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Gene: SELM |
Gene summary for SELM |
Gene summary. |
Gene information | Species | Human | Gene symbol | SELM | Gene ID | 140606 |
Gene name | selenoprotein M | |
Gene Alias | SELM | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q8WWX9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140606 | SELM | P3_S6_AK | Human | Skin | AK | 1.64e-25 | -6.62e-01 | -0.3256 |
140606 | SELM | P4_S8_cSCC | Human | Skin | cSCC | 9.07e-18 | -6.62e-01 | -0.3095 |
140606 | SELM | P5_S10_cSCC | Human | Skin | cSCC | 3.95e-25 | -6.62e-01 | -0.299 |
140606 | SELM | cSCC_p1 | Human | Skin | cSCC | 3.95e-25 | -6.62e-01 | -0.1916 |
140606 | SELM | cSCC_p10 | Human | Skin | cSCC | 3.95e-25 | -6.62e-01 | -0.2095 |
140606 | SELM | cSCC_p11 | Human | Skin | cSCC | 6.83e-26 | -6.62e-01 | -0.2102 |
140606 | SELM | cSCC_p3 | Human | Skin | cSCC | 3.95e-25 | -6.62e-01 | -0.2085 |
140606 | SELM | cSCC_p4 | Human | Skin | cSCC | 4.00e-22 | -6.62e-01 | -0.2022 |
140606 | SELM | cSCC_p6 | Human | Skin | cSCC | 5.40e-24 | -6.62e-01 | -0.1989 |
140606 | SELM | cSCC_p7 | Human | Skin | cSCC | 4.00e-22 | -6.62e-01 | -0.2332 |
140606 | SELM | cSCC_p8 | Human | Skin | cSCC | 3.95e-25 | -6.62e-01 | -0.1971 |
140606 | SELM | cSCC_p9 | Human | Skin | cSCC | 1.64e-25 | -6.62e-01 | -0.1991 |
140606 | SELM | Adj_PTCwithHT_6 | Human | Thyroid | HT | 9.97e-09 | -5.32e-01 | 0.02 |
140606 | SELM | PTCwithHT_6 | Human | Thyroid | HT | 1.61e-04 | -4.23e-01 | 0.02 |
140606 | SELM | PTCwithoutHT_2 | Human | Thyroid | PTC | 7.59e-03 | -3.29e-01 | 0.0419 |
140606 | SELM | male-WTA | Human | Thyroid | PTC | 2.80e-17 | -6.16e-01 | 0.1037 |
140606 | SELM | female-WTA | Human | Thyroid | PTC | 6.99e-07 | -6.16e-01 | 0.0726 |
140606 | SELM | nodule-WTA | Human | Thyroid | goiters | 7.05e-16 | -6.16e-01 | 0.0534 |
140606 | SELM | PTC01 | Human | Thyroid | PTC | 7.43e-16 | -6.16e-01 | 0.1899 |
140606 | SELM | PTC03 | Human | Thyroid | PTC | 4.08e-05 | -6.16e-01 | 0.1784 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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