Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: AKR1A1

Gene summary for AKR1A1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

AKR1A1

Gene ID

10327

Gene namealdo-keto reductase family 1 member A1
Gene AliasALDR1
Cytomap1p34.1
Gene Typeprotein-coding
GO ID

GO:0005975

UniProtAcc

P14550


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10327AKR1A1male-WTAHumanThyroidPTC5.32e-462.86e-010.1037
10327AKR1A1PTC01HumanThyroidPTC4.63e-134.51e-010.1899
10327AKR1A1PTC03HumanThyroidPTC7.12e-032.68e-010.1784
10327AKR1A1PTC04HumanThyroidPTC1.23e-094.13e-010.1927
10327AKR1A1PTC05HumanThyroidPTC3.85e-291.10e+000.2065
10327AKR1A1PTC06HumanThyroidPTC7.92e-401.01e+000.2057
10327AKR1A1PTC07HumanThyroidPTC8.43e-519.57e-010.2044
10327AKR1A1ATC09HumanThyroidATC4.07e-081.36e-010.2871
10327AKR1A1ATC11HumanThyroidATC2.75e-077.68e-010.3386
10327AKR1A1ATC12HumanThyroidATC2.56e-142.73e-010.34
10327AKR1A1ATC13HumanThyroidATC1.52e-601.44e+000.34
10327AKR1A1ATC1HumanThyroidATC1.24e-091.08e-010.2878
10327AKR1A1ATC2HumanThyroidATC5.11e-151.37e+000.34
10327AKR1A1ATC3HumanThyroidATC7.38e-086.66e-010.338
10327AKR1A1ATC4HumanThyroidATC1.52e-214.66e-010.34
10327AKR1A1ATC5HumanThyroidATC7.07e-561.54e+000.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00987543ColorectumMSI-Hdetoxification23/1319152/187234.07e-049.06e-0323
GO:00060662ColorectumMSSalcohol metabolic process92/3467353/187232.57e-043.46e-0392
GO:00442822ColorectumMSSsmall molecule catabolic process94/3467376/187239.85e-049.86e-0394
GO:00193182ColorectumMSShexose metabolic process63/3467237/187231.32e-031.25e-0263
GO:00972372ColorectumMSScellular response to toxic substance37/3467124/187231.47e-031.36e-0237
GO:00067902ColorectumMSSsulfur compound metabolic process85/3467339/187231.52e-031.39e-0285
GO:00060811ColorectumMSScellular aldehyde metabolic process21/346760/187231.81e-031.60e-0221
GO:00059962ColorectumMSSmonosaccharide metabolic process66/3467257/187232.61e-032.06e-0266
GO:19907482ColorectumMSScellular detoxification34/3467116/187233.08e-032.34e-0234
GO:00723292ColorectumMSSmonocarboxylic acid catabolic process35/3467122/187233.97e-032.90e-0235
GO:00160542ColorectumMSSorganic acid catabolic process61/3467240/187234.72e-033.31e-0261
GO:00060062ColorectumMSSglucose metabolic process51/3467196/187235.67e-033.85e-0251
GO:00987542ColorectumMSSdetoxification41/3467152/187236.41e-034.27e-0241
GO:0046394ColorectumMSScarboxylic acid biosynthetic process76/3467314/187236.71e-034.38e-0276
GO:0016053ColorectumMSSorganic acid biosynthetic process76/3467316/187237.88e-034.84e-0276
GO:00229003ColorectumMSI-Helectron transport chain52/1319175/187231.13e-195.21e-1752
GO:00060913ColorectumMSI-Hgeneration of precursor metabolites and energy93/1319490/187237.35e-193.14e-1693
GO:00060812ColorectumMSI-Hcellular aldehyde metabolic process13/131960/187232.27e-045.94e-0313
GO:00723293ColorectumFAPmonocarboxylic acid catabolic process32/2622122/187232.57e-043.53e-0332
GO:00060663ColorectumFAPalcohol metabolic process69/2622353/187232.29e-031.85e-0269
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa00620ColorectumADPyruvate metabolism28/209247/84653.71e-075.41e-063.45e-0628
hsa005613ColorectumMSSGlycerolipid metabolism23/187563/84656.55e-032.64e-021.62e-0223
hsa000105ColorectumMSSGlycolysis / Gluconeogenesis28/187567/84652.36e-041.81e-031.11e-0328
hsa006205ColorectumMSSPyruvate metabolism24/187547/84651.25e-051.35e-048.27e-0524
hsa052085ColorectumMSSChemical carcinogenesis - reactive oxygen species118/1875223/84652.71e-244.54e-222.78e-22118
hsa005612ColorectumMSSGlycerolipid metabolism23/187563/84656.55e-032.64e-021.62e-0223
hsa000104ColorectumMSSGlycolysis / Gluconeogenesis28/187567/84652.36e-041.81e-031.11e-0328
hsa006204ColorectumMSSPyruvate metabolism24/187547/84651.25e-051.35e-048.27e-0524
hsa052084ColorectumMSSChemical carcinogenesis - reactive oxygen species118/1875223/84652.71e-244.54e-222.78e-22118
