![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: VAPA |
Gene summary for VAPA |
![]() |
Gene information | Species | Human | Gene symbol | VAPA | Gene ID | 9218 |
Gene name | VAMP associated protein A | |
Gene Alias | VAMP-A | |
Cytomap | 18p11.22 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9P0L0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9218 | VAPA | Dong_P1 | Human | Prostate | Tumor | 4.75e-32 | -9.52e-02 | 0.035 |
9218 | VAPA | Dong_P3 | Human | Prostate | Tumor | 6.54e-14 | -7.06e-02 | 0.0278 |
9218 | VAPA | Dong_P4 | Human | Prostate | Tumor | 8.01e-07 | 3.59e-02 | 0.0292 |
9218 | VAPA | Dong_P5 | Human | Prostate | Tumor | 1.90e-22 | -6.07e-02 | 0.053 |
9218 | VAPA | P10 | Human | Prostate | Tumor | 2.33e-03 | 1.98e-01 | -0.0902 |
9218 | VAPA | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 3.83e-03 | -4.07e-01 | 0.1602 |
9218 | VAPA | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 1.79e-12 | -5.18e-01 | 0.1575 |
9218 | VAPA | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 9.83e-24 | -5.81e-01 | 0.1545 |
9218 | VAPA | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 4.73e-15 | -6.20e-01 | 0.1569 |
9218 | VAPA | GSM5353247_PA_PR5269_3_S27_L002 | Human | Prostate | Tumor | 2.53e-02 | -9.21e-01 | 0.1532 |
9218 | VAPA | P2_S3_AK | Human | Skin | AK | 6.00e-07 | -2.06e-01 | -0.3287 |
9218 | VAPA | P4_S8_cSCC | Human | Skin | cSCC | 1.24e-17 | 1.88e-02 | -0.3095 |
9218 | VAPA | P5_S10_cSCC | Human | Skin | cSCC | 3.26e-24 | -1.96e-01 | -0.299 |
9218 | VAPA | P1_cSCC | Human | Skin | cSCC | 1.36e-52 | 1.98e+00 | 0.0292 |
9218 | VAPA | P2_cSCC | Human | Skin | cSCC | 2.57e-41 | 1.15e+00 | -0.024 |
9218 | VAPA | P4_cSCC | Human | Skin | cSCC | 3.24e-52 | 1.41e+00 | -0.00290000000000005 |
9218 | VAPA | P10_cSCC | Human | Skin | cSCC | 3.59e-52 | 2.17e+00 | 0.1017 |
9218 | VAPA | cSCC_p1 | Human | Skin | cSCC | 3.14e-05 | 2.53e-01 | -0.1916 |
9218 | VAPA | cSCC_p11 | Human | Skin | cSCC | 1.42e-03 | -6.65e-02 | -0.2102 |
9218 | VAPA | cSCC_p3 | Human | Skin | cSCC | 1.01e-05 | -4.73e-01 | -0.2085 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00190589 | Breast | Precancer | viral life cycle | 47/1080 | 317/18723 | 2.42e-09 | 1.99e-07 | 47 |
GO:00444039 | Breast | Precancer | biological process involved in symbiotic interaction | 42/1080 | 290/18723 | 3.40e-08 | 2.11e-06 | 42 |
GO:00521269 | Breast | Precancer | movement in host environment | 29/1080 | 175/18723 | 2.59e-07 | 1.28e-05 | 29 |
GO:00517019 | Breast | Precancer | biological process involved in interaction with host | 31/1080 | 203/18723 | 6.52e-07 | 2.71e-05 | 31 |
GO:00507929 | Breast | Precancer | regulation of viral process | 27/1080 | 164/18723 | 7.59e-07 | 3.05e-05 | 27 |
GO:00190799 | Breast | Precancer | viral genome replication | 22/1080 | 131/18723 | 5.63e-06 | 1.66e-04 | 22 |
GO:00439039 | Breast | Precancer | regulation of biological process involved in symbiotic interaction | 15/1080 | 72/18723 | 1.23e-05 | 3.17e-04 | 15 |
GO:19039009 | Breast | Precancer | regulation of viral life cycle | 23/1080 | 148/18723 | 1.31e-05 | 3.30e-04 | 23 |
GO:00709725 | Breast | Precancer | protein localization to endoplasmic reticulum | 15/1080 | 74/18723 | 1.74e-05 | 4.17e-04 | 15 |
