Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SENP6

Gene summary for SENP6

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SENP6

Gene ID

26054

Gene nameSUMO specific peptidase 6
Gene AliasSSP1
Cytomap6q14.1
Gene Typeprotein-coding
GO ID

GO:0000226

UniProtAcc

B3KMM0


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
26054SENP6Dong_P5HumanProstateTumor2.97e-21-2.83e-020.053
26054SENP6GSM5353215_PA_AUG_PB_1B_S2HumanProstateTumor1.56e-087.68e-010.1557
26054SENP6GSM5353216_PA_PB1A_Pool_1_3_S50_L002HumanProstateTumor8.85e-087.22e-010.159
26054SENP6GSM5353217_PA_PB1A_Pool_2_S107_L004HumanProstateTumor1.49e-026.81e-010.156
26054SENP6GSM5353220_PA_PB1B_Pool_3_S51_L002HumanProstateTumor1.68e-035.28e-010.1531
26054SENP6GSM5353221_PA_PB2A_Pool_1_3_S25_L001HumanProstateTumor2.62e-116.78e-010.1633
26054SENP6GSM5353222_PA_PB2B_Pool_1_3_S52_L002HumanProstateTumor1.12e-156.93e-010.1608
26054SENP6GSM5353223_PA_PB2B_Pool_2_S26_L001HumanProstateTumor6.43e-086.90e-010.1604
26054SENP6GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001HumanProstateTumor3.67e-106.85e-010.1621
26054SENP6GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002HumanProstateTumor3.80e-034.42e-010.1619
26054SENP6GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002HumanProstateTumor3.15e-106.13e-010.1602
26054SENP6GSM5353228_PA_PR5199-640K_Pool_1_3_S108_L004HumanProstateTumor1.43e-023.22e-010.1537
26054SENP6GSM5353236_PA_PR5251_T1_S7_L001HumanProstateTumor1.18e-086.54e-010.1608
26054SENP6GSM5353237_PA_PR5251_T2_S8_L001HumanProstateTumor6.90e-108.47e-010.1622
26054SENP6GSM5353240_PA_PR5254_T1_S15_L001HumanProstateTumor5.73e-104.53e-010.1575
26054SENP6GSM5353243_PA_PR5261_T1_S23_L002HumanProstateTumor9.51e-134.32e-010.1545
26054SENP6GSM5353244_PA_PR5261_T2_S24_L002HumanProstateTumor1.16e-073.67e-010.1569
26054SENP6GSM5353248_PA_PR5269_4_S28_L002HumanProstateTumor8.65e-054.77e-010.1541
26054SENP6P1_S1_AKHumanSkinAK5.76e-135.12e-01-0.3399
26054SENP6P2_S3_AKHumanSkinAK1.08e-103.60e-01-0.3287
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004325410CervixCCregulation of protein-containing complex assembly96/2311428/187232.91e-093.05e-0796
GO:19021153CervixCCregulation of organelle assembly40/2311186/187232.92e-043.15e-0340
GO:00705074CervixCCregulation of microtubule cytoskeleton organization32/2311148/187231.02e-038.51e-0332
GO:00182054CervixCCpeptidyl-lysine modification62/2311376/187231.04e-024.97e-0262
GO:0043254ColorectumADregulation of protein-containing complex assembly148/3918428/187232.64e-113.18e-09148
GO:0033044ColorectumADregulation of chromosome organization60/3918187/187232.25e-042.94e-0360
GO:0007051ColorectumADspindle organization58/3918184/187234.71e-045.20e-0358
GO:0051225ColorectumADspindle assembly37/3918117/187234.32e-032.96e-0237
GO:0070507ColorectumADregulation of microtubule cytoskeleton organization44/3918148/187237.05e-034.31e-0244
GO:0090169ColorectumADregulation of spindle assembly11/391825/187237.89e-034.73e-0211
GO:00432541ColorectumSERregulation of protein-containing complex assembly119/2897428/187233.34e-115.86e-09119
GO:00901691ColorectumSERregulation of spindle assembly10/289725/187232.70e-032.44e-0210
GO:0090224ColorectumSERregulation of spindle organization13/289739/187234.39e-033.51e-0213
