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Gene: PDIA6 |
Gene summary for PDIA6 |
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Gene information | Species | Human | Gene symbol | PDIA6 | Gene ID | 10130 |
Gene name | protein disulfide isomerase family A member 6 | |
Gene Alias | ERP5 | |
Cytomap | 2p25.1 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | Q15084 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10130 | PDIA6 | WIM_1 | Human | Stomach | WIM | 2.35e-06 | -5.50e-01 | 0.0335 |
10130 | PDIA6 | WIM_2 | Human | Stomach | WIM | 1.92e-06 | -7.08e-01 | 0.1159 |
10130 | PDIA6 | SIM_1 | Human | Stomach | SIM | 2.22e-10 | -5.47e-01 | 0.3573 |
10130 | PDIA6 | SIM_2 | Human | Stomach | SIM | 1.30e-19 | -7.03e-01 | 0.3139 |
10130 | PDIA6 | SIM_3 | Human | Stomach | SIM | 3.06e-05 | -2.30e-01 | 0.0345 |
10130 | PDIA6 | SIM_4 | Human | Stomach | SIM | 4.63e-05 | -4.80e-01 | 0.2664 |
10130 | PDIA6 | EGC | Human | Stomach | GC | 2.93e-08 | -3.51e-01 | 0.1683 |
10130 | PDIA6 | Pt1_Superficial | Human | Stomach | GC | 2.76e-02 | -5.53e-01 | 0.1036 |
10130 | PDIA6 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 8.09e-17 | -7.56e-01 | 0.02 |
10130 | PDIA6 | Adj_PTCwithHT_8 | Human | Thyroid | HT | 1.85e-16 | -7.68e-01 | 0.0267 |
10130 | PDIA6 | PTCwithHT_1 | Human | Thyroid | HT | 1.17e-07 | -7.88e-01 | 0.0238 |
10130 | PDIA6 | PTCwithHT_6 | Human | Thyroid | HT | 3.74e-17 | -7.55e-01 | 0.02 |
10130 | PDIA6 | PTCwithHT_8 | Human | Thyroid | HT | 4.19e-18 | -7.75e-01 | 0.0351 |
10130 | PDIA6 | PTCwithoutHT_2 | Human | Thyroid | PTC | 1.02e-18 | -7.65e-01 | 0.0419 |
10130 | PDIA6 | PTCwithoutHT_7 | Human | Thyroid | PTC | 4.11e-05 | -7.45e-01 | 0.0381 |
10130 | PDIA6 | male-WTA | Human | Thyroid | PTC | 6.33e-71 | 2.74e-01 | 0.1037 |
10130 | PDIA6 | nodule-WTA | Human | Thyroid | goiters | 4.40e-02 | 3.02e-01 | 0.0534 |
10130 | PDIA6 | PTC01 | Human | Thyroid | PTC | 1.65e-20 | 9.10e-01 | 0.1899 |
10130 | PDIA6 | PTC04 | Human | Thyroid | PTC | 8.90e-07 | 7.99e-01 | 0.1927 |
10130 | PDIA6 | PTC05 | Human | Thyroid | PTC | 1.31e-21 | 1.55e+00 | 0.2065 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064578 | Breast | Precancer | protein folding | 43/1080 | 212/18723 | 3.48e-13 | 7.45e-11 | 43 |
GO:000645713 | Breast | IDC | protein folding | 47/1434 | 212/18723 | 2.31e-11 | 3.86e-09 | 47 |
GO:000645723 | Breast | DCIS | protein folding | 47/1390 | 212/18723 | 7.84e-12 | 1.53e-09 | 47 |
GO:00064579 | Cervix | CC | protein folding | 44/2311 | 212/18723 | 3.43e-04 | 3.59e-03 | 44 |
GO:000645724 | Cervix | N_HPV | protein folding | 22/534 | 212/18723 | 1.90e-07 | 1.57e-05 | 22 |
GO:000645710 | Endometrium | AEH | protein folding | 61/2100 | 212/18723 | 1.86e-12 | 3.48e-10 | 61 |
GO:000645715 | Endometrium | EEC | protein folding | 63/2168 | 212/18723 | 6.82e-13 | 1.40e-10 | 63 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:00064577 | Liver | Cirrhotic | protein folding | 114/4634 | 212/18723 | 9.23e-20 | 2.31e-17 | 114 |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:000645722 | Liver | Cyst | protein folding | 18/496 | 212/18723 | 1.48e-05 | 9.59e-04 | 18 |
GO:000645718 | Oral cavity | OSCC | protein folding | 154/7305 | 212/18723 | 1.89e-23 | 4.60e-21 | 154 |
GO:000645719 | Oral cavity | LP | protein folding | 125/4623 | 212/18723 | 1.62e-26 | 8.45e-24 | 125 |
GO:000645725 | Oral cavity | EOLP | protein folding | 59/2218 | 212/18723 | 1.76e-10 | 1.79e-08 | 59 |
