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Gene: NUCKS1 |
Gene summary for NUCKS1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NUCKS1 | Gene ID | 64710 |
| Gene name | nuclear casein kinase and cyclin dependent kinase substrate 1 | |
| Gene Alias | JC7 | |
| Cytomap | 1q32.1 | |
| Gene Type | protein-coding | GO ID | GO:0000724 | UniProtAcc | Q9H1E3 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64710 | NUCKS1 | P7 | Human | Prostate | Tumor | 2.18e-14 | 9.09e-01 | -0.1025 |
| 64710 | NUCKS1 | P10 | Human | Prostate | Tumor | 5.55e-09 | 8.03e-01 | -0.0902 |
| 64710 | NUCKS1 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 2.06e-16 | 7.36e-01 | 0.1557 |
| 64710 | NUCKS1 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 1.22e-05 | 5.37e-01 | 0.159 |
| 64710 | NUCKS1 | GSM5353217_PA_PB1A_Pool_2_S107_L004 | Human | Prostate | Tumor | 1.73e-09 | 7.83e-01 | 0.156 |
| 64710 | NUCKS1 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 6.53e-11 | 5.30e-01 | 0.1633 |
| 64710 | NUCKS1 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 3.28e-18 | 4.95e-01 | 0.1608 |
| 64710 | NUCKS1 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 1.42e-19 | 6.31e-01 | 0.1604 |
| 64710 | NUCKS1 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 4.36e-06 | 4.64e-01 | 0.1621 |
| 64710 | NUCKS1 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 6.14e-04 | 3.38e-01 | 0.1619 |
| 64710 | NUCKS1 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 3.31e-21 | 5.25e-01 | 0.1602 |
| 64710 | NUCKS1 | GSM5353228_PA_PR5199-640K_Pool_1_3_S108_L004 | Human | Prostate | Tumor | 3.80e-03 | -5.48e-02 | 0.1537 |
| 64710 | NUCKS1 | GSM5353232_PA_PR5249_T1_S3_L001 | Human | Prostate | Tumor | 4.15e-11 | 2.17e-01 | 0.1439 |
| 64710 | NUCKS1 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 6.34e-17 | 6.85e-01 | 0.1608 |
| 64710 | NUCKS1 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 1.32e-11 | 6.91e-01 | 0.1622 |
| 64710 | NUCKS1 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 1.25e-18 | 3.47e-01 | 0.1575 |
| 64710 | NUCKS1 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 7.03e-40 | 3.80e-01 | 0.1545 |
| 64710 | NUCKS1 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 3.26e-29 | 5.03e-01 | 0.1569 |
| 64710 | NUCKS1 | GSM5353247_PA_PR5269_3_S27_L002 | Human | Prostate | Tumor | 1.79e-03 | 2.14e-01 | 0.1532 |
| 64710 | NUCKS1 | GSM5353248_PA_PR5269_4_S28_L002 | Human | Prostate | Tumor | 5.25e-16 | 3.69e-01 | 0.1541 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
| GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
| GO:001907914 | Breast | IDC | viral genome replication | 32/1434 | 131/18723 | 2.82e-09 | 2.46e-07 | 32 |
| GO:004440314 | Breast | IDC | biological process involved in symbiotic interaction | 52/1434 | 290/18723 | 6.55e-09 | 5.03e-07 | 52 |
| GO:005109814 | Breast | IDC | regulation of binding | 57/1434 | 363/18723 | 1.59e-07 | 8.76e-06 | 57 |
| GO:007147913 | Breast | IDC | cellular response to ionizing radiation | 18/1434 | 72/18723 | 5.67e-06 | 1.85e-04 | 18 |
| GO:001021213 | Breast | IDC | response to ionizing radiation | 28/1434 | 148/18723 | 6.85e-06 | 2.09e-04 | 28 |
| GO:000931412 | Breast | IDC | response to radiation | 62/1434 | 456/18723 | 6.91e-06 | 2.10e-04 | 62 |
