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Gene: SHFM1 |
Gene summary for SHFM1 |
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Gene information | Species | Human | Gene symbol | SHFM1 | Gene ID | 7979 |
Gene name | SEM1 26S proteasome subunit | |
Gene Alias | C7orf76 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | P60896 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7979 | SHFM1 | C30 | Human | Oral cavity | OSCC | 6.61e-61 | 4.44e+00 | 0.3055 |
7979 | SHFM1 | C38 | Human | Oral cavity | OSCC | 1.05e-33 | 3.78e+00 | 0.172 |
7979 | SHFM1 | C43 | Human | Oral cavity | OSCC | 4.90e-117 | 2.56e+00 | 0.1704 |
7979 | SHFM1 | C46 | Human | Oral cavity | OSCC | 4.45e-87 | 2.41e+00 | 0.1673 |
7979 | SHFM1 | C51 | Human | Oral cavity | OSCC | 9.26e-46 | 3.61e+00 | 0.2674 |
7979 | SHFM1 | C57 | Human | Oral cavity | OSCC | 2.76e-56 | 2.57e+00 | 0.1679 |
7979 | SHFM1 | C06 | Human | Oral cavity | OSCC | 2.36e-25 | 4.03e+00 | 0.2699 |
7979 | SHFM1 | C07 | Human | Oral cavity | OSCC | 7.02e-20 | 3.52e+00 | 0.2491 |
7979 | SHFM1 | C08 | Human | Oral cavity | OSCC | 1.09e-118 | 3.31e+00 | 0.1919 |
7979 | SHFM1 | C86 | Human | Oral cavity | OSCC | 1.33e-06 | 1.44e+00 | 0.161 |
7979 | SHFM1 | C09 | Human | Oral cavity | OSCC | 1.46e-52 | 1.83e+00 | 0.1431 |
7979 | SHFM1 | LN22 | Human | Oral cavity | OSCC | 1.60e-38 | 3.30e+00 | 0.1733 |
7979 | SHFM1 | LN38 | Human | Oral cavity | OSCC | 3.07e-26 | 3.16e+00 | 0.168 |
7979 | SHFM1 | LN46 | Human | Oral cavity | OSCC | 1.43e-43 | 2.51e+00 | 0.1666 |
7979 | SHFM1 | LP15 | Human | Oral cavity | LP | 1.18e-25 | 3.67e+00 | 0.2174 |
7979 | SHFM1 | LP16 | Human | Oral cavity | LP | 1.26e-02 | 1.86e+00 | 0.1055 |
7979 | SHFM1 | LP17 | Human | Oral cavity | LP | 2.44e-16 | 3.25e+00 | 0.2349 |
7979 | SHFM1 | EOLP-1 | Human | Oral cavity | EOLP | 7.39e-19 | -5.31e-01 | -0.0202 |
7979 | SHFM1 | EOLP-2 | Human | Oral cavity | EOLP | 1.05e-16 | -5.31e-01 | -0.0203 |
7979 | SHFM1 | NEOLP-1 | Human | Oral cavity | NEOLP | 3.89e-18 | -5.31e-01 | -0.0194 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0305010 | Breast | Precancer | Proteasome | 25/684 | 46/8465 | 4.35e-16 | 9.81e-15 | 7.52e-15 | 25 |
hsa0501714 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa0516918 | Breast | Precancer | Epstein-Barr virus infection | 35/684 | 202/8465 | 1.15e-05 | 1.26e-04 | 9.64e-05 | 35 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0305013 | Breast | Precancer | Proteasome | 25/684 | 46/8465 | 4.35e-16 | 9.81e-15 | 7.52e-15 | 25 |
hsa0501715 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa0516919 | Breast | Precancer | Epstein-Barr virus infection | 35/684 | 202/8465 | 1.15e-05 | 1.26e-04 | 9.64e-05 | 35 |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502023 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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