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Gene: TSPAN3 |
Gene summary for TSPAN3 |
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Gene information | Species | Human | Gene symbol | TSPAN3 | Gene ID | 10099 |
Gene name | tetraspanin 3 | |
Gene Alias | TM4-A | |
Cytomap | 15q24.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | O60637 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10099 | TSPAN3 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 3.41e-13 | 6.91e-01 | -0.1972 |
10099 | TSPAN3 | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 8.63e-05 | 3.14e-01 | -0.2126 |
10099 | TSPAN3 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 1.72e-03 | 7.78e-01 | -0.2027 |
10099 | TSPAN3 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 7.99e-25 | 1.37e+00 | -0.1833 |
10099 | TSPAN3 | 047563_1562-all-cells | Human | Prostate | BPH | 3.86e-08 | -1.22e-01 | 0.0791 |
10099 | TSPAN3 | Dong_P1 | Human | Prostate | Tumor | 3.37e-30 | 3.25e-01 | 0.035 |
10099 | TSPAN3 | Dong_P3 | Human | Prostate | Tumor | 1.36e-14 | 5.76e-02 | 0.0278 |
10099 | TSPAN3 | Dong_P4 | Human | Prostate | Tumor | 6.67e-07 | 4.29e-01 | 0.0292 |
10099 | TSPAN3 | Dong_P5 | Human | Prostate | Tumor | 1.62e-34 | 9.41e-02 | 0.053 |
10099 | TSPAN3 | P9 | Human | Prostate | Tumor | 1.25e-02 | -3.18e-01 | -0.0285 |
10099 | TSPAN3 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 3.42e-05 | 5.78e-01 | 0.1557 |
10099 | TSPAN3 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 2.45e-02 | 4.39e-01 | 0.1633 |
10099 | TSPAN3 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 1.53e-06 | 3.81e-01 | 0.1602 |
10099 | TSPAN3 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 3.09e-04 | 5.32e-01 | 0.1608 |
10099 | TSPAN3 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 9.25e-11 | 1.76e-01 | 0.1545 |
10099 | TSPAN3 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 4.85e-03 | 6.88e-02 | 0.1569 |
10099 | TSPAN3 | GSM5353247_PA_PR5269_3_S27_L002 | Human | Prostate | Tumor | 3.86e-02 | 3.34e-01 | 0.1532 |
10099 | TSPAN3 | P4_S8_cSCC | Human | Skin | cSCC | 1.93e-04 | 1.07e-01 | -0.3095 |
10099 | TSPAN3 | P5_S10_cSCC | Human | Skin | cSCC | 1.15e-06 | 1.56e-01 | -0.299 |
10099 | TSPAN3 | P1_cSCC | Human | Skin | cSCC | 3.05e-20 | 7.86e-01 | 0.0292 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265921 | Liver | HCC | protein localization to plasma membrane | 177/7958 | 284/18723 | 1.02e-11 | 4.18e-10 | 177 |
GO:199077821 | Liver | HCC | protein localization to cell periphery | 200/7958 | 333/18723 | 6.07e-11 | 2.23e-09 | 200 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:00469311 | Liver | HCC | pore complex assembly | 17/7958 | 20/18723 | 1.18e-04 | 9.87e-04 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSPAN3 | SNV | Missense_Mutation | c.390N>A | p.Asn130Lys | p.N130K | O60637 | protein_coding | deleterious(0.03) | benign(0.142) | TCGA-E9-A1NF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
TSPAN3 | SNV | Missense_Mutation | c.239G>A | p.Arg80His | p.R80H | O60637 | protein_coding | tolerated(0.1) | benign(0.12) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TSPAN3 | SNV | Missense_Mutation | rs376931567 | c.238C>T | p.Arg80Cys | p.R80C | O60637 | protein_coding | tolerated(0.16) | benign(0.082) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
TSPAN3 | SNV | Missense_Mutation | rs749142832 | c.748N>A | p.Gly250Arg | p.G250R | O60637 | protein_coding | deleterious_low_confidence(0) | benign(0.312) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TSPAN3 | SNV | Missense_Mutation | novel | c.104T>G | p.Phe35Cys | p.F35C | O60637 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSPAN3 | SNV | Missense_Mutation | novel | c.353N>A | p.Ser118Asn | p.S118N | O60637 | protein_coding | tolerated(0.09) | benign(0.015) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
TSPAN3 | SNV | Missense_Mutation | c.415G>T | p.Asp139Tyr | p.D139Y | O60637 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TSPAN3 | SNV | Missense_Mutation | rs375306231 | c.350N>A | p.Arg117His | p.R117H | O60637 | protein_coding | tolerated(0.57) | benign(0.005) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TSPAN3 | SNV | Missense_Mutation | c.257T>C | p.Phe86Ser | p.F86S | O60637 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TSPAN3 | SNV | Missense_Mutation | c.257N>A | p.Phe86Tyr | p.F86Y | O60637 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-55-1594-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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