| GO:007121413 | Breast | IDC | cellular response to abiotic stimulus | 48/1434 | 331/18723 | 1.37e-05 | 3.53e-04 | 48 |
| GO:010400413 | Breast | IDC | cellular response to environmental stimulus | 48/1434 | 331/18723 | 1.37e-05 | 3.53e-04 | 48 |
| GO:00434348 | Breast | IDC | response to peptide hormone | 54/1434 | 414/18723 | 8.25e-05 | 1.61e-03 | 54 |
| GO:007147813 | Breast | IDC | cellular response to radiation | 29/1434 | 186/18723 | 1.91e-04 | 3.15e-03 | 29 |
| GO:00517025 | Breast | IDC | biological process involved in interaction with symbiont | 18/1434 | 94/18723 | 2.46e-04 | 3.85e-03 | 18 |
| GO:004259313 | Breast | IDC | glucose homeostasis | 34/1434 | 258/18723 | 1.34e-03 | 1.39e-02 | 34 |
| GO:003350013 | Breast | IDC | carbohydrate homeostasis | 34/1434 | 259/18723 | 1.43e-03 | 1.46e-02 | 34 |
| GO:00447883 | Breast | IDC | modulation by host of viral process | 8/1434 | 30/18723 | 1.48e-03 | 1.50e-02 | 8 |
| GO:00518513 | Breast | IDC | modulation by host of symbiont process | 12/1434 | 60/18723 | 1.73e-03 | 1.69e-02 | 12 |
| GO:00447943 | Breast | IDC | positive regulation by host of viral process | 5/1434 | 13/18723 | 2.00e-03 | 1.90e-02 | 5 |
| GO:00439221 | Breast | IDC | negative regulation by host of viral transcription | 5/1434 | 14/18723 | 2.92e-03 | 2.53e-02 | 5 |
| GO:000167813 | Breast | IDC | cellular glucose homeostasis | 24/1434 | 172/18723 | 3.07e-03 | 2.60e-02 | 24 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| NUCKS1 | SNV | Missense_Mutation | c.256C>T | p.His86Tyr | p.H86Y | Q9H1E3 | protein_coding | tolerated(0.46) | benign(0.091) | TCGA-BH-A0DX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
| NUCKS1 | SNV | Missense_Mutation | rs771629435 | c.635C>T | p.Pro212Leu | p.P212L | Q9H1E3 | protein_coding | tolerated(0.29) | benign(0.061) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
| NUCKS1 | SNV | Missense_Mutation | rs754971187 | c.274N>A | p.Gln92Lys | p.Q92K | Q9H1E3 | protein_coding | tolerated(1) | benign(0.444) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| NUCKS1 | SNV | Missense_Mutation | novel | c.218C>A | p.Ser73Tyr | p.S73Y | Q9H1E3 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| NUCKS1 | SNV | Missense_Mutation | rs762593780 | c.89N>T | p.Ser30Leu | p.S30L | Q9H1E3 | protein_coding | tolerated(0.15) | possibly_damaging(0.572) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| NUCKS1 | SNV | Missense_Mutation | rs551812416 | c.572N>A | p.Arg191His | p.R191H | Q9H1E3 | protein_coding | deleterious(0.05) | benign(0.001) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| NUCKS1 | SNV | Missense_Mutation | novel | c.295N>A | p.Ala99Thr | p.A99T | Q9H1E3 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| NUCKS1 | SNV | Missense_Mutation | c.98N>T | p.Pro33Leu | p.P33L | Q9H1E3 | protein_coding | deleterious(0) | possibly_damaging(0.535) | TCGA-AP-A0LG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| NUCKS1 | SNV | Missense_Mutation | rs758268939 | c.446N>T | p.Ser149Leu | p.S149L | Q9H1E3 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-B5-A0JR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| NUCKS1 | SNV | Missense_Mutation | novel | c.343N>A | p.Glu115Lys | p.E115K | Q9H1E3 | protein_coding | tolerated(0.1) | possibly_damaging(0.452) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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