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Gene: SET |
Gene summary for SET |
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Gene information | Species | Human | Gene symbol | SET | Gene ID | 6418 |
Gene name | SET nuclear proto-oncogene | |
Gene Alias | 2PP2A | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q01105 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6418 | SET | LN46 | Human | Oral cavity | OSCC | 2.94e-23 | 1.37e+00 | 0.1666 |
6418 | SET | LP15 | Human | Oral cavity | LP | 1.34e-12 | 2.04e+00 | 0.2174 |
6418 | SET | LP17 | Human | Oral cavity | LP | 4.24e-10 | 1.44e+00 | 0.2349 |
6418 | SET | EOLP-1 | Human | Oral cavity | EOLP | 1.84e-06 | -1.56e-01 | -0.0202 |
6418 | SET | NEOLP-2 | Human | Oral cavity | NEOLP | 1.70e-05 | -1.07e-01 | -0.0196 |
6418 | SET | NEOLP-3 | Human | Oral cavity | NEOLP | 1.24e-05 | -6.78e-03 | -0.0191 |
6418 | SET | SYSMH1 | Human | Oral cavity | OSCC | 1.17e-32 | 1.59e+00 | 0.1127 |
6418 | SET | SYSMH2 | Human | Oral cavity | OSCC | 5.96e-32 | 2.41e+00 | 0.2326 |
6418 | SET | SYSMH3 | Human | Oral cavity | OSCC | 4.67e-38 | 2.47e+00 | 0.2442 |
6418 | SET | SYSMH4 | Human | Oral cavity | OSCC | 2.91e-09 | 6.31e-01 | 0.1226 |
6418 | SET | SYSMH5 | Human | Oral cavity | OSCC | 8.52e-13 | 1.04e+00 | 0.0647 |
6418 | SET | SYSMH6 | Human | Oral cavity | OSCC | 1.59e-15 | 8.69e-01 | 0.1275 |
6418 | SET | GSM5252126_BPH283PrGF_Via | Human | Prostate | BPH | 1.27e-03 | 5.39e-03 | -0.1771 |
6418 | SET | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 5.08e-17 | 6.65e-01 | -0.1972 |
6418 | SET | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 4.69e-09 | 4.27e-01 | -0.2126 |
6418 | SET | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 1.03e-09 | 1.05e+00 | -0.2247 |
6418 | SET | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 2.68e-16 | 1.36e+00 | -0.2027 |
6418 | SET | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 2.17e-10 | 6.55e-01 | -0.1833 |
6418 | SET | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 1.94e-06 | 6.06e-01 | -0.23 |
6418 | SET | 047563_1562-all-cells | Human | Prostate | BPH | 4.45e-19 | -3.26e-01 | 0.0791 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
GO:19012149 | Breast | Precancer | regulation of neuron death | 41/1080 | 319/18723 | 1.27e-06 | 4.80e-05 | 41 |
GO:00435237 | Breast | Precancer | regulation of neuron apoptotic process | 31/1080 | 212/18723 | 1.69e-06 | 6.08e-05 | 31 |
GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
GO:00435243 | Breast | Precancer | negative regulation of neuron apoptotic process | 19/1080 | 145/18723 | 6.83e-04 | 8.34e-03 | 19 |
GO:00329865 | Breast | Precancer | protein-DNA complex disassembly | 6/1080 | 20/18723 | 6.99e-04 | 8.43e-03 | 6 |
GO:19012157 | Breast | Precancer | negative regulation of neuron death | 24/1080 | 208/18723 | 9.50e-04 | 1.07e-02 | 24 |
GO:007099714 | Breast | IDC | neuron death | 57/1434 | 361/18723 | 1.31e-07 | 7.38e-06 | 57 |
GO:005140213 | Breast | IDC | neuron apoptotic process | 42/1434 | 246/18723 | 7.21e-07 | 3.35e-05 | 42 |
GO:190121414 | Breast | IDC | regulation of neuron death | 48/1434 | 319/18723 | 5.01e-06 | 1.69e-04 | 48 |
GO:004352313 | Breast | IDC | regulation of neuron apoptotic process | 35/1434 | 212/18723 | 1.26e-05 | 3.29e-04 | 35 |
GO:000640113 | Breast | IDC | RNA catabolic process | 38/1434 | 278/18723 | 3.54e-04 | 5.16e-03 | 38 |
GO:004352411 | Breast | IDC | negative regulation of neuron apoptotic process | 23/1434 | 145/18723 | 6.58e-04 | 8.11e-03 | 23 |
GO:190121513 | Breast | IDC | negative regulation of neuron death | 29/1434 | 208/18723 | 1.23e-03 | 1.32e-02 | 29 |
GO:190136112 | Breast | IDC | organic cyclic compound catabolic process | 56/1434 | 495/18723 | 2.12e-03 | 1.99e-02 | 56 |
GO:004670012 | Breast | IDC | heterocycle catabolic process | 51/1434 | 445/18723 | 2.51e-03 | 2.25e-02 | 51 |
GO:003298612 | Breast | IDC | protein-DNA complex disassembly | 6/1434 | 20/18723 | 3.03e-03 | 2.60e-02 | 6 |
GO:003465513 | Breast | IDC | nucleobase-containing compound catabolic process | 47/1434 | 407/18723 | 3.12e-03 | 2.63e-02 | 47 |
GO:004427012 | Breast | IDC | cellular nitrogen compound catabolic process | 50/1434 | 451/18723 | 5.29e-03 | 3.93e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SET | SNV | Missense_Mutation | rs142648600 | c.548N>T | p.Ser183Leu | p.S183L | Q01105 | protein_coding | tolerated(0.16) | benign(0.11) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SET | SNV | Missense_Mutation | novel | c.270N>C | p.Lys90Asn | p.K90N | Q01105 | protein_coding | tolerated(0.05) | benign(0.16) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SET | SNV | Missense_Mutation | c.195N>C | p.Glu65Asp | p.E65D | Q01105 | protein_coding | deleterious(0.01) | possibly_damaging(0.651) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
SET | SNV | Missense_Mutation | novel | c.469N>A | p.His157Asn | p.H157N | Q01105 | protein_coding | tolerated(0.06) | benign(0.208) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
SET | SNV | Missense_Mutation | c.229C>T | p.Arg77Cys | p.R77C | Q01105 | protein_coding | tolerated(0.11) | benign(0.444) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SET | SNV | Missense_Mutation | c.572G>A | p.Ser191Asn | p.S191N | Q01105 | protein_coding | tolerated(0.16) | benign(0.029) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SET | SNV | Missense_Mutation | c.260N>C | p.Leu87Ser | p.L87S | Q01105 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SET | SNV | Missense_Mutation | c.508N>A | p.Glu170Lys | p.E170K | Q01105 | protein_coding | tolerated(0.18) | benign(0.086) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SET | deletion | Frame_Shift_Del | c.273delN | p.Pro92GlnfsTer5 | p.P92Qfs*5 | Q01105 | protein_coding | TCGA-CM-5862-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
SET | SNV | Missense_Mutation | novel | c.161N>C | p.Glu54Ala | p.E54A | Q01105 | protein_coding | tolerated(0.06) | possibly_damaging(0.893) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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