GO:00069009 | Breast | Precancer | vesicle budding from membrane | 12/1080 | 61/18723 | 1.61e-04 | 2.69e-03 | 12 |
GO:00485249 | Breast | Precancer | positive regulation of viral process | 12/1080 | 65/18723 | 3.00e-04 | 4.34e-03 | 12 |
GO:19039026 | Breast | Precancer | positive regulation of viral life cycle | 6/1080 | 29/18723 | 5.49e-03 | 4.01e-02 | 6 |
GO:00072496 | Breast | Precancer | I-kappaB kinase/NF-kappaB signaling | 27/1080 | 281/18723 | 6.58e-03 | 4.53e-02 | 27 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
GO:001907914 | Breast | IDC | viral genome replication | 32/1434 | 131/18723 | 2.82e-09 | 2.46e-07 | 32 |
GO:004440314 | Breast | IDC | biological process involved in symbiotic interaction | 52/1434 | 290/18723 | 6.55e-09 | 5.03e-07 | 52 |
GO:005079214 | Breast | IDC | regulation of viral process | 36/1434 | 164/18723 | 6.55e-09 | 5.03e-07 | 36 |
GO:190390014 | Breast | IDC | regulation of viral life cycle | 30/1434 | 148/18723 | 7.25e-07 | 3.35e-05 | 30 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049792 | Liver | Cirrhotic | Cholesterol metabolism | 30/2530 | 51/8465 | 1.59e-05 | 1.39e-04 | 8.60e-05 | 30 |
hsa049793 | Liver | Cirrhotic | Cholesterol metabolism | 30/2530 | 51/8465 | 1.59e-05 | 1.39e-04 | 8.60e-05 | 30 |
hsa049794 | Liver | HCC | Cholesterol metabolism | 41/4020 | 51/8465 | 1.33e-06 | 1.35e-05 | 7.49e-06 | 41 |
hsa049795 | Liver | HCC | Cholesterol metabolism | 41/4020 | 51/8465 | 1.33e-06 | 1.35e-05 | 7.49e-06 | 41 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VAPA | SNV | Missense_Mutation | rs376344309 | c.782N>T | p.Ser261Leu | p.S261L | Q9P0L0 | protein_coding | tolerated(0.22) | benign(0.306) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VAPA | SNV | Missense_Mutation | c.757C>G | p.His253Asp | p.H253D | Q9P0L0 | protein_coding | tolerated(0.41) | possibly_damaging(0.6) | TCGA-GM-A2DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
VAPA | SNV | Missense_Mutation | rs773854854 | c.743T>C | p.Leu248Pro | p.L248P | Q9P0L0 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
VAPA | SNV | Missense_Mutation | c.128N>T | p.Ser43Leu | p.S43L | Q9P0L0 | protein_coding | deleterious(0.04) | probably_damaging(0.968) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
VAPA | SNV | Missense_Mutation | novel | c.194N>A | p.Ser65Asn | p.S65N | Q9P0L0 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VAPA | deletion | Frame_Shift_Del | c.348delN | p.Lys117AsnfsTer5 | p.K117Nfs*5 | Q9P0L0 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
VAPA | SNV | Missense_Mutation | c.763N>A | p.Asp255Asn | p.D255N | Q9P0L0 | protein_coding | tolerated(0.29) | possibly_damaging(0.526) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
VAPA | SNV | Missense_Mutation | novel | c.248T>C | p.Phe83Ser | p.F83S | Q9P0L0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VAPA | SNV | Missense_Mutation | novel | c.461G>A | p.Ser154Asn | p.S154N | Q9P0L0 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VAPA | SNV | Missense_Mutation | rs773084616 | c.560N>C | p.Met187Thr | p.M187T | Q9P0L0 | protein_coding | deleterious(0.04) | benign(0.046) | TCGA-B5-A0JT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Hormone Therapy | megace | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |