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Gene: HIGD2A |
Gene summary for HIGD2A |
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Gene information | Species | Human | Gene symbol | HIGD2A | Gene ID | 192286 |
Gene name | HIG1 hypoxia inducible domain family member 2A | |
Gene Alias | RCF1b | |
Cytomap | 5q35.2 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | A0A024R7Q3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
192286 | HIGD2A | Pat11-B | Human | Stomach | GC | 1.65e-18 | 2.96e-01 | -0.182 |
192286 | HIGD2A | Pat12-B | Human | Stomach | GC | 2.40e-30 | 2.58e-01 | 0.0325 |
192286 | HIGD2A | Pat13-B | Human | Stomach | GC | 8.12e-09 | 1.84e-01 | 0.0555 |
192286 | HIGD2A | Pat15-B | Human | Stomach | GC | 6.07e-17 | 1.07e-01 | -0.0778 |
192286 | HIGD2A | Pat16-B | Human | Stomach | GC | 8.13e-07 | 2.88e-02 | 0.1918 |
192286 | HIGD2A | Pat18-B | Human | Stomach | GC | 8.58e-22 | 1.58e-01 | -0.0432 |
192286 | HIGD2A | Pat19-B | Human | Stomach | GC | 4.78e-10 | 8.51e-02 | 0.0826 |
192286 | HIGD2A | Pat22-B | Human | Stomach | GC | 1.67e-50 | 3.90e-01 | -0.1042 |
192286 | HIGD2A | Pat24-B | Human | Stomach | GC | 1.31e-12 | 2.14e-01 | -0.1184 |
192286 | HIGD2A | Pat25-A | Human | Stomach | CAG with IM | 2.70e-52 | 5.00e-01 | -0.1648 |
192286 | HIGD2A | Pat26-A | Human | Stomach | CSG | 7.84e-52 | 5.67e-01 | -0.2402 |
192286 | HIGD2A | Pat28-A | Human | Stomach | CSG | 1.44e-28 | 4.74e-01 | -0.2594 |
192286 | HIGD2A | Pat29-A | Human | Stomach | CAG with IM | 4.34e-20 | 5.93e-01 | -0.2769 |
192286 | HIGD2A | CAG_3 | Human | Stomach | CAG | 1.46e-06 | 2.46e-01 | -0.2766 |
192286 | HIGD2A | SIM_2 | Human | Stomach | SIM | 1.01e-03 | 1.90e-01 | 0.3139 |
192286 | HIGD2A | male-WTA | Human | Thyroid | PTC | 8.26e-36 | 4.67e-02 | 0.1037 |
192286 | HIGD2A | PTC01 | Human | Thyroid | PTC | 1.42e-07 | 1.43e-01 | 0.1899 |
192286 | HIGD2A | PTC04 | Human | Thyroid | PTC | 6.49e-03 | 1.33e-01 | 0.1927 |
192286 | HIGD2A | PTC05 | Human | Thyroid | PTC | 1.65e-19 | 6.24e-01 | 0.2065 |
192286 | HIGD2A | PTC06 | Human | Thyroid | PTC | 3.14e-25 | 7.11e-01 | 0.2057 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097250 | Stomach | GC | mitochondrial respirasome assembly | 4/1159 | 10/18723 | 2.27e-03 | 2.20e-02 | 4 |
GO:00972501 | Stomach | CAG with IM | mitochondrial respirasome assembly | 4/1050 | 10/18723 | 1.57e-03 | 1.75e-02 | 4 |
GO:00972502 | Stomach | CSG | mitochondrial respirasome assembly | 4/1034 | 10/18723 | 1.48e-03 | 1.68e-02 | 4 |
GO:00972503 | Stomach | CAG | mitochondrial respirasome assembly | 3/552 | 10/18723 | 2.62e-03 | 2.71e-02 | 3 |
GO:00972504 | Stomach | SIM | mitochondrial respirasome assembly | 3/708 | 10/18723 | 5.29e-03 | 4.41e-02 | 3 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIGD2A | SNV | Missense_Mutation | novel | c.68G>C | p.Gly23Ala | p.G23A | Q9BW72 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
HIGD2A | SNV | Missense_Mutation | c.226N>G | p.Gln76Glu | p.Q76E | Q9BW72 | protein_coding | deleterious(0) | possibly_damaging(0.685) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HIGD2A | SNV | Missense_Mutation | c.262T>C | p.Phe88Leu | p.F88L | Q9BW72 | protein_coding | tolerated(0.1) | probably_damaging(0.975) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HIGD2A | SNV | Missense_Mutation | c.247A>G | p.Ile83Val | p.I83V | Q9BW72 | protein_coding | tolerated(0.41) | possibly_damaging(0.497) | TCGA-D5-6535-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
HIGD2A | SNV | Missense_Mutation | novel | c.209N>A | p.Gly70Asp | p.G70D | Q9BW72 | protein_coding | tolerated(0.05) | possibly_damaging(0.878) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIGD2A | SNV | Missense_Mutation | c.103T>G | p.Phe35Val | p.F35V | Q9BW72 | protein_coding | tolerated(0.08) | benign(0.189) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
HIGD2A | SNV | Missense_Mutation | novel | c.105N>A | p.Phe35Leu | p.F35L | Q9BW72 | protein_coding | tolerated(0.1) | possibly_damaging(0.526) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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