hsa000103ColorectumSERGlycolysis / Gluconeogenesis24/158067/84656.62e-045.36e-033.89e-0324
hsa006203ColorectumSERPyruvate metabolism22/158047/84659.62e-061.33e-049.67e-0522
hsa000102ColorectumSERGlycolysis / Gluconeogenesis24/158067/84656.62e-045.36e-033.89e-0324
hsa006202ColorectumSERPyruvate metabolism22/158047/84659.62e-061.33e-049.67e-0522
hsa005611ColorectumADGlycerolipid metabolism24/209263/84651.25e-024.54e-022.90e-0224
hsa000101ColorectumADGlycolysis / Gluconeogenesis34/209267/84653.63e-064.34e-052.77e-0534
hsa006201ColorectumADPyruvate metabolism28/209247/84653.71e-075.41e-063.45e-0628
hsa052081ColorectumADChemical carcinogenesis - reactive oxygen species126/2092223/84651.01e-241.68e-221.07e-22126
hsa00561ColorectumADGlycerolipid metabolism24/209263/84651.25e-024.54e-022.90e-0224
hsa00010ColorectumADGlycolysis / Gluconeogenesis34/209267/84653.63e-064.34e-052.77e-0534
hsa05208ColorectumADChemical carcinogenesis - reactive oxygen species126/2092223/84651.01e-241.68e-221.07e-22126
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
AKR1A1M2MACCervixADJPRDX1,CAPG,TMEM176B, etc.2.00e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
AKR1A1MASTCervixADJPRDX1,CAPG,TMEM176B, etc.2.57e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
AKR1A1M2MACCervixHSIL_HPVPRDX1,CAPG,TMEM176B, etc.1.60e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
AKR1A1M2MACEndometriumADJCD81,PRDX1,CAPG, etc.2.90e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
AKR1A1M2MACEndometriumAEHCD81,PRDX1,CAPG, etc.2.73e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
AKR1A1M2MACEndometriumEECCD81,PRDX1,CAPG, etc.3.82e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
AKR1A1M2MACEndometriumHealthyCD81,PRDX1,CAPG, etc.4.34e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
AKR1A1cDCSkinADJPRDX1,HLA-DQB2,FCGBP, etc.5.26e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
AKR1A1LCSkinADJPRDX1,HLA-DQB2,FCGBP, etc.4.18e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
AKR1A1M2MACSkinADJPRDX1,HLA-DQB2,FCGBP, etc.2.06e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
AKR1A1SNVMissense_Mutationnovelc.631N>Tp.Ser211Cysp.S211CP14550protein_codingdeleterious(0.05)probably_damaging(0.996)TCGA-S3-AA0Z-01Breastbreast invasive carcinomaFemale<65I/IIAncillaryneulastaCR
AKR1A1deletionFrame_Shift_Delnovelc.945delGp.His316IlefsTer24p.H316Ifs*24P14550protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
AKR1A1SNVMissense_Mutationrs767717870c.106G>Ap.Ala36Thrp.A36TP14550protein_codingdeleterious(0.01)probably_damaging(0.977)TCGA-DS-A1OB-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycarboplatinPD
AKR1A1SNVMissense_Mutationnovelc.733C>Gp.Pro245Alap.P245AP14550protein_codingtolerated(0.2)benign(0.232)TCGA-DS-A1OB-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycarboplatinPD
AKR1A1SNVMissense_Mutationc.147C>Gp.Ile49Metp.I49MP14550protein_codingtolerated(0.05)benign(0.011)TCGA-EK-A2RA-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
AKR1A1SNVMissense_Mutationnovelc.107C>Tp.Ala36Valp.A36VP14550protein_codingdeleterious(0.01)probably_damaging(0.98)TCGA-AA-A00N-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
AKR1A1SNVMissense_Mutationnovelc.125N>Ap.Arg42Hisp.R42HP14550protein_codingdeleterious(0.01)probably_damaging(0.997)TCGA-AJ-A3EL-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
AKR1A1SNVMissense_Mutationrs757813969c.950C>Tp.Pro317Leup.P317LP14550protein_codingdeleterious(0)probably_damaging(0.989)TCGA-AP-A051-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
AKR1A1SNVMissense_Mutationnovelc.8N>Ap.Ala3Aspp.A3DP14550protein_codingdeleterious(0)benign(0.034)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
AKR1A1SNVMissense_Mutationnovelc.825N>Tp.Lys275Asnp.K275NP14550protein_codingtolerated(0.27)benign(0.001)TCGA-AP-A1DV-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
10327AKR1A1ENZYME, DRUGGABLE GENOMEdoxorubicinDOXORUBICIN21048526
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