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Gene: GAS5 |
Gene summary for GAS5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GAS5 | Gene ID | 60674 |
| Gene name | growth arrest specific 5 | |
| Gene Alias | NCRNA00030 | |
| Cytomap | 1q25.1 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 60674 | GAS5 | Pat07-B | Human | Stomach | GC | 3.12e-11 | 7.47e-01 | 0.0935 |
| 60674 | GAS5 | Pat08-B | Human | Stomach | GC | 3.95e-03 | 2.68e-01 | 0.0182 |
| 60674 | GAS5 | Pat09-B | Human | Stomach | GC | 2.85e-10 | 8.61e-02 | -0.0359 |
| 60674 | GAS5 | Pat10-B | Human | Stomach | GC | 6.42e-04 | -5.72e-02 | 0.084 |
| 60674 | GAS5 | Pat11-B | Human | Stomach | GC | 6.98e-20 | 1.05e-01 | -0.182 |
| 60674 | GAS5 | Pat12-B | Human | Stomach | GC | 8.87e-21 | -1.66e-01 | 0.0325 |
| 60674 | GAS5 | Pat13-B | Human | Stomach | GC | 2.81e-12 | -6.87e-02 | 0.0555 |
| 60674 | GAS5 | Pat15-B | Human | Stomach | GC | 3.65e-24 | -1.92e-01 | -0.0778 |
| 60674 | GAS5 | Pat16-B | Human | Stomach | GC | 2.17e-15 | 2.28e-01 | 0.1918 |
| 60674 | GAS5 | Pat17-B | Human | Stomach | GC | 9.79e-05 | 2.85e-02 | 0.3109 |
| 60674 | GAS5 | Pat18-B | Human | Stomach | GC | 2.51e-19 | -5.92e-02 | -0.0432 |
| 60674 | GAS5 | Pat19-B | Human | Stomach | GC | 3.93e-14 | 9.61e-02 | 0.0826 |
| 60674 | GAS5 | Pat22-B | Human | Stomach | GC | 9.93e-48 | 4.40e-02 | -0.1042 |
| 60674 | GAS5 | Pat24-B | Human | Stomach | GC | 1.88e-13 | 1.47e-02 | -0.1184 |
| 60674 | GAS5 | Pat25-A | Human | Stomach | CAG with IM | 9.79e-53 | 3.99e-01 | -0.1648 |
| 60674 | GAS5 | Pat26-A | Human | Stomach | CSG | 1.27e-56 | 4.54e-01 | -0.2402 |
| 60674 | GAS5 | Pat28-A | Human | Stomach | CSG | 5.59e-26 | 3.48e-01 | -0.2594 |
| 60674 | GAS5 | Pat29-A | Human | Stomach | CAG with IM | 2.39e-22 | 4.01e-01 | -0.2769 |
| 60674 | GAS5 | NAG_1 | Human | Stomach | CSG | 4.22e-26 | -1.00e+00 | -0.3534 |
| 60674 | GAS5 | NAG_2 | Human | Stomach | CSG | 1.37e-23 | -1.00e+00 | -0.3324 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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