GO:000645716 | Prostate | BPH | protein folding | 85/3107 | 212/18723 | 2.37e-16 | 4.74e-14 | 85 |
GO:000645717 | Prostate | Tumor | protein folding | 85/3246 | 212/18723 | 3.37e-15 | 5.37e-13 | 85 |
GO:0006457111 | Skin | cSCC | protein folding | 131/4864 | 212/18723 | 2.96e-28 | 1.32e-25 | 131 |
GO:00064576 | Stomach | GC | protein folding | 42/1159 | 212/18723 | 1.46e-11 | 3.31e-09 | 42 |
GO:000645711 | Stomach | CAG with IM | protein folding | 42/1050 | 212/18723 | 5.92e-13 | 2.11e-10 | 42 |
GO:000645721 | Stomach | CSG | protein folding | 42/1034 | 212/18723 | 3.56e-13 | 1.26e-10 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414118 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414119 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414124 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414134 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414143 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414153 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414120 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa04141110 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa0414144 | Cervix | N_HPV | Protein processing in endoplasmic reticulum | 21/349 | 174/8465 | 8.84e-06 | 1.09e-04 | 8.55e-05 | 21 |
hsa0414154 | Cervix | N_HPV | Protein processing in endoplasmic reticulum | 21/349 | 174/8465 | 8.84e-06 | 1.09e-04 | 8.55e-05 | 21 |
hsa0414126 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa04141111 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa0414127 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0414136 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDIA6 | SNV | Missense_Mutation | novel | c.70C>T | p.Arg24Cys | p.R24C | Q15084 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDIA6 | SNV | Missense_Mutation | novel | c.136N>G | p.Pro46Ala | p.P46A | Q15084 | protein_coding | tolerated_low_confidence(0.28) | benign(0) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
PDIA6 | SNV | Missense_Mutation | rs373388851 | c.713A>G | p.Tyr238Cys | p.Y238C | Q15084 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDIA6 | SNV | Missense_Mutation | c.788N>T | p.Thr263Met | p.T263M | Q15084 | protein_coding | tolerated(0.2) | probably_damaging(0.93) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PDIA6 | SNV | Missense_Mutation | novel | c.241G>A | p.Glu81Lys | p.E81K | Q15084 | protein_coding | tolerated(0.1) | benign(0.17) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDIA6 | SNV | Missense_Mutation | c.458T>C | p.Ile153Thr | p.I153T | Q15084 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PDIA6 | SNV | Missense_Mutation | rs775783522 | c.581N>A | p.Arg194Gln | p.R194Q | Q15084 | protein_coding | tolerated(0.06) | benign(0.065) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDIA6 | SNV | Missense_Mutation | c.541N>G | p.Ser181Gly | p.S181G | Q15084 | protein_coding | tolerated(0.2) | benign(0.044) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PDIA6 | SNV | Missense_Mutation | rs138012463 | c.1249C>T | p.Arg417Cys | p.R417C | Q15084 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
PDIA6 | SNV | Missense_Mutation | c.707N>C | p.Glu236Ala | p.E236A | Q15084 | protein_coding | tolerated(0.05) | probably_damaging(0.991) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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