GO:00432542ColorectumMSSregulation of protein-containing complex assembly130/3467428/187231.38e-091.03e-07130
GO:00330441ColorectumMSSregulation of chromosome organization55/3467187/187231.86e-042.63e-0355
GO:00070511ColorectumMSSspindle organization53/3467184/187234.23e-045.19e-0353
GO:00512251ColorectumMSSspindle assembly33/3467117/187236.68e-034.38e-0233
GO:00432544ColorectumFAPregulation of protein-containing complex assembly101/2622428/187235.18e-084.07e-06101
GO:00330442ColorectumFAPregulation of chromosome organization46/2622187/187237.41e-051.36e-0346
GO:00070512ColorectumFAPspindle organization41/2622184/187231.50e-031.34e-0241
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SENP6SNVMissense_Mutationc.1471C>Gp.Leu491Valp.L491VQ9GZR1protein_codingdeleterious(0)probably_damaging(0.996)TCGA-A2-A0YH-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycinSD
SENP6SNVMissense_Mutationrs550031341c.1316N>Tp.Ser439Phep.S439FQ9GZR1protein_codingdeleterious(0.01)possibly_damaging(0.45)TCGA-AC-A2B8-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapychemoPD
SENP6SNVMissense_Mutationnovelc.3139C>Tp.Leu1047Phep.L1047FQ9GZR1protein_codingtolerated(0.13)benign(0.051)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SENP6SNVMissense_Mutationnovelc.1543N>Gp.Gln515Glup.Q515EQ9GZR1protein_codingtolerated(0.3)benign(0.003)TCGA-BH-A0B6-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SENP6insertionFrame_Shift_Insnovelc.2597_2598insAGCTGGAATGCTGTGGCACAATCTCGGCTCACTGCAACCTCTGCCTCp.His866GlnfsTer50p.H866Qfs*50Q9GZR1protein_codingTCGA-A8-A07R-01Breastbreast invasive carcinomaFemale>=65III/IVAncillaryzoledronicSD
SENP6insertionIn_Frame_Insnovelc.2667_2668insTATGTTATTp.Lys889_Ser890insTyrValIlep.K889_S890insYVIQ9GZR1protein_codingTCGA-AR-A0U2-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapytamoxiphenPD
SENP6SNVMissense_Mutationc.1126N>Ap.Glu376Lysp.E376KQ9GZR1protein_codingtolerated(0.09)possibly_damaging(0.544)TCGA-C5-A901-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
SENP6SNVMissense_Mutationc.1276N>Gp.Gln426Glup.Q426EQ9GZR1protein_codingtolerated(0.08)benign(0.08)TCGA-DS-A0VM-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
SENP6SNVMissense_Mutationnovelc.1355N>Gp.Val452Glyp.V452GQ9GZR1protein_codingdeleterious(0)possibly_damaging(0.791)TCGA-MA-AA43-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
SENP6SNVMissense_Mutationnovelc.2254G>Cp.Glu752Glnp.E752QQ9GZR1protein_codingtolerated(0.91)benign(0.241)TCGA-VS-A9U6-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
26054SENP6ENZYME, PROTEASE, DRUGGABLE GENOMEGNF-PF-1702CHEMBL600313
26054SENP6ENZYME, PROTEASE, DRUGGABLE GENOMECID 4101591CHEMBL428789
26054SENP6ENZYME, PROTEASE, DRUGGABLE GENOMEDNDI1417156CHEMBL1504679
26054SENP6ENZYME, PROTEASE, DRUGGABLE GENOMEDIHYDROXANTHOHUMOLDIHYDROXANTHOHUMOL
26054SENP6ENZYME, PROTEASE, DRUGGABLE GENOMEIPRIFLAVONEIPRIFLAVONE
26054SENP6ENZYME, PROTEASE, DRUGGABLE GENOMEXANTHOANGELOL BXANTHOANGELOL B
26054SENP6ENZYME, PROTEASE, DRUGGABLE GENOME4-PHENYLAMINO-[1,2]NAPHTHOQUINONECHEMBL299853
26054SENP6ENZYME, PROTEASE, DRUGGABLE GENOME6,4'-DIHYDROXYFLAVONECHEMBL484663
26054SENP6ENZYME, PROTEASE, DRUGGABLE GENOME2-(4-NITROBENZYLSULFANYL)BENZOXAZOLECHEMBL412603
26054SENP6ENZYME, PROTEASE, DRUGGABLE GENOMEBAS-0338868CHEMBL378903
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