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Gene: MIF |
Gene summary for MIF |
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Gene information | Species | Human | Gene symbol | MIF | Gene ID | 4282 |
Gene name | macrophage migration inhibitory factor | |
Gene Alias | GIF | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | I4AY87 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4282 | MIF | NEOLP-3 | Human | Oral cavity | NEOLP | 6.82e-05 | 2.12e-01 | -0.0191 |
4282 | MIF | SYSMH1 | Human | Oral cavity | OSCC | 4.04e-33 | 1.45e+00 | 0.1127 |
4282 | MIF | SYSMH3 | Human | Oral cavity | OSCC | 8.13e-40 | 2.35e+00 | 0.2442 |
4282 | MIF | SYSMH4 | Human | Oral cavity | OSCC | 9.87e-05 | -9.26e-02 | 0.1226 |
4282 | MIF | SYSMH5 | Human | Oral cavity | OSCC | 1.77e-18 | 1.12e+00 | 0.0647 |
4282 | MIF | HTA12-26-1 | Human | Pancreas | PDAC | 2.81e-02 | -7.41e-01 | 0.3728 |
4282 | MIF | HTA12-29-1 | Human | Pancreas | PDAC | 3.54e-10 | -6.97e-01 | 0.3722 |
4282 | MIF | 3829-EC | Human | Pancreas | PanIN | 1.03e-08 | -9.15e-02 | 0.009 |
4282 | MIF | 4347-EC | Human | Pancreas | PanIN | 7.90e-16 | -3.00e-03 | 0.0572 |
4282 | MIF | DS20191261Tumor | Human | Pancreas | PDAC | 9.70e-07 | -3.48e-01 | 0.1367 |
4282 | MIF | GSM5252126_BPH283PrGF_Via | Human | Prostate | BPH | 3.84e-32 | 7.27e-01 | -0.1771 |
4282 | MIF | GSM5252127_BPH283PrSF_Via | Human | Prostate | BPH | 3.25e-23 | 5.98e-01 | -0.1453 |
4282 | MIF | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 1.04e-30 | 9.39e-01 | -0.1688 |
4282 | MIF | GSM5252129_BPH327PrSF_Via | Human | Prostate | BPH | 9.29e-41 | 1.04e+00 | -0.1697 |
4282 | MIF | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 2.25e-52 | 1.46e+00 | -0.1972 |
4282 | MIF | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 5.73e-59 | 1.68e+00 | -0.2126 |
4282 | MIF | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 5.83e-12 | 1.30e+00 | -0.2247 |
4282 | MIF | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 9.26e-13 | 1.45e+00 | -0.2027 |
4282 | MIF | GSM5252134_BPH511PrG_Fcol_3GEX | Human | Prostate | BPH | 1.37e-14 | 5.09e-01 | -0.1433 |
4282 | MIF | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 9.80e-20 | 8.34e-01 | -0.1833 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00971939 | Breast | Precancer | intrinsic apoptotic signaling pathway | 59/1080 | 288/18723 | 8.07e-18 | 3.60e-15 | 59 |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:20012429 | Breast | Precancer | regulation of intrinsic apoptotic signaling pathway | 41/1080 | 164/18723 | 6.48e-16 | 2.31e-13 | 41 |
GO:20012349 | Breast | Precancer | negative regulation of apoptotic signaling pathway | 39/1080 | 224/18723 | 5.35e-10 | 4.77e-08 | 39 |
GO:20012439 | Breast | Precancer | negative regulation of intrinsic apoptotic signaling pathway | 23/1080 | 98/18723 | 5.82e-09 | 4.45e-07 | 23 |
GO:00975297 | Breast | Precancer | myeloid leukocyte migration | 34/1080 | 220/18723 | 1.42e-07 | 7.82e-06 | 34 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00305956 | Breast | Precancer | leukocyte chemotaxis | 34/1080 | 230/18723 | 4.16e-07 | 1.89e-05 | 34 |
GO:00603266 | Breast | Precancer | cell chemotaxis | 41/1080 | 310/18723 | 5.99e-07 | 2.55e-05 | 41 |
GO:19017969 | Breast | Precancer | regulation of signal transduction by p53 class mediator | 19/1080 | 93/18723 | 1.20e-06 | 4.60e-05 | 19 |
GO:00723319 | Breast | Precancer | signal transduction by p53 class mediator | 26/1080 | 163/18723 | 2.23e-06 | 7.76e-05 | 26 |
GO:00018196 | Breast | Precancer | positive regulation of cytokine production | 52/1080 | 467/18723 | 4.18e-06 | 1.29e-04 | 52 |
GO:00723328 | Breast | Precancer | intrinsic apoptotic signaling pathway by p53 class mediator | 16/1080 | 76/18723 | 5.49e-06 | 1.63e-04 | 16 |
GO:00075688 | Breast | Precancer | aging | 41/1080 | 339/18723 | 5.95e-06 | 1.71e-04 | 41 |
GO:19022537 | Breast | Precancer | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 9/1080 | 29/18723 | 2.40e-05 | 5.53e-04 | 9 |
GO:00026856 | Breast | Precancer | regulation of leukocyte migration | 27/1080 | 210/18723 | 7.93e-05 | 1.54e-03 | 27 |
GO:00086308 | Breast | Precancer | intrinsic apoptotic signaling pathway in response to DNA damage | 16/1080 | 99/18723 | 1.65e-04 | 2.74e-03 | 16 |
GO:19021655 | Breast | Precancer | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 6/1080 | 16/18723 | 1.76e-04 | 2.87e-03 | 6 |
GO:00482463 | Breast | Precancer | macrophage chemotaxis | 9/1080 | 38/18723 | 2.44e-04 | 3.66e-03 | 9 |
GO:19055173 | Breast | Precancer | macrophage migration | 11/1080 | 55/18723 | 2.57e-04 | 3.83e-03 | 11 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | ADJ |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | ADJ |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | ADJ |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | DCIS |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | DCIS |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | DCIS |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | Healthy |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | Healthy |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | Healthy |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | IDC |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | IDC |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | Precancer |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | Precancer |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | ADJ |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Cervix | ADJ |
MIF | ACKR3 | MIF_ACKR3 | MIF | Cervix | ADJ |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | CC |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Cervix | CC |
MIF | ACKR3 | MIF_ACKR3 | MIF | Cervix | CC |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | Healthy |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MIF | SNV | Missense_Mutation | novel | c.266N>C | p.Arg89Pro | p.R89P | P14174 | protein_coding | tolerated(0.21) | benign(0.219) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MIF | insertion | Frame_Shift_Ins | rs767392036 | c.99_100insC | p.Gln36ProfsTer? | p.Q36Pfs*? | P14174 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MIF | SNV | Missense_Mutation | novel | c.95N>A | p.Gly32Asp | p.G32D | P14174 | protein_coding | tolerated(0.06) | benign(0.136) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MIF | insertion | Frame_Shift_Ins | rs767392036 | c.99_100insC | p.Gln36ProfsTer? | p.Q36Pfs*? | P14174 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MIF | SNV | Missense_Mutation | c.52N>T | p.Gly18Trp | p.G18W | P14174 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | ANTI-MIF MONOCLONAL ANTIBODY | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | COR100140 | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | PPD | 393437 | ||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | Anti-MIF antibodies | 22238348 | ||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | TCMDC-124484 | CHEMBL524449 | 21719283 | |
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | ISO-1 | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | PMA | 3305746 |
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