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Gene: S100A10 |
Gene summary for S100A10 |
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Gene information | Species | Human | Gene symbol | S100A10 | Gene ID | 6281 |
Gene name | S100 calcium binding protein A10 | |
Gene Alias | 42C | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P60903 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6281 | S100A10 | P126T-E | Human | Esophagus | ESCC | 3.30e-43 | 4.14e+00 | 0.1125 |
6281 | S100A10 | P127T-E | Human | Esophagus | ESCC | 5.21e-32 | 2.13e+00 | 0.0826 |
6281 | S100A10 | P128T-E | Human | Esophagus | ESCC | 5.30e-42 | 3.87e+00 | 0.1241 |
6281 | S100A10 | P130T-E | Human | Esophagus | ESCC | 9.89e-88 | 4.59e+00 | 0.1676 |
6281 | S100A10 | NAFLD1 | Human | Liver | NAFLD | 9.20e-05 | -1.31e+00 | -0.04 |
6281 | S100A10 | S41 | Human | Liver | Cirrhotic | 1.31e-09 | -1.12e+00 | -0.0343 |
6281 | S100A10 | S42 | Human | Liver | HCC | 3.20e-02 | -5.87e-01 | -0.0103 |
6281 | S100A10 | S43 | Human | Liver | Cirrhotic | 8.90e-48 | -1.18e+00 | -0.0187 |
6281 | S100A10 | HCC1_Meng | Human | Liver | HCC | 2.04e-72 | -1.94e-01 | 0.0246 |
6281 | S100A10 | HCC2_Meng | Human | Liver | HCC | 8.17e-25 | 4.95e-01 | 0.0107 |
6281 | S100A10 | cirrhotic1 | Human | Liver | Cirrhotic | 2.88e-27 | 1.98e-01 | 0.0202 |
6281 | S100A10 | cirrhotic2 | Human | Liver | Cirrhotic | 1.56e-25 | 7.93e-02 | 0.0201 |
6281 | S100A10 | cirrhotic3 | Human | Liver | Cirrhotic | 7.05e-24 | 5.59e-01 | 0.0215 |
6281 | S100A10 | p6 | Human | Liver | Cyst | 6.55e-16 | -1.31e+00 | -0.0218 |
6281 | S100A10 | HCC1 | Human | Liver | HCC | 3.03e-19 | 3.39e+00 | 0.5336 |
6281 | S100A10 | HCC2 | Human | Liver | HCC | 2.84e-24 | 5.55e+00 | 0.5341 |
6281 | S100A10 | HCC5 | Human | Liver | HCC | 9.97e-20 | 5.48e-01 | 0.4932 |
6281 | S100A10 | Pt13.a | Human | Liver | HCC | 2.23e-07 | -1.65e-01 | 0.021 |
6281 | S100A10 | Pt13.b | Human | Liver | HCC | 6.57e-32 | -3.89e-01 | 0.0251 |
6281 | S100A10 | Pt13.c | Human | Liver | HCC | 1.40e-10 | -7.08e-01 | 0.0076 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457859 | Breast | Precancer | positive regulation of cell adhesion | 52/1080 | 437/18723 | 5.74e-07 | 2.49e-05 | 52 |
GO:00510989 | Breast | Precancer | regulation of binding | 44/1080 | 363/18723 | 2.59e-06 | 8.65e-05 | 44 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00514959 | Breast | Precancer | positive regulation of cytoskeleton organization | 28/1080 | 226/18723 | 1.13e-04 | 2.04e-03 | 28 |
GO:00510999 | Breast | Precancer | positive regulation of binding | 23/1080 | 173/18723 | 1.58e-04 | 2.68e-03 | 23 |
GO:00069009 | Breast | Precancer | vesicle budding from membrane | 12/1080 | 61/18723 | 1.61e-04 | 2.69e-03 | 12 |
GO:00070159 | Breast | Precancer | actin filament organization | 44/1080 | 442/18723 | 3.02e-04 | 4.35e-03 | 44 |
GO:00094108 | Breast | Precancer | response to xenobiotic stimulus | 45/1080 | 462/18723 | 4.17e-04 | 5.56e-03 | 45 |
GO:01501174 | Breast | Precancer | positive regulation of cell-substrate junction organization | 8/1080 | 33/18723 | 4.55e-04 | 6.02e-03 | 8 |
GO:00329569 | Breast | Precancer | regulation of actin cytoskeleton organization | 36/1080 | 358/18723 | 8.56e-04 | 9.88e-03 | 36 |
GO:01100539 | Breast | Precancer | regulation of actin filament organization | 29/1080 | 278/18723 | 1.50e-03 | 1.55e-02 | 29 |
GO:19000268 | Breast | Precancer | positive regulation of substrate adhesion-dependent cell spreading | 8/1080 | 41/18723 | 2.08e-03 | 1.97e-02 | 8 |
GO:00514929 | Breast | Precancer | regulation of stress fiber assembly | 13/1080 | 91/18723 | 2.11e-03 | 2.00e-02 | 13 |
