Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: COX14

Gene summary for COX14

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

COX14

Gene ID

84987

Gene namecytochrome c oxidase assembly factor COX14
Gene AliasC12orf62
Cytomap12q13.12
Gene Typeprotein-coding
GO ID

GO:0006996

UniProtAcc

Q96I36


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
84987COX14PTC01HumanThyroidPTC7.69e-031.38e-010.1899
84987COX14PTC05HumanThyroidPTC2.10e-109.12e-010.2065
84987COX14PTC06HumanThyroidPTC1.05e-199.23e-010.2057
84987COX14PTC07HumanThyroidPTC3.39e-308.33e-010.2044
84987COX14ATC08HumanThyroidATC2.44e-05-5.40e-010.0541
84987COX14ATC12HumanThyroidATC7.39e-109.80e-020.34
84987COX14ATC13HumanThyroidATC8.42e-074.27e-010.34
84987COX14ATC3HumanThyroidATC4.65e-06-2.93e-010.338
84987COX14ATC4HumanThyroidATC1.35e-092.92e-010.34
84987COX14ATC5HumanThyroidATC1.16e-105.19e-010.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00331089CervixCCmitochondrial respiratory chain complex assembly26/231193/187233.97e-056.18e-0426
GO:0033108ColorectumADmitochondrial respiratory chain complex assembly46/391893/187238.95e-106.91e-0846
GO:00331081ColorectumSERmitochondrial respiratory chain complex assembly39/289793/187238.13e-108.74e-0839
GO:00331082ColorectumMSSmitochondrial respiratory chain complex assembly44/346793/187232.17e-102.09e-0844
GO:00331083ColorectumMSI-Hmitochondrial respiratory chain complex assembly30/131993/187235.71e-131.27e-1030
GO:003310810EndometriumAEHmitochondrial respiratory chain complex assembly30/210093/187234.63e-082.50e-0630
GO:003310815EndometriumEECmitochondrial respiratory chain complex assembly31/216893/187232.46e-081.45e-0631
GO:003310820EsophagusHGINmitochondrial respiratory chain complex assembly47/258793/187233.15e-178.60e-1547
GO:00170044EsophagusHGINcytochrome complex assembly18/258736/187232.39e-071.14e-0518
GO:00336173EsophagusHGINmitochondrial cytochrome c oxidase assembly13/258722/187239.51e-073.80e-0513
GO:00085353EsophagusHGINrespiratory chain complex IV assembly14/258726/187231.68e-066.29e-0514
GO:0033108110EsophagusESCCmitochondrial respiratory chain complex assembly83/855293/187239.56e-191.05e-1683
GO:001700413EsophagusESCCcytochrome complex assembly34/855236/187235.08e-101.31e-0834
GO:000853512EsophagusESCCrespiratory chain complex IV assembly24/855226/187236.87e-078.99e-0624
GO:003361712EsophagusESCCmitochondrial cytochrome c oxidase assembly21/855222/187238.75e-071.13e-0521
GO:00331087LiverCirrhoticmitochondrial respiratory chain complex assembly64/463493/187233.85e-197.79e-1764
GO:0017004LiverCirrhoticcytochrome complex assembly22/463436/187233.92e-066.70e-0522
GO:0033617LiverCirrhoticmitochondrial cytochrome c oxidase assembly14/463422/187231.27e-041.25e-0314
GO:0008535LiverCirrhoticrespiratory chain complex IV assembly15/463426/187233.43e-042.93e-0315
GO:003310812LiverHCCmitochondrial respiratory chain complex assembly80/795893/187233.47e-184.15e-1680
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0471420CervixCCThermogenesis76/1267232/84654.29e-121.16e-106.85e-1176
hsa04714110CervixCCThermogenesis76/1267232/84654.29e-121.16e-106.85e-1176
hsa04714ColorectumADThermogenesis120/2092232/84652.76e-191.16e-177.37e-18120
hsa047141ColorectumADThermogenesis120/2092232/84652.76e-191.16e-177.37e-18120
hsa047142ColorectumSERThermogenesis106/1580232/84651.15e-216.34e-204.61e-20106
hsa047143ColorectumSERThermogenesis106/1580232/84651.15e-216.34e-204.61e-20106
hsa047144ColorectumMSSThermogenesis113/1875232/84651.52e-194.62e-182.83e-18113
hsa047145ColorectumMSSThermogenesis113/1875232/84651.52e-194.62e-182.83e-18113
hsa047146ColorectumMSI-HThermogenesis56/797232/84651.79e-114.14e-103.47e-1056
hsa047147ColorectumMSI-HThermogenesis56/797232/84651.79e-114.14e-103.47e-1056
hsa0471426EndometriumAEHThermogenesis85/1197232/84653.44e-189.33e-176.83e-1785
hsa04714111EndometriumAEHThermogenesis85/1197232/84653.44e-189.33e-176.83e-1785
hsa0471427EndometriumEECThermogenesis85/1237232/84652.79e-177.05e-165.26e-1685
hsa0471436EndometriumEECThermogenesis85/1237232/84652.79e-177.05e-165.26e-1685
hsa0471439EsophagusHGINThermogenesis91/1383232/84651.97e-175.36e-164.25e-1691
hsa04714114EsophagusHGINThermogenesis91/1383232/84651.97e-175.36e-164.25e-1691
hsa04714211EsophagusESCCThermogenesis163/4205232/84659.22e-111.14e-095.86e-10163
hsa04714310EsophagusESCCThermogenesis163/4205232/84659.22e-111.14e-095.86e-10163
hsa0471414LiverCirrhoticThermogenesis121/2530232/84655.70e-131.36e-118.36e-12121
hsa0471415LiverCirrhoticThermogenesis121/2530232/84655.70e-131.36e-118.36e-12121
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
COX14SNVMissense_Mutationrs368516862c.98N>Ap.Arg33Glnp.R33QQ96I36protein_codingtolerated(0.07)possibly_damaging(0.572)TCGA-T2-A6X2-01Oral cavityhead & neck squamous cell carcinomaMale>=65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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