Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MAML2

Gene summary for MAML2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MAML2

Gene ID

84441

Gene namemastermind like transcriptional coactivator 2
Gene AliasMAM-3
Cytomap11q21
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

Q8IZL2


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
84441MAML2ATC5HumanThyroidATC5.84e-297.01e-010.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00072194CervixCCNotch signaling pathway39/2311172/187231.08e-041.38e-0339
GO:0007219ColorectumADNotch signaling pathway50/3918172/187236.92e-034.26e-0250
GO:00072191ColorectumFAPNotch signaling pathway38/2622172/187232.56e-032.01e-0238
GO:00072192ColorectumCRCNotch signaling pathway36/2078172/187231.26e-042.42e-0336
GO:00072197EsophagusESCCNotch signaling pathway106/8552172/187231.74e-051.55e-04106
GO:00072193LungAISNotch signaling pathway29/1849172/187232.93e-032.92e-0229
GO:00072196Oral cavityOSCCNotch signaling pathway92/7305172/187237.84e-056.08e-0492
GO:000721921Oral cavityNEOLPNotch signaling pathway32/2005172/187231.31e-039.48e-0332
GO:00072195ProstateBPHNotch signaling pathway41/3107172/187238.95e-033.83e-0241
GO:000721912ProstateTumorNotch signaling pathway44/3246172/187234.02e-032.04e-0244
GO:00072198SkinAKNotch signaling pathway34/1910172/187231.20e-041.50e-0334
GO:000721914SkinSCCISNotch signaling pathway17/919172/187234.79e-033.95e-0217
GO:000721922SkincSCCNotch signaling pathway60/4864172/187235.82e-032.87e-0260
GO:00072199ThyroidPTCNotch signaling pathway70/5968172/187238.82e-033.67e-0270
GO:000721915ThyroidATCNotch signaling pathway79/6293172/187235.08e-042.96e-0379
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa051657CervixCCHuman papillomavirus infection74/1267331/84651.70e-041.02e-036.03e-0474
hsa04658CervixCCTh1 and Th2 cell differentiation24/126792/84653.71e-031.34e-027.91e-0324
hsa04330CervixCCNotch signaling pathway17/126762/84657.99e-032.56e-021.51e-0217
hsa0516512CervixCCHuman papillomavirus infection74/1267331/84651.70e-041.02e-036.03e-0474
hsa046581CervixCCTh1 and Th2 cell differentiation24/126792/84653.71e-031.34e-027.91e-0324
hsa043301CervixCCNotch signaling pathway17/126762/84657.99e-032.56e-021.51e-0217
hsa0516510EsophagusESCCHuman papillomavirus infection215/4205331/84657.86e-097.12e-083.65e-08215
hsa043306EsophagusESCCNotch signaling pathway42/420562/84652.97e-037.97e-034.08e-0342
hsa046585EsophagusESCCTh1 and Th2 cell differentiation58/420592/84656.49e-031.60e-028.19e-0358
hsa0516515EsophagusESCCHuman papillomavirus infection215/4205331/84657.86e-097.12e-083.65e-08215
hsa0433013EsophagusESCCNotch signaling pathway42/420562/84652.97e-037.97e-034.08e-0342
hsa0465812EsophagusESCCTh1 and Th2 cell differentiation58/420592/84656.49e-031.60e-028.19e-0358
hsa051656LungIACHuman papillomavirus infection71/1053331/84651.88e-067.63e-055.06e-0571
hsa0516511LungIACHuman papillomavirus infection71/1053331/84651.88e-067.63e-055.06e-0571
hsa0516521LungAISHuman papillomavirus infection64/961331/84651.03e-053.04e-041.95e-0464
hsa0516531LungAISHuman papillomavirus infection64/961331/84651.03e-053.04e-041.95e-0464
hsa051654LungMIACHuman papillomavirus infection32/507331/84654.78e-033.49e-022.52e-0232
hsa051655LungMIACHuman papillomavirus infection32/507331/84654.78e-033.49e-022.52e-0232
hsa051659Oral cavityOSCCHuman papillomavirus infection200/3704331/84653.83e-104.93e-092.51e-09200
hsa043305Oral cavityOSCCNotch signaling pathway44/370462/84651.26e-055.55e-052.83e-0544
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MAML2SNVMissense_Mutationc.2395N>Ap.Pro799Thrp.P799TQ8IZL2protein_codingdeleterious(0)probably_damaging(0.997)TCGA-A8-A09A-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
MAML2SNVMissense_Mutationc.1715N>Tp.Pro572Leup.P572LQ8IZL2protein_codingdeleterious(0)benign(0.241)TCGA-AN-A0XU-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
MAML2SNVMissense_Mutationnovelc.2868N>Ap.Met956Ilep.M956IQ8IZL2protein_codingtolerated(0.06)benign(0)TCGA-AQ-A54O-01Breastbreast invasive carcinomaMale<65I/IIChemotherapyadriamycinCR
MAML2SNVMissense_Mutationc.182N>Ap.Gly61Aspp.G61DQ8IZL2protein_codingdeleterious(0.01)probably_damaging(0.991)TCGA-BH-A18G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
MAML2SNVMissense_Mutationrs199840764c.341N>Tp.Ala114Valp.A114VQ8IZL2protein_codingtolerated(1)benign(0)TCGA-BH-A18L-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
MAML2SNVMissense_Mutationc.199N>Ap.Asp67Asnp.D67NQ8IZL2protein_codingdeleterious(0)probably_damaging(0.999)TCGA-BH-A1EV-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownPD
MAML2SNVMissense_Mutationnovelc.715N>Gp.Pro239Alap.P239AQ8IZL2protein_codingtolerated(0.46)benign(0.009)TCGA-BH-A6R9-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
MAML2SNVMissense_Mutationnovelc.2725N>Tp.Pro909Serp.P909SQ8IZL2protein_codingtolerated(0.88)benign(0.046)TCGA-D8-A1JG-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
MAML2SNVMissense_Mutationc.2995N>Ap.Ser999Thrp.S999TQ8IZL2protein_codingtolerated(0.37)benign(0.023)TCGA-E9-A245-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
MAML2insertionFrame_Shift_Insnovelc.1618_1619insTACTAATTAGAGAACTCTGGCTGAATp.Ser540IlefsTer150p.S540Ifs*150Q8IZL2protein_codingTCGA-A2-A0EV-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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