GO:00315794 | Breast | Precancer | membrane raft organization | 6/1080 | 25/18723 | 2.49e-03 | 2.28e-02 | 6 |
GO:00514965 | Breast | Precancer | positive regulation of stress fiber assembly | 9/1080 | 52/18723 | 2.67e-03 | 2.36e-02 | 9 |
GO:00322338 | Breast | Precancer | positive regulation of actin filament bundle assembly | 10/1080 | 63/18723 | 3.07e-03 | 2.62e-02 | 10 |
GO:00300389 | Breast | Precancer | contractile actin filament bundle assembly | 14/1080 | 106/18723 | 3.07e-03 | 2.62e-02 | 14 |
GO:00431499 | Breast | Precancer | stress fiber assembly | 14/1080 | 106/18723 | 3.07e-03 | 2.62e-02 | 14 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0513243 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0513253 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05132110 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa0513244 | Cervix | N_HPV | Salmonella infection | 28/349 | 249/8465 | 1.18e-06 | 1.64e-05 | 1.28e-05 | 28 |
hsa0513254 | Cervix | N_HPV | Salmonella infection | 28/349 | 249/8465 | 1.18e-06 | 1.64e-05 | 1.28e-05 | 28 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051322 | Colorectum | SER | Salmonella infection | 77/1580 | 249/8465 | 1.56e-06 | 2.35e-05 | 1.71e-05 | 77 |
hsa051323 | Colorectum | SER | Salmonella infection | 77/1580 | 249/8465 | 1.56e-06 | 2.35e-05 | 1.71e-05 | 77 |
hsa051324 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa051325 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa051326 | Colorectum | MSI-H | Salmonella infection | 43/797 | 249/8465 | 5.91e-05 | 8.33e-04 | 6.98e-04 | 43 |
hsa051327 | Colorectum | MSI-H | Salmonella infection | 43/797 | 249/8465 | 5.91e-05 | 8.33e-04 | 6.98e-04 | 43 |
hsa051328 | Colorectum | FAP | Salmonella infection | 67/1404 | 249/8465 | 2.04e-05 | 2.52e-04 | 1.53e-04 | 67 |
hsa051329 | Colorectum | FAP | Salmonella infection | 67/1404 | 249/8465 | 2.04e-05 | 2.52e-04 | 1.53e-04 | 67 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
S100A10 | SNV | Missense_Mutation | c.104N>G | p.Met35Arg | p.M35R | P60903 | protein_coding | deleterious(0.01) | benign(0.424) | TCGA-AR-A0TP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
S100A10 | SNV | Missense_Mutation | novel | c.224N>G | p.Leu75Arg | p.L75R | P60903 | protein_coding | deleterious(0.02) | probably_damaging(0.981) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A10 | SNV | Missense_Mutation | rs11542012 | c.230N>T | p.Ala77Val | p.A77V | P60903 | protein_coding | tolerated(0.3) | benign(0.104) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
S100A10 | SNV | Missense_Mutation | rs374528021 | c.211N>G | p.Ser71Gly | p.S71G | P60903 | protein_coding | tolerated(0.15) | benign(0.001) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
S100A10 | SNV | Missense_Mutation | novel | c.216C>A | p.Phe72Leu | p.F72L | P60903 | protein_coding | tolerated(0.1) | benign(0.132) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A10 | SNV | Missense_Mutation | novel | c.183N>T | p.Gln61His | p.Q61H | P60903 | protein_coding | deleterious(0.03) | benign(0.013) | TCGA-CV-6937-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
S100A10 | SNV | Missense_Mutation | novel | c.250A>T | p.Asn84Tyr | p.N84Y | P60903 | protein_coding | deleterious(0.02) | possibly_damaging(0.703) | TCGA-UF-A7JV-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
S100A10 | insertion | Frame_Shift_Ins | novel | c.265_266insGGTACATGTGTATAACGCGCAGGTTTGT | p.Val89GlyfsTer29 | p.V89Gfs*29 | P60903 | protein_coding | TCGA-CG-4440-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6281 | S100A10 | KINASE | GONADOTROPINS | 11356677 | ||
6281 | S100A10 | KINASE | DEXAMETHASONE | DEXAMETHASONE | 10358078 |
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