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Gene: SH3BGRL3 |
Gene summary for SH3BGRL3 |
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Gene information | Species | Human | Gene symbol | SH3BGRL3 | Gene ID | 83442 |
Gene name | SH3 domain binding glutamate rich protein like 3 | |
Gene Alias | HEL-S-297 | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H299 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83442 | SH3BGRL3 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 2.55e-22 | -1.13e+00 | 0.1621 |
83442 | SH3BGRL3 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 5.67e-12 | -1.11e+00 | 0.1619 |
83442 | SH3BGRL3 | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 9.73e-04 | -8.65e-01 | 0.159 |
83442 | SH3BGRL3 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 6.81e-25 | -1.12e+00 | 0.1602 |
83442 | SH3BGRL3 | GSM5353228_PA_PR5199-640K_Pool_1_3_S108_L004 | Human | Prostate | Tumor | 5.61e-06 | -1.22e+00 | 0.1537 |
83442 | SH3BGRL3 | GSM5353232_PA_PR5249_T1_S3_L001 | Human | Prostate | Tumor | 1.37e-09 | -1.32e+00 | 0.1439 |
83442 | SH3BGRL3 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 2.18e-15 | -1.22e+00 | 0.1608 |
83442 | SH3BGRL3 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 2.26e-07 | -1.10e+00 | 0.1622 |
83442 | SH3BGRL3 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 7.78e-32 | -1.04e+00 | 0.1575 |
83442 | SH3BGRL3 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 2.68e-46 | -1.18e+00 | 0.1545 |
83442 | SH3BGRL3 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 4.26e-35 | -1.17e+00 | 0.1569 |
83442 | SH3BGRL3 | GSM5353247_PA_PR5269_3_S27_L002 | Human | Prostate | Tumor | 8.43e-05 | -1.20e+00 | 0.1532 |
83442 | SH3BGRL3 | GSM5353248_PA_PR5269_4_S28_L002 | Human | Prostate | Tumor | 9.49e-06 | -1.08e+00 | 0.1541 |
83442 | SH3BGRL3 | P1_S1_AK | Human | Skin | AK | 1.26e-13 | -3.94e-01 | -0.3399 |
83442 | SH3BGRL3 | P2_S3_AK | Human | Skin | AK | 1.30e-17 | -3.75e-01 | -0.3287 |
83442 | SH3BGRL3 | P2_S4_SCCIS | Human | Skin | SCCIS | 1.75e-09 | -3.43e-01 | -0.3043 |
83442 | SH3BGRL3 | P3_S6_AK | Human | Skin | AK | 4.24e-09 | -5.13e-01 | -0.3256 |
83442 | SH3BGRL3 | P4_S8_cSCC | Human | Skin | cSCC | 8.51e-18 | -8.85e-02 | -0.3095 |
83442 | SH3BGRL3 | P5_S10_cSCC | Human | Skin | cSCC | 2.52e-30 | -8.95e-02 | -0.299 |
83442 | SH3BGRL3 | P1_cSCC | Human | Skin | cSCC | 1.48e-44 | 2.11e+00 | 0.0292 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SH3BGRL3 | SNV | Missense_Mutation | rs373102479 | c.94C>T | p.Arg32Cys | p.R32C | Q9H299 | protein_coding | tolerated(0.14) | benign(0.009) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
SH3BGRL3 | SNV | Missense_Mutation | rs373102479 | c.94N>T | p.Arg32Cys | p.R32C | Q9H299 | protein_coding | tolerated(0.14) | benign(0.009) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SH3BGRL3 | SNV | Missense_Mutation | novel | c.163G>T | p.Gly55Cys | p.G55C | Q9H299 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SH3BGRL3 | SNV | Missense_Mutation | novel | c.220N>C | p.Tyr74His | p.Y74H | Q9H299 | protein_coding | tolerated(0.06) | probably_damaging(0.992) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SH3BGRL3 | SNV | Missense_Mutation | novel | c.147N>C | p.Glu49Asp | p.E49D | Q9H299 | protein_coding | tolerated(0.06) | possibly_damaging(0.811) | TCGA-55-7913-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SH3BGRL3 | SNV | Missense_Mutation | rs200815881 | c.95N>A | p.Arg32His | p.R32H | Q9H299 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-99-8025-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemzar | SD |
SH3BGRL3 | SNV | Missense_Mutation | novel | c.131N>G | p.Asn44Ser | p.N44S | Q9H299 | protein_coding | tolerated(0.65) | benign(0.03) | TCGA-CR-7370-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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