Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1973 | EIF4A1 | GSM5252127_BPH283PrSF_Via | Human | Prostate | BPH | 1.36e-09 | 4.57e-01 | -0.1453 |
1973 | EIF4A1 | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 6.69e-35 | 1.02e+00 | -0.1688 |
1973 | EIF4A1 | GSM5252129_BPH327PrSF_Via | Human | Prostate | BPH | 1.99e-28 | 9.71e-01 | -0.1697 |
1973 | EIF4A1 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 8.20e-61 | 1.81e+00 | -0.1972 |
1973 | EIF4A1 | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 1.32e-57 | 1.50e+00 | -0.2126 |
1973 | EIF4A1 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 3.00e-18 | 1.90e+00 | -0.2247 |
1973 | EIF4A1 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 5.56e-24 | 2.14e+00 | -0.2027 |
1973 | EIF4A1 | GSM5252134_BPH511PrG_Fcol_3GEX | Human | Prostate | BPH | 4.58e-41 | 1.09e+00 | -0.1433 |
1973 | EIF4A1 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 2.92e-49 | 1.77e+00 | -0.1833 |
1973 | EIF4A1 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 2.41e-25 | 1.59e+00 | -0.23 |
1973 | EIF4A1 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 2.11e-28 | 1.80e+00 | -0.23 |
1973 | EIF4A1 | 047563_1562-all-cells | Human | Prostate | BPH | 1.59e-32 | -5.65e-01 | 0.0791 |
1973 | EIF4A1 | 048752_1579-all-cells | Human | Prostate | BPH | 1.24e-41 | -5.25e-01 | 0.1008 |
1973 | EIF4A1 | 052095_1628-all-cells | Human | Prostate | BPH | 2.62e-54 | -6.27e-01 | 0.1032 |
1973 | EIF4A1 | 052097_1595-all-cells | Human | Prostate | BPH | 5.59e-37 | -4.61e-01 | 0.0972 |
1973 | EIF4A1 | 052099_1652-all-cells | Human | Prostate | BPH | 2.27e-53 | -6.47e-01 | 0.1038 |
1973 | EIF4A1 | Dong_P1 | Human | Prostate | Tumor | 1.14e-143 | -1.06e+00 | 0.035 |
1973 | EIF4A1 | Dong_P3 | Human | Prostate | Tumor | 2.08e-78 | -9.79e-01 | 0.0278 |
1973 | EIF4A1 | Dong_P4 | Human | Prostate | Tumor | 7.10e-30 | -7.62e-01 | 0.0292 |
1973 | EIF4A1 | Dong_P5 | Human | Prostate | Tumor | 6.20e-131 | -1.11e+00 | 0.053 |
Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/EIF4A1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/EIF4A1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/EIF4A1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/EIF4A1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/EIF4A1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/EIF4A1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/EIF4A1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/EIF4A1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/EIF4A1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/EIF4A1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/EIF4A1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF4A1 | SNV | Missense_Mutation | novel | c.997N>T | p.Ala333Ser | p.A333S | P60842 | protein_coding | deleterious(0.04) | benign(0.266) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
EIF4A1 | SNV | Missense_Mutation | novel | c.706G>T | p.Val236Phe | p.V236F | P60842 | protein_coding | deleterious(0.02) | possibly_damaging(0.57) | TCGA-A2-A25E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
EIF4A1 | deletion | Frame_Shift_Del | novel | c.803delN | p.Thr269ProfsTer2 | p.T269Pfs*2 | P60842 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
EIF4A1 | deletion | Frame_Shift_Del | novel | c.1141_1142delNN | p.Lys381GlufsTer7 | p.K381Efs*7 | P60842 | protein_coding | | | TCGA-JL-A3YW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF4A1 | SNV | Missense_Mutation | novel | c.385N>A | p.Ala129Thr | p.A129T | P60842 | protein_coding | deleterious(0.02) | benign(0.364) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EIF4A1 | SNV | Missense_Mutation | | c.638C>T | p.Ser213Leu | p.S213L | P60842 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EIF4A1 | SNV | Missense_Mutation | novel | c.478G>A | p.Gly160Ser | p.G160S | P60842 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-JW-A5VI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | topotecan | PD |
EIF4A1 | SNV | Missense_Mutation | | c.233C>A | p.Ser78Tyr | p.S78Y | P60842 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EIF4A1 | SNV | Missense_Mutation | novel | c.932G>A | p.Arg311Gln | p.R311Q | P60842 | protein_coding | deleterious(0.02) | probably_damaging(0.965) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EIF4A1 | SNV | Missense_Mutation | rs865904208 | c.697N>T | p.Arg233Trp | p.R233W | P60842 | protein_coding | deleterious(0.03) | benign(0.075) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |