Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CUTA

Gene summary for CUTA

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CUTA

Gene ID

51596

Gene namecutA divalent cation tolerance homolog
Gene AliasACHAP
Cytomap6p21.32
Gene Typeprotein-coding
GO ID

GO:0008104

UniProtAcc

O60888


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51596CUTAGSM5353244_PA_PR5261_T2_S24_L002HumanProstateTumor2.67e-11-2.11e-010.1569
51596CUTAGSM5353248_PA_PR5269_4_S28_L002HumanProstateTumor1.01e-021.98e-010.1541
51596CUTAP4_S8_cSCCHumanSkincSCC7.42e-096.46e-03-0.3095
51596CUTAP5_S10_cSCCHumanSkincSCC3.13e-11-2.02e-01-0.299
51596CUTAP1_cSCCHumanSkincSCC2.00e-371.52e+000.0292
51596CUTAP2_cSCCHumanSkincSCC1.87e-281.06e+00-0.024
51596CUTAP4_cSCCHumanSkincSCC6.39e-441.22e+00-0.00290000000000005
51596CUTAP10_cSCCHumanSkincSCC1.57e-381.44e+000.1017
51596CUTAcSCC_p11HumanSkincSCC2.49e-029.50e-02-0.2102
51596CUTAcSCC_p4HumanSkincSCC3.26e-048.27e-02-0.2022
51596CUTAcSCC_p7HumanSkincSCC1.75e-03-1.80e-01-0.2332
51596CUTAcSCC_p8HumanSkincSCC2.10e-111.76e-01-0.1971
51596CUTAcSCC_p9HumanSkincSCC8.22e-132.10e-01-0.1991
51596CUTAAdj_PTCwithHT_6HumanThyroidHT2.15e-12-5.30e-010.02
51596CUTAAdj_PTCwithHT_8HumanThyroidHT1.18e-02-3.87e-010.0267
51596CUTAPTCwithHT_1HumanThyroidHT4.75e-04-6.91e-010.0238
51596CUTAPTCwithHT_6HumanThyroidHT2.19e-07-4.04e-010.02
51596CUTAPTCwithHT_8HumanThyroidHT4.30e-04-2.26e-010.0351
51596CUTAPTCwithoutHT_2HumanThyroidPTC8.50e-09-3.07e-010.0419
51596CUTAmale-WTAHumanThyroidPTC5.99e-636.75e-020.1037
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
BreastThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.IDC: Invasive ductal carcinoma
DCIS: Ductal carcinoma in situ
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001003814BreastIDCresponse to metal ion65/1434373/187232.95e-103.42e-0865
GO:001003824BreastDCISresponse to metal ion65/1390373/187238.03e-119.88e-0965
GO:001003810CervixCCresponse to metal ion67/2311373/187239.67e-048.10e-0367
GO:001003815CervixHSIL_HPVresponse to metal ion36/737373/187237.19e-073.65e-0536
GO:0010038ColorectumADresponse to metal ion106/3918373/187233.22e-043.83e-03106
GO:00100381ColorectumSERresponse to metal ion84/2897373/187231.87e-043.44e-0384
GO:00100382ColorectumMSSresponse to metal ion90/3467373/187233.76e-032.76e-0290
GO:00100383ColorectumMSI-Hresponse to metal ion41/1319373/187233.09e-033.87e-0241
GO:001003816EndometriumAEHresponse to metal ion65/2100373/187232.02e-042.54e-0365
GO:001003817EndometriumEECresponse to metal ion66/2168373/187232.86e-043.23e-0366
GO:001003827EsophagusESCCresponse to metal ion208/8552373/187235.02e-053.90e-04208
GO:001003812LiverCirrhoticresponse to metal ion150/4634373/187232.27e-111.37e-09150
GO:001003822LiverHCCresponse to metal ion208/7958373/187231.35e-072.56e-06208
GO:001003820Oral cavityOSCCresponse to metal ion188/7305373/187234.34e-065.00e-05188
GO:0010038110Oral cavityLPresponse to metal ion124/4623373/187231.09e-041.31e-03124
GO:001003818ProstateBPHresponse to metal ion104/3107373/187232.32e-086.99e-07104
GO:001003819ProstateTumorresponse to metal ion107/3246373/187233.02e-089.77e-07107
GO:001003829SkincSCCresponse to metal ion132/4864373/187233.11e-053.42e-04132
GO:001003830ThyroidHTresponse to metal ion50/1272373/187233.12e-061.08e-0450
GO:0010038112ThyroidPTCresponse to metal ion157/5968373/187231.80e-051.86e-04157
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CUTAinsertionFrame_Shift_Insnovelc.421-1_421insTACTGCACAGAGCCATCAGGCCGTACTCTCCGAGCAAGGACCCGGAp.Met141TyrfsTer18p.M141Yfs*18O60888protein_codingTCGA-A8-A097-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
CUTASNVMissense_Mutationc.26C>Tp.Ser9Phep.S9FO60888protein_codingtolerated_low_confidence(1)benign(0)TCGA-IR-A3LK-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
CUTASNVMissense_Mutationnovelc.134N>Tp.Ala45Valp.A45VO60888protein_codingtolerated(0.09)benign(0.003)TCGA-AJ-A3BH-01Endometriumuterine corpus endometrioid carcinomaFemaleUnknownI/IIUnknownUnknownSD
CUTASNVMissense_Mutationnovelc.355N>Gp.Ile119Valp.I119VO60888protein_codingtolerated(0.43)benign(0.02)TCGA-AP-A1DK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
CUTASNVMissense_Mutationnovelc.275T>Cp.Val92Alap.V92AO60888protein_codingdeleterious(0)probably_damaging(0.995)TCGA-B5-A3FA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
CUTASNVMissense_Mutationnovelc.265N>Ap.Ala89Thrp.A89TO60888protein_codingtolerated(0.07)possibly_damaging(0.696)TCGA-DF-A2KU-01Endometriumuterine corpus endometrioid carcinomaFemaleUnknownI/IIUnknownUnknownSD
CUTASNVMissense_Mutationnovelc.346N>Ap.Val116Ilep.V116IO60888protein_codingtolerated(0.06)possibly_damaging(0.829)TCGA-EO-A22R-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
CUTASNVMissense_Mutationrs780611595c.77N>Ap.Ser26Tyrp.S26YO60888protein_codingdeleterious_low_confidence(0)possibly_damaging(0.676)TCGA-EO-A22X-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnspecificCarboplatinComplete Response
CUTASNVMissense_Mutationrs762618918c.227C>Tp.Ser76Leup.S76LO60888protein_codingtolerated(0.19)benign(0.003)TCGA-63-5131-01Lunglung squamous cell carcinomaMaleUnknownI/IIUnknownUnknownSD
CUTASNVMissense_Mutationnovelc.410A>Gp.Glu137Glyp.E137GO60888protein_codingdeleterious(0)probably_damaging(1)TCGA-CQ-5326-01Oral cavityhead & neck squamous cell carcinomaMale>=65I/IIUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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