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Gene: S100A11 |
Gene summary for S100A11 |
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Gene information | Species | Human | Gene symbol | S100A11 | Gene ID | 6282 |
Gene name | S100 calcium binding protein A11 | |
Gene Alias | HEL-S-43 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006260 | UniProtAcc | P31949 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6282 | S100A11 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 9.29e-06 | -1.16e-01 | -0.1406 |
6282 | S100A11 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.23e-05 | -3.69e-01 | -0.1408 |
6282 | S100A11 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 6.42e-04 | -4.41e-01 | -0.138 |
6282 | S100A11 | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.14e-04 | 3.82e-01 | 0.3371 |
6282 | S100A11 | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.20e-06 | 4.82e-01 | 0.343 |
6282 | S100A11 | RNA-P17T-P17T-6 | Human | Lung | IAC | 9.77e-07 | 2.93e-01 | 0.3385 |
6282 | S100A11 | RNA-P17T-P17T-8 | Human | Lung | IAC | 4.66e-10 | 2.79e-01 | 0.3329 |
6282 | S100A11 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 7.42e-17 | 2.72e-02 | -0.2116 |
6282 | S100A11 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.52e-08 | -2.96e-03 | -0.1941 |
6282 | S100A11 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 1.36e-07 | -7.89e-02 | -0.2107 |
6282 | S100A11 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 5.99e-14 | -2.38e-02 | -0.2119 |
6282 | S100A11 | RNA-P3T-P3T-2 | Human | Lung | IAC | 2.55e-02 | 2.64e-01 | 0.1835 |
6282 | S100A11 | RNA-P3T-P3T-4 | Human | Lung | IAC | 9.52e-06 | 4.02e-01 | 0.1859 |
6282 | S100A11 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 1.01e-02 | -6.15e-01 | -0.0238 |
6282 | S100A11 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.54e-24 | -3.36e-01 | -0.0166 |
6282 | S100A11 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 9.67e-26 | -1.97e-01 | -0.0132 |
6282 | S100A11 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 8.30e-32 | -2.72e-01 | -0.013 |
6282 | S100A11 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.03e-17 | -2.68e-01 | -0.0121 |
6282 | S100A11 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 1.02e-05 | 3.18e-01 | -0.0961 |
6282 | S100A11 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 4.23e-05 | 4.79e-01 | -0.0876 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
GO:0006260 | Colorectum | MSI-H | DNA replication | 31/1319 | 260/18723 | 2.83e-03 | 3.63e-02 | 31 |
GO:0006275 | Colorectum | CRC | regulation of DNA replication | 21/2078 | 107/18723 | 6.56e-03 | 4.70e-02 | 21 |
GO:00149103 | Endometrium | AEH | regulation of smooth muscle cell migration | 19/2100 | 89/18723 | 4.12e-03 | 2.73e-02 | 19 |
GO:00149092 | Endometrium | AEH | smooth muscle cell migration | 20/2100 | 97/18723 | 5.00e-03 | 3.14e-02 | 20 |
GO:00062752 | Endometrium | AEH | regulation of DNA replication | 21/2100 | 107/18723 | 7.38e-03 | 4.20e-02 | 21 |
GO:000627511 | Endometrium | EEC | regulation of DNA replication | 22/2168 | 107/18723 | 5.09e-03 | 3.20e-02 | 22 |
GO:001491011 | Endometrium | EEC | regulation of smooth muscle cell migration | 19/2168 | 89/18723 | 5.83e-03 | 3.49e-02 | 19 |
GO:001490911 | Endometrium | EEC | smooth muscle cell migration | 20/2168 | 97/18723 | 7.11e-03 | 4.07e-02 | 20 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:00062754 | Esophagus | ESCC | regulation of DNA replication | 73/8552 | 107/18723 | 1.97e-06 | 2.28e-05 | 73 |
GO:0014911 | Liver | NAFLD | positive regulation of smooth muscle cell migration | 11/1882 | 47/18723 | 5.92e-03 | 4.47e-02 | 11 |
GO:0014910 | Liver | NAFLD | regulation of smooth muscle cell migration | 17/1882 | 89/18723 | 6.91e-03 | 4.87e-02 | 17 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:00062751 | Liver | HCC | regulation of DNA replication | 60/7958 | 107/18723 | 3.15e-03 | 1.46e-02 | 60 |
GO:00149102 | Lung | IAC | regulation of smooth muscle cell migration | 19/2061 | 89/18723 | 3.35e-03 | 2.87e-02 | 19 |
GO:0014909 | Lung | IAC | smooth muscle cell migration | 20/2061 | 97/18723 | 4.05e-03 | 3.31e-02 | 20 |
GO:00149091 | Lung | AIS | smooth muscle cell migration | 19/1849 | 97/18723 | 2.74e-03 | 2.75e-02 | 19 |
GO:0014812 | Lung | AIS | muscle cell migration | 20/1849 | 110/18723 | 5.24e-03 | 4.49e-02 | 20 |
GO:00149101 | Lung | AIS | regulation of smooth muscle cell migration | 17/1849 | 89/18723 | 5.80e-03 | 4.83e-02 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
S100A11 | SNV | Missense_Mutation | c.211A>G | p.Ser71Gly | p.S71G | P31949 | protein_coding | tolerated(0.48) | benign(0.01) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
S100A11 | SNV | Missense_Mutation | novel | c.104N>T | p.Ser35Phe | p.S35F | P31949 | protein_coding | deleterious(0.01) | probably_damaging(0.93) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
S100A11 | SNV | Missense_Mutation | c.74C>T | p.Ala25Val | p.A25V | P31949 | protein_coding | deleterious(0.02) | benign(0.194) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
S100A11 | SNV | Missense_Mutation | c.169N>T | p.Pro57Ser | p.P57S | P31949 | protein_coding | deleterious(0.01) | possibly_damaging(0.615) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
S100A11 | SNV | Missense_Mutation | novel | c.34C>T | p.Arg12Trp | p.R12W | P31949 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
S100A11 | SNV | Missense_Mutation | novel | c.59N>C | p.Val20Ala | p.V20A | P31949 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
S100A11 | SNV | Missense_Mutation | c.8N>C | p.Lys3Thr | p.K3T | P31949 | protein_coding | deleterious_low_confidence(0) | benign(0.001) | TCGA-93-A4JQ-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
S100A11 | SNV | Missense_Mutation | novel | c.178C>T | p.Leu60Phe | p.L60F | P31949 | protein_coding | tolerated(0.06) | benign(0.423) | TCGA-CV-7104-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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