cSCC | 8.12e-54 | 1.65e+00 | 0.1017 |
6902 | TBCA | cSCC_p10 | Human | Skin | cSCC | 4.53e-06 | 3.84e-01 | -0.2095 |
6902 | TBCA | cSCC_p4 | Human | Skin | cSCC | 1.02e-04 | 1.81e-01 | -0.2022 |
6902 | TBCA | cSCC_p7 | Human | Skin | cSCC | 8.39e-06 | 1.78e-01 | -0.2332 |
6902 | TBCA | cSCC_p8 | Human | Skin | cSCC | 2.28e-08 | 2.11e-01 | -0.1971 |
6902 | TBCA | cSCC_p9 | Human | Skin | cSCC | 2.02e-11 | 2.25e-01 | -0.1991 |
6902 | TBCA | Adj_PTCwithHT_6 | Human | Thyroid | HT | 1.32e-06 | -5.05e-01 | 0.02 |
6902 | TBCA | Adj_PTCwithHT_8 | Human | Thyroid | HT | 2.23e-02 | -4.08e-01 | 0.0267 |
6902 | TBCA | PTCwithHT_6 | Human | Thyroid | HT | 4.41e-10 | -5.50e-01 | 0.02 |
6902 | TBCA | male-WTA | Human | Thyroid | PTC | 1.51e-61 | 9.39e-02 | 0.1037 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064578 | Breast | Precancer | protein folding | 43/1080 | 212/18723 | 3.48e-13 | 7.45e-11 | 43 |
GO:000645713 | Breast | IDC | protein folding | 47/1434 | 212/18723 | 2.31e-11 | 3.86e-09 | 47 |
GO:000645723 | Breast | DCIS | protein folding | 47/1390 | 212/18723 | 7.84e-12 | 1.53e-09 | 47 |
GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
GO:00064572 | Colorectum | MSS | protein folding | 71/3467 | 212/18723 | 1.25e-07 | 5.91e-06 | 71 |
GO:00064573 | Colorectum | MSI-H | protein folding | 33/1319 | 212/18723 | 1.40e-05 | 6.29e-04 | 33 |
GO:00064574 | Colorectum | FAP | protein folding | 44/2622 | 212/18723 | 4.36e-03 | 2.98e-02 | 44 |
GO:000645710 | Endometrium | AEH | protein folding | 61/2100 | 212/18723 | 1.86e-12 | 3.48e-10 | 61 |
GO:000645715 | Endometrium | EEC | protein folding | 63/2168 | 212/18723 | 6.82e-13 | 1.40e-10 | 63 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:00064577 | Liver | Cirrhotic | protein folding | 114/4634 | 212/18723 | 9.23e-20 | 2.31e-17 | 114 |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:000645722 | Liver | Cyst | protein folding | 18/496 | 212/18723 | 1.48e-05 | 9.59e-04 | 18 |
GO:000645718 | Oral cavity | OSCC | protein folding | 154/7305 | 212/18723 | 1.89e-23 | 4.60e-21 | 154 |
GO:000645719 | Oral cavity | LP | protein folding | 125/4623 | 212/18723 | 1.62e-26 | 8.45e-24 | 125 |
GO:000645716 | Prostate | BPH | protein folding | 85/3107 | 212/18723 | 2.37e-16 | 4.74e-14 | 85 |
GO:000645717 | Prostate | Tumor | protein folding | 85/3246 | 212/18723 | 3.37e-15 | 5.37e-13 | 85 |
GO:0006457111 | Skin | cSCC | protein folding | 131/4864 | 212/18723 | 2.96e-28 | 1.32e-25 | 131 |
GO:000645727 | Thyroid | HT | protein folding | 45/1272 | 212/18723 | 5.29e-12 | 1.01e-09 | 45 |
GO:0006457112 | Thyroid | PTC | protein folding | 137/5968 | 212/18723 | 8.29e-23 | 2.01e-20 | 137 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBCA | SNV | Missense_Mutation | novel | c.108N>C | p.Lys36Asn | p.K36N | O75347 | protein_coding | deleterious(0.02) | possibly_damaging(0.739) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TBCA | SNV | Missense_Mutation | rs770921213 | c.276A>T | p.Lys92Asn | p.K92N | O75347 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBCA | SNV | Missense_Mutation | novel | c.322T>G | p.Leu108Val | p.L108V | O75347 | protein_coding | deleterious_low_confidence(0.02) | benign(0.018) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TBCA | SNV | Missense_Mutation | c.30G>C | p.Lys10Asn | p.K10N | O75347 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-F5-6864-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
TBCA | deletion | Frame_Shift_Del | novel | c.69delA | p.Val24Ter | p.V24* | O75347 | protein_coding | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
TBCA | deletion | Frame_Shift_Del | novel | c.118delN | p.Met40Ter | p.M40* | O75347 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TBCA | SNV | Missense_Mutation | novel | c.332N>T | p.Arg111Ile | p.R111I | O75347 | protein_coding | deleterious_low_confidence(0) | benign(0.011) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBCA | SNV | Missense_Mutation | novel | c.358A>G | p.Thr120Ala | p.T120A | O75347 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
TBCA | SNV | Missense_Mutation | novel | c.374N>A | p.Arg125His | p.R125H | O75347 | protein_coding | tolerated_low_confidence(0.15) | benign(0) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TBCA | SNV | Missense_Mutation | novel | c.108N>T | p.Lys36Asn | p.K36N | O75347 | protein_coding | deleterious(0.02) | possibly_damaging(0.739) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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