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Gene: RPL31 |
Gene summary for RPL31 |
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Gene information | Species | Human | Gene symbol | RPL31 | Gene ID | 6160 |
Gene name | ribosomal protein L31 | |
Gene Alias | L31 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | P62899 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6160 | RPL31 | cirrhotic3 | Human | Liver | Cirrhotic | 4.83e-28 | 4.50e-01 | 0.0215 |
6160 | RPL31 | p6 | Human | Liver | Cyst | 1.19e-02 | 5.75e-01 | -0.0218 |
6160 | RPL31 | HCC1 | Human | Liver | HCC | 1.00e-32 | 5.35e+00 | 0.5336 |
6160 | RPL31 | HCC2 | Human | Liver | HCC | 2.56e-19 | 4.81e+00 | 0.5341 |
6160 | RPL31 | HCC5 | Human | Liver | HCC | 1.20e-04 | 2.57e+00 | 0.4932 |
6160 | RPL31 | Pt13.a | Human | Liver | HCC | 2.17e-40 | 2.15e-01 | 0.021 |
6160 | RPL31 | Pt13.b | Human | Liver | HCC | 5.79e-50 | 2.47e-01 | 0.0251 |
6160 | RPL31 | Pt13.c | Human | Liver | HCC | 2.72e-11 | 8.21e-02 | 0.0076 |
6160 | RPL31 | Pt14.a | Human | Liver | HCC | 7.93e-05 | 3.42e-01 | 0.0169 |
6160 | RPL31 | Pt14.b | Human | Liver | HCC | 7.23e-07 | 3.43e-01 | 0.018 |
6160 | RPL31 | Pt14.d | Human | Liver | HCC | 6.98e-29 | 2.57e-01 | 0.0143 |
6160 | RPL31 | S014 | Human | Liver | HCC | 3.21e-32 | 2.50e+00 | 0.2254 |
6160 | RPL31 | S015 | Human | Liver | HCC | 2.97e-30 | 3.02e+00 | 0.2375 |
6160 | RPL31 | S016 | Human | Liver | HCC | 2.22e-27 | 2.68e+00 | 0.2243 |
6160 | RPL31 | S027 | Human | Liver | HCC | 2.45e-16 | 3.26e+00 | 0.2446 |
6160 | RPL31 | S028 | Human | Liver | HCC | 3.05e-31 | 3.37e+00 | 0.2503 |
6160 | RPL31 | S029 | Human | Liver | HCC | 1.38e-30 | 3.18e+00 | 0.2581 |
6160 | RPL31 | TD9 | Human | Lung | IAC | 1.49e-05 | -5.85e-01 | 0.088 |
6160 | RPL31 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 2.13e-02 | -4.23e-01 | -0.138 |
6160 | RPL31 | RNA-P17T-P17T-2 | Human | Lung | IAC | 3.11e-05 | -3.06e-01 | 0.3371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:000218125 | Cervix | N_HPV | cytoplasmic translation | 42/534 | 148/18723 | 2.61e-30 | 1.19e-26 | 42 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00021813 | Colorectum | MSI-H | cytoplasmic translation | 100/1319 | 148/18723 | 1.50e-79 | 8.31e-76 | 100 |
GO:00021814 | Colorectum | FAP | cytoplasmic translation | 76/2622 | 148/18723 | 3.31e-27 | 2.03e-23 | 76 |
GO:00021815 | Colorectum | CRC | cytoplasmic translation | 70/2078 | 148/18723 | 1.53e-28 | 9.16e-25 | 70 |
GO:000218116 | Endometrium | AEH | cytoplasmic translation | 104/2100 | 148/18723 | 1.01e-64 | 6.07e-61 | 104 |
GO:000218117 | Endometrium | EEC | cytoplasmic translation | 104/2168 | 148/18723 | 2.53e-63 | 1.52e-59 | 104 |
GO:000218127 | Esophagus | HGIN | cytoplasmic translation | 108/2587 | 148/18723 | 1.70e-60 | 1.02e-56 | 108 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:00021817 | Liver | NAFLD | cytoplasmic translation | 93/1882 | 148/18723 | 1.44e-55 | 8.41e-52 | 93 |
GO:000218112 | Liver | Cirrhotic | cytoplasmic translation | 120/4634 | 148/18723 | 2.95e-47 | 1.85e-43 | 120 |
GO:000218122 | Liver | HCC | cytoplasmic translation | 132/7958 | 148/18723 | 9.09e-33 | 5.76e-30 | 132 |
GO:000218132 | Liver | Cyst | cytoplasmic translation | 70/496 | 148/18723 | 9.01e-71 | 3.85e-67 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL31 | SNV | Missense_Mutation | c.254N>A | p.Arg85His | p.R85H | P62899 | protein_coding | tolerated(0.42) | benign(0.021) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
RPL31 | SNV | Missense_Mutation | c.30N>T | p.Lys10Asn | p.K10N | P62899 | protein_coding | deleterious(0.03) | benign(0.176) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPL31 | SNV | Missense_Mutation | c.167A>G | p.Glu56Gly | p.E56G | P62899 | protein_coding | deleterious(0.05) | benign(0.104) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RPL31 | SNV | Missense_Mutation | c.281N>T | p.Glu94Val | p.E94V | P62899 | protein_coding | deleterious(0.03) | possibly_damaging(0.619) | TCGA-AA-3870-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | |
RPL31 | SNV | Missense_Mutation | novel | c.329N>A | p.Pro110His | p.P110H | P62899 | protein_coding | deleterious(0.02) | possibly_damaging(0.625) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RPL31 | SNV | Missense_Mutation | novel | c.47N>T | p.Ala16Val | p.A16V | P62899 | protein_coding | tolerated(0.06) | benign(0.157) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
RPL31 | SNV | Missense_Mutation | novel | c.74A>G | p.Tyr25Cys | p.Y25C | P62899 | protein_coding | tolerated(0.06) | benign(0.182) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RPL31 | SNV | Missense_Mutation | rs1065720 | c.284N>G | p.Asp95Gly | p.D95G | P62899 | protein_coding | deleterious(0.01) | benign(0.25) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL31 | SNV | Missense_Mutation | novel | c.31N>G | p.Lys11Glu | p.K11E | P62899 | protein_coding | deleterious(0.05) | benign(0.188) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL31 | SNV | Missense_Mutation | novel | c.154N>G | p.Phe52Val | p.F52V | P62899 | protein_coding | deleterious(0.02) | possibly_damaging(0.566) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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