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Gene: IFI27 |
Gene summary for IFI27 |
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Gene information | Species | Human | Gene symbol | IFI27 | Gene ID | 3429 |
Gene name | interferon alpha inducible protein 27 | |
Gene Alias | FAM14D | |
Cytomap | 14q32.12 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A8K0H0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3429 | IFI27 | LN38 | Human | Oral cavity | OSCC | 4.72e-07 | 2.78e+00 | 0.168 |
3429 | IFI27 | LN46 | Human | Oral cavity | OSCC | 6.81e-47 | 4.81e+00 | 0.1666 |
3429 | IFI27 | LP15 | Human | Oral cavity | LP | 2.26e-20 | 4.74e+00 | 0.2174 |
3429 | IFI27 | LP17 | Human | Oral cavity | LP | 1.66e-15 | 6.14e+00 | 0.2349 |
3429 | IFI27 | EOLP-1 | Human | Oral cavity | EOLP | 3.95e-05 | -4.47e-01 | -0.0202 |
3429 | IFI27 | NEOLP-2 | Human | Oral cavity | NEOLP | 4.61e-02 | -1.85e-01 | -0.0196 |
3429 | IFI27 | SYSMH1 | Human | Oral cavity | OSCC | 1.50e-05 | 7.65e-01 | 0.1127 |
3429 | IFI27 | SYSMH2 | Human | Oral cavity | OSCC | 2.10e-87 | 5.34e+00 | 0.2326 |
3429 | IFI27 | SYSMH3 | Human | Oral cavity | OSCC | 1.28e-96 | 6.08e+00 | 0.2442 |
3429 | IFI27 | SYSMH4 | Human | Oral cavity | OSCC | 2.69e-50 | 2.25e+00 | 0.1226 |
3429 | IFI27 | SYSMH5 | Human | Oral cavity | OSCC | 2.66e-56 | 3.24e+00 | 0.0647 |
3429 | IFI27 | SYSMH6 | Human | Oral cavity | OSCC | 8.59e-06 | 3.52e+00 | 0.1275 |
3429 | IFI27 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 1.31e-03 | 9.25e-02 | -0.23 |
3429 | IFI27 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 5.18e-06 | 1.86e-01 | -0.23 |
3429 | IFI27 | Dong_P1 | Human | Prostate | Tumor | 1.33e-26 | 3.95e-01 | 0.035 |
3429 | IFI27 | Dong_P3 | Human | Prostate | Tumor | 4.55e-30 | 4.81e-01 | 0.0278 |
3429 | IFI27 | Dong_P4 | Human | Prostate | Tumor | 1.16e-08 | 4.42e-01 | 0.0292 |
3429 | IFI27 | Dong_P5 | Human | Prostate | Tumor | 7.56e-131 | 1.80e+00 | 0.053 |
3429 | IFI27 | Dong_P6 | Human | Prostate | Tumor | 1.90e-10 | 8.94e-01 | 0.0371 |
3429 | IFI27 | P2_S3_AK | Human | Skin | AK | 2.40e-20 | -5.45e-01 | -0.3287 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
GO:001907914 | Breast | IDC | viral genome replication | 32/1434 | 131/18723 | 2.82e-09 | 2.46e-07 | 32 |
GO:001049814 | Breast | IDC | proteasomal protein catabolic process | 75/1434 | 490/18723 | 5.59e-09 | 4.41e-07 | 75 |
GO:004440314 | Breast | IDC | biological process involved in symbiotic interaction | 52/1434 | 290/18723 | 6.55e-09 | 5.03e-07 | 52 |
GO:009719114 | Breast | IDC | extrinsic apoptotic signaling pathway | 42/1434 | 219/18723 | 2.56e-08 | 1.73e-06 | 42 |
GO:004316114 | Breast | IDC | proteasome-mediated ubiquitin-dependent protein catabolic process | 57/1434 | 412/18723 | 9.55e-06 | 2.68e-04 | 57 |
GO:00517025 | Breast | IDC | biological process involved in interaction with symbiont | 18/1434 | 94/18723 | 2.46e-04 | 3.85e-03 | 18 |
GO:00096157 | Breast | IDC | response to virus | 47/1434 | 367/18723 | 3.53e-04 | 5.16e-03 | 47 |
GO:00447883 | Breast | IDC | modulation by host of viral process | 8/1434 | 30/18723 | 1.48e-03 | 1.50e-02 | 8 |
GO:00518513 | Breast | IDC | modulation by host of symbiont process | 12/1434 | 60/18723 | 1.73e-03 | 1.69e-02 | 12 |
GO:00331578 | Breast | IDC | regulation of intracellular protein transport | 29/1434 | 229/18723 | 5.16e-03 | 3.84e-02 | 29 |
GO:00468258 | Breast | IDC | regulation of protein export from nucleus | 7/1434 | 30/18723 | 6.48e-03 | 4.56e-02 | 7 |
GO:00358214 | Breast | IDC | modulation of process of other organism | 16/1434 | 106/18723 | 6.70e-03 | 4.66e-02 | 16 |
GO:001603224 | Breast | DCIS | viral process | 73/1390 | 415/18723 | 3.40e-12 | 6.88e-10 | 73 |
GO:001905824 | Breast | DCIS | viral life cycle | 59/1390 | 317/18723 | 4.05e-11 | 5.74e-09 | 59 |
GO:001049824 | Breast | DCIS | proteasomal protein catabolic process | 75/1390 | 490/18723 | 1.44e-09 | 1.40e-07 | 75 |
GO:001907923 | Breast | DCIS | viral genome replication | 30/1390 | 131/18723 | 2.12e-08 | 1.45e-06 | 30 |
GO:004440323 | Breast | DCIS | biological process involved in symbiotic interaction | 49/1390 | 290/18723 | 4.70e-08 | 2.89e-06 | 49 |
GO:009719123 | Breast | DCIS | extrinsic apoptotic signaling pathway | 40/1390 | 219/18723 | 9.43e-08 | 5.28e-06 | 40 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFI27 | SNV | Missense_Mutation | novel | c.92N>T | p.Ala31Val | p.A31V | protein_coding | tolerated(0.35) | benign(0.006) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
IFI27 | SNV | Missense_Mutation | rs771278257 | c.344C>T | p.Ala115Val | p.A115V | protein_coding | tolerated(0.1) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
IFI27 | SNV | Missense_Mutation | rs755125237 | c.251N>T | p.Ser84Leu | p.S84L | protein_coding | deleterious(0) | benign(0.062) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
IFI27 | SNV | Missense_Mutation | rs534344668 | c.301G>A | p.Gly101Arg | p.G101R | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IFI27 | SNV | Missense_Mutation | novel | c.197N>C | p.Ile66Thr | p.I66T | protein_coding | deleterious(0.02) | benign(0.333) | TCGA-46-6025-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | |
IFI27 | SNV | Missense_Mutation | novel | c.296T>G | p.Leu99Arg | p.L99R | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-51-4079-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3429 | IFI27 | NUCLEAR HORMONE RECEPTOR | TNF-ALPHA | 15086558 | ||
3429 | IFI27 | NUCLEAR HORMONE RECEPTOR | RETINOIDS | 15086558 | ||
3429 | IFI27 | NUCLEAR HORMONE RECEPTOR | VITAMIN D | 15086558 | ||
3429 | IFI27 | NUCLEAR HORMONE RECEPTOR | TGFBETA1 | 15086558 |
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