Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10299 | MARCH6 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 1.44e-03 | 4.32e-01 | 0.1633 |
10299 | MARCH6 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 9.70e-06 | 4.03e-01 | 0.1608 |
10299 | MARCH6 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 9.56e-03 | 4.59e-01 | 0.1621 |
10299 | MARCH6 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 6.94e-10 | 3.97e-01 | 0.1602 |
10299 | MARCH6 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 3.59e-05 | 4.79e-01 | 0.1608 |
10299 | MARCH6 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 6.41e-04 | 1.58e-01 | 0.1575 |
10299 | MARCH6 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 2.44e-15 | 1.25e-01 | 0.1545 |
10299 | MARCH6 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 3.18e-04 | 5.00e-02 | 0.1569 |
10299 | MARCH6 | GSM5353248_PA_PR5269_4_S28_L002 | Human | Prostate | Tumor | 1.83e-04 | -9.71e-02 | 0.1541 |
10299 | MARCH6 | P1_S1_AK | Human | Skin | AK | 1.39e-05 | 3.64e-01 | -0.3399 |
10299 | MARCH6 | P2_S3_AK | Human | Skin | AK | 1.06e-08 | 3.93e-01 | -0.3287 |
10299 | MARCH6 | P3_S6_AK | Human | Skin | AK | 2.53e-06 | 3.25e-01 | -0.3256 |
10299 | MARCH6 | P4_S8_cSCC | Human | Skin | cSCC | 4.58e-13 | 2.85e-01 | -0.3095 |
10299 | MARCH6 | P5_S10_cSCC | Human | Skin | cSCC | 1.48e-03 | 1.23e-01 | -0.299 |
10299 | MARCH6 | P1_cSCC | Human | Skin | cSCC | 3.15e-14 | 6.22e-01 | 0.0292 |
10299 | MARCH6 | P2_cSCC | Human | Skin | cSCC | 2.56e-06 | 2.72e-01 | -0.024 |
10299 | MARCH6 | P4_cSCC | Human | Skin | cSCC | 1.23e-03 | 2.17e-01 | -0.00290000000000005 |
10299 | MARCH6 | P10_cSCC | Human | Skin | cSCC | 2.44e-11 | 5.11e-01 | 0.1017 |
10299 | MARCH6 | PTCwithHT_6 | Human | Thyroid | HT | 9.51e-04 | -2.86e-01 | 0.02 |
10299 | MARCH6 | male-WTA | Human | Thyroid | PTC | 7.64e-52 | 2.50e-01 | 0.1037 |
Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/MARCH6_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/MARCH6_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/MARCH6_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/MARCH6_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/MARCH6_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/MARCH6_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/MARCH6_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/MARCH6_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/MARCH6_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/MARCH6_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MARCH6 | SNV | Missense_Mutation | novel | c.838N>G | p.Leu280Val | p.L280V | O60337 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
MARCH6 | insertion | Frame_Shift_Ins | novel | c.1410_1411insAAAGTGTTATTTAATT | p.Leu471LysfsTer10 | p.L471Kfs*10 | O60337 | protein_coding | | | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
MARCH6 | insertion | Frame_Shift_Ins | novel | c.1526_1527insCAGAAGAAGAAATTACATAGTTAAA | p.Leu510ArgfsTer18 | p.L510Rfs*18 | O60337 | protein_coding | | | TCGA-BH-A0H9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
MARCH6 | insertion | Frame_Shift_Ins | novel | c.2558dupT | p.Leu853PhefsTer19 | p.L853Ffs*19 | O60337 | protein_coding | | | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MARCH6 | SNV | Missense_Mutation | | c.922C>T | p.Pro308Ser | p.P308S | O60337 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MARCH6 | SNV | Missense_Mutation | | c.55N>A | p.Glu19Lys | p.E19K | O60337 | protein_coding | deleterious(0) | benign(0.052) | TCGA-BI-A0VR-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
MARCH6 | SNV | Missense_Mutation | | c.2263C>G | p.Pro755Ala | p.P755A | O60337 | protein_coding | deleterious(0.01) | possibly_damaging(0.527) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
MARCH6 | SNV | Missense_Mutation | | c.1979N>A | p.Arg660His | p.R660H | O60337 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C5-A1MN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
MARCH6 | SNV | Missense_Mutation | novel | c.565N>T | p.His189Tyr | p.H189Y | O60337 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
MARCH6 | SNV | Missense_Mutation | | c.55N>C | p.Glu19Gln | p.E19Q | O60337 | protein_coding | deleterious(0) | benign(